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Essential role for ALCAM gene silencing in megakaryocytic differentiation of K562 cells
BMC Mol Biol
BACKGROUND: Activated leