This study aims to analyze the influence of the media on the opinion of millennials about vaccination, and to find out the results of that opinion. The method used is a quantitative method, carried out on 46 subject panelists in Pekanbaru, the respondents are millennials using simple random sampling technique. The results of the research found that there was an influence of social media on millennial opinions in Pekanbaru regarding vaccination, which meant here were 46 random respondents. This is why most of the respondents have not vaccinated. Respondents have fear because of positive and negative news circulating. Most of the messages that respondents get also come from privately owned social media.