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Repositori Institusi
Model percepatan penuntasan buta aksara (PPBA) melalui pelibatan guru berbasis zonasi
Masyarakat buta aksara masih menjadi salah satu permasalahan bangsa Indonesia dan senantiasa diperhatikan dan ditangani secara serius oleh pemerintah, masyarakat dan seluruh pemangku kebijakan, tetapi hingga saat ini masalah buta aksara tersebut be...
Jurnal Institusi
Synthesis, Reactivity and Stability of Aryl Halide Protecting Groups towards Di-Substituted Pyridines
Indonesian Journal of Chemistry; Vol 16, No 1 (2016); 53-58
This paper reports the synthesis and reactivity of different Benzyl derivative protecting groups. The synthesis and stability of Benzyl halides, 4-methoxybenzyl halides, 3,5-dimethoxybenzyl halides, 3,4-dimethoxybenzyl halides, 3,4,5-trimethoxybenzyl...
PubMed
Use of Multiplex Reverse Transcription-PCR To Study the Expression of a Laccase Gene Family in a Basidiomycetous Fungus
Appl Environ Microbiol
Laccases produced by white rot fungi are involved in the degradation of lignin and a broad diversity of other natural and synthetic molecules, having a great potential for biotechnological applications. They are frequently encoded by gene families, a...
PubMed
Total Synthesis of (S)-(+)-Tylophorine Via Enantioselective Intramolecular Alkene Carboamination
J Org Chem
[Image: see text] The enantioselective synthesis of (S)-(+)-tylophorine, a potent cancer cell growth inhibitor, has been accomplished in eight steps from commercially available 3,4-dimethoxybenzyl alcohol. A copper (II)-catalyzed enantioselective int...
PubMed
Novel Mechanism of N‐Solanesyl‐N,N′‐bis(3,4‐dimethoxybenzyl)ethylenediamine in Potentiation of Antitumor Drug Action on Multidrug‐resistant and Sensitive Chinese Hamster Cells
Jpn J Cancer Res
The mechanism of the synthetic isopremoid N‐solanesyl‐N,N′‐bis(3,4‐dimethoxybenzyl)ethylenediantine (SDB‐ethylenediamine) in potentiating antitumor drug action against multidrug‐resistant cells was comparatively studied with other poten...
PubMed
2-Imino-(3,4-dimethoxybenzyl) ethanesulfonic acid Schiff base anchored silver nanocomplex mediated by sugarcane juice and their antibacterial activities
Journal of Applied Research and Technology
In this present investigation, 2-imino-(3,4-dimethoxybenzyl)ethane sulphonic acid was anchored on a silver nanoparticle mediated by sugarcane sap. The Schiff base was synthesized from 2-aminoethanesulphonic acid and 3,4-dimethoxybenzaldehyde under le...
PubMed
Synergistic Effect in Culture of Bleomycin‐group Antibiotics and N‐Solanesyl‐N, N’‐bis(3,4‐dimethoxybenzyl)ethylenediamine, a Synthetic Isoprenoid
Jpn J Cancer Res
Like bleomycin and peplomycin, libromycin, a newly developed bleomycin‐group antibiotic, was potentiated 130‐fold against Chinese hamster V79 cells (V79/S) and 47‐fold against its multidrug‐resistant mutant (V79/ADM) by N‐solanesyl‐N, N...
PubMed
Lepidium graminifolium L.: Glucosinolate Profile and Antiproliferative Potential of Volatile Isolates
Molecules
Glucosinolates (GSLs) from Lepidium graminifolium L. were analyzed qualitatively and quantitatively by their desulfo-counterparts using UHPLC-DAD-MS/MS technique and by their volatile breakdown products-isothiocyanates (ITCs) using GC-MS analysis. Th...
PubMed
Highly Selective and Catalytic C–N Bond Cleavage of Tertiary Sulfonamides: Scope and Mechanistic Insight
ACS Omega
[Image: see text] A highly chemoselective C–N bond cleavage reaction of p-methoxybenzyl- (PMB), 3,4-dimethoxybenzyl- (DMB), or cinnamyl-substituted tertiary sulfonamides in the presence of catalytic Bi(OTf)(3) is presented. A wide range of sulfonam...
PubMed
The kinetics of hydrolysis of synthetic glucuronic esters and glucuronic ethers by bovine liver and Escherichia coli β-glucuronidase
Biochem J
1. The relative rates of hydrolysis of synthetically prepared β-d-glucuronic esters [aglycone: benzoic acid, veratroic (3,4-dimethoxybenzoic) acid, indol-3-ylacetic acid and ethylbutyric acid], and β-d-glucuronic ethers (aglycone: phenolphthalein, ...
PubMed
Pyrimidine Nucleosides Syntheses by Late-Stage Base Heterocyclization Reactions
Org Lett
[Image: see text] An efficient two-step procedure for the syntheses of pyrimidine nucleosides is presented. A series of glycosyl 5-(aminomethylene)-1,3-dioxane-4,6-dione derivatives were prepared from β-anomeric isonitriles by reaction with Meldrum...
PubMed
Bisphosphonium cation based metal halide glass scintillators with tunable melting points
Chem Sci
Organic–inorganic metal halide (OIMH) glass offers the advantages of large-scale production, high transparency, and minimal light scattering. However, undesired crystallization in OIMH glass can occur, leading to deteriorated transparency. Herein, ...
PubMed
Reversal of P‐Glycoprotein‐mediated Paclitaxel Resistance by New Synthetic Isoprenoids in Human Bladder Cancer Cell Line
Jpn J Cancer Res
We isolated a paclitaxel‐resistant cell line (KK47/TX30) from a human bladder cancer cell line (KK47/WT) in order to investigate the mechanism of and reversal agents for paclitaxel resistance. KK47/TX30 cells exhibited 700‐fold resistance to pacl...
PubMed
Synthesis and Biological Evaluation of 2,4-Diaminopyrimidine-Based Antifolate Drugs against Bacillus anthracis
Molecules
Due to the innate ability of bacteria to develop resistance to available antibiotics, there is a critical need to develop new agents to treat more resilient strains. As a continuation of our research in this area, we have synthesized a series of race...
PubMed
The effects of some phosphodiesterase inhibitors on the conductance of the perfused vascular beds of the chloralosed cat
Br J Pharmacol
1. The vasoactivity of a number of phosphodiesterase inhibitors in the auto-perfused splanchnic region and hindquarters of the cat have been investigated. 2. Theophylline, dipyridamole and 4-(3,4-dimethoxybenzyl)-2-imidazolidinone (Ro 7-2956) and its...
PubMed
Directed Evolution of a Halide Methyltransferase Enables Biocatalytic Synthesis of Diverse SAM Analogs
Angew Chem Int Ed Engl
Biocatalytic alkylations are important reactions to obtain chemo‐, regio‐ and stereoselectively alkylated compounds. This can be achieved using S‐adenosyl‐l‐methionine (SAM)‐dependent methyltransferases and SAM analogs. It was recently sh...
PubMed
Halide Abstraction-Mediated Synthesis of a Highly Twisted Amide
J Org Chem
[Image: see text] Highly strained [3.2.1] bicyclic twisted amide 2 and corresponding amidium 10 were synthesized for the first time through Ag(I)-mediated halide abstraction. After initial lactamization attempts failed, a second-generation strategy w...
PubMed
Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts
Cardiovasc Res
AIMS: Despite the lower patency of venous compared with arterial coronary artery bypass grafts, ∼50% of grafts used are saphenous vein conduits because of their easier accessibility. In a search for ways to increase venous graft patency, we applied...
PubMed
Regioselective Reactions of 3,4-Pyridynes Enabled by the Aryne Distortion Model
Nat Chem
The pyridine heterocycle continues to play a vital role in the development of human medicines. More than 100 currently-marketed drugs contain this privileged unit, which remains highly sought after synthetically. We report an efficient means to acces...
PubMed
Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis
Eur J Med Chem
A series of substituted 2,4-diaminopyrimidines 1 has been prepared and evaluated for activity against Bacillus anthracis using previously reported (±)-3-{5-[(2,4-diamino-5-pyrimidinyl)methyl]-2,3-dimethoxyphenyl}-1-(1-propyl-2(1H)-phthalazinyl)-2-pr...