Malay students are an important part of economic and civilization development, lagging Malay students in Indonesia and Asia in general is a big spotlight. Regarding the readiness to face the world of work and the availability of employment opportunities for existing Malay students is still relatively low. This study uses a survey method with a population of Malay students in Riau Province with sampling in this study using proportional random sampling method and data collected by questionnaire and analyzed by quantitative analysis with multiple linear regression analysis. The results showed that the determinant factors that affect the entrepreneurial spirit of Malay students in Riau from four variables, namely self-factor, family factor, community environmental factor and proven learning method factor that self-factor (8,362> 2,000) and family factors (2,695> 2,000) significant influence. Whereas community environmental factors (0.089 <2,000) and learning methods (-0.122> -2,000) did not have a significant effect