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Repositori Institusi
10th International Conference on Malaysia-Indonesia Relations "Competition Law Enforcement in Indonesia and Malaysia: Cross-Border Challenges
This research analyses the challenge of anticompetitive cross-border conducts between Indonesia and Malaysia in the Perspectives of ASEAN Economic Community (AEC). The method uses in this study is normative and library-based study. When the AEC activ...
Jurnal Institusi
Pendidikan Kewirausahaan dan Digital Marketing dalam Menghadapi MEA Bagi Para Siswa di Perbatasan Negara
BIDIK: Jurnal Pengabdian kepada Masyarakat; Vol. 4 No. 1 (2023): Bidik: Jurnal Pengabdian kepada Masyarakat; 73-79
Since 2016, citizens in Indonesia have faced free competition within the framework of the AEC (ASEAN Economic Community). For this reason, the first step in facing the AEC is to introduce younger generation, especially at the state's borders, to...
PubMed
UTP regulation of ion transport in alveolar epithelial cells involves distinct mechanisms
Am J Physiol Lung Cell Mol Physiol
UTP is known to regulate alveolar fluid clearance. However, the relative contribution of alveolar type I cells and type II cells to this process is unknown. In this study, we investigated the effects of UTP on ion transport in type I-like cell (AEC I...
PubMed
Purinergic P2X(7) receptor regulates lung surfactant secretion in a paracrine manner
J Cell Sci
Alveolar epithelium is composed of alveolar epithelial cells of type I (AEC I) and type II (AEC II). AEC II secrete lung surfactant by means of exocytosis. P2X(7) receptor (P2X(7)R), a P2 purinergic receptor, has been implicated in the regulation of ...
PubMed
Primary Human Airway Epithelial Cell-Dependent Inhibition of Human Lung Mast Cell Degranulation
PLoS One
INTRODUCTION: Chronic mast cell activation is a characteristic feature of asthma. BEAS-2B human airway epithelial cells (AEC) profoundly inhibit both constitutive and IgE-dependent human lung mast cell (HLMC) histamine release. The aim of this study ...
PubMed
A selC-Associated Genomic Island of the Extraintestinal Avian Pathogenic Escherichia coli Strain BEN2908 Is Involved in Carbohydrate Uptake and Virulence
J Bacteriol
The complete nucleotide sequence and genetic organization of a new genomic island (AGI-3) isolated from the extraintestinal avian pathogenic Escherichia coli strain BEN2908 is reported. This 49,600-bp island is inserted at the selC locus and contains...
PubMed
Computed tomography assessment of anterior ethmoidal canal dehiscence: An interobserver agreement study and review of the literature
Neuroradiol J
PURPOSE: The anterior ethmoidal artery can be injured in functional endoscopic sinus surgery. The ability of computed tomography (CT) to identify dehiscence of the anterior ethmoidal canal (AEC) has not been widely evaluated. The aim of this study wa...
PubMed
Differential PERP Regulation by TP63 Mutants Provides Insight into AEC Pathogenesis
Am J Med Genet A
Ankyloblepharon Ectodermal Dysplasia and Cleft Lip/Palate (AEC) or Hay-Wells Syndrome is an autosomal dominant disorder characterized by a variety of phenotypes in ectodermal derivatives, including severe skin erosions, ankyloblepharon, coarse and wi...
PubMed
A Novel Model System to Identify Cellular and Molecular Defects Underlying Rare Genetic Disorders
Exp Dermatol
Ankyloblepharon‐ectodermal defects‐cleft lip/palate (AEC) is a disorder caused by autosomal‐dominant mutations in the TP63 gene. AEC is characterised by the presence of severe and painful skin erosions that can take years to heal. Current treat...
PubMed
Genomic Profiling of a Human Organotypic Model of AEC Syndrome Reveals ZNF750 as an Essential Downstream Target of Mutant TP63
Am J Hum Genet
The basis for impaired differentiation in TP63 mutant ankyloblepharon-ectodermal dysplasia-clefting (AEC) syndrome is unknown. Human epidermis harboring AEC TP63 mutants recapitulated this impairment, along with downregulation of differentiation acti...
PubMed
ΔNp63 Knockdown Mice: A Mouse Model for AEC Syndrome
Am J Med Genet A
Dominant mutations in TP63 cause ankyloblepharon ectodermal dysplasia and clefting (AEC), an ectodermal dysplasia characterized by skin fragility. Since ΔNp63α is the predominantly expressed TP63 isoform in postnatal skin, we hypothesized that muta...
PubMed
A Prospective Audit Investigating How the Anticholinergic Effect of Medications on Cognition Is Assessed and Reduced in Patients Admitted to an Older Adult Ward in a Psychiatric Hospital
BJPsych Open
Aims: Older adults often have multiple comorbidities associated with an increased risk of anticholinergic effects. Mental health medications increase this risk, contributing to cognitive decline, dementia, memory loss and confusion. Evidence suggests...
PubMed
The Corynebacterium glutamicum aecD gene encodes a C-S lyase with alpha, beta-elimination activity that degrades aminoethylcysteine.
J Bacteriol
S-(beta-Aminoethyl)-cysteine (AEC) resistance was achieved in Corynebacterium glutamicum by cloning a chromosomal 1.5-kb EcoRV-BglII DNA fragment on a multicopy plasmid. DNA sequence analysis of the 1.5-kb DNA fragment revealed an open reading frame ...
PubMed
Tooth defects of EEC and AEC syndrome caused by heterozygous TP63 mutations in three Chinese families and genotype‐phenotype correlation analyses of TP63‐related disorders
Mol Genet Genomic Med
BACKGROUND: Ectrodactyly‐Ectodermal dysplasia‐Cleft lip/palate (EEC) syndrome and Ankyloblepharon‐Ectodermal defects‐Cleft lip/palate (AEC) syndrome belong to p63 syndromes, a group of rare disorders exhibiting a wide variety of clinical mani...
PubMed
Arterial endothelial cytokines guide extravillous trophoblast invasion towards spiral arteries; an in-vitro study with the trophoblast cell line ACH-3P and female non-uterine endothelial cells
Placenta
INTRODUCTION: Invasion of extravillous trophoblasts (EVT) is tightly linked to appropriate cell to cell contact as well as paracrine guidance of EVT by maternal uterine cells, conducted by a variety of locally expressed cytokines. Here we investigate...
PubMed
Mechanisms of suppression of alveolar epithelial cell GM-CSF expression in the setting of hyperoxic stress
Am J Physiol Lung Cell Mol Physiol
Pulmonary expression of granulocyte/macrophage colony-stimulating factor (GM-CSF) is critically important for normal functional maturation of alveolar macrophages. We found previously that lung GM-CSF is dramatically suppressed in mice exposed to hyp...
PubMed
Chemokine expression in the early response to injury in human airway epithelial cells
PLoS One
Basal airway epithelial cells (AEC) constitute stem/progenitor cells within the central airways and respond to mucosal injury in an ordered sequence of spreading, migration, proliferation, and differentiation to needed cell types. However, dynamic ge...
PubMed
Extrinsic Calcitonin Gene-Related Peptide Inhibits Hyperoxia-Induced Alveolar Epithelial Type II Cells Apoptosis, Oxidative Stress, and Reactive Oxygen Species (ROS) Production by Enhancing Notch 1 and Homocysteine-Induced Endoplasmic Reticulum Protein (HERP) Expression
Med Sci Monit
BACKGROUND: Lung alveolar epithelial type II cells (AEC II) are the most important stem cells in lung tissues, which are critical for wound repair of bronchopulmonary dysplasia (BPD). This study investigated the effects of calcitonin gene-related pep...
PubMed
miR-375 regulates rat alveolar epithelial cell trans-differentiation by inhibiting Wnt/β-catenin pathway
Nucleic Acids Res
Alveolar epithelial cell (AEC) trans-differentiation is a process where type II alveolar epithelial cells (AEC II) trans-differentiate into type I alveolar epithelial cells (AEC I) during lung recovery after various injuries, in which AEC I are damag...
PubMed
The relationship between microbial community vitality and ATP bioburden in bottom waters under fuel microcosms
Access Microbiol
Adenylate energy charge (AEC) – computed from the ATP, ADP and AMP concentrations in a specimen – reflect the net physiological state of the microbial population in that specimen. Previous research has demonstrated that healthy microbial populati...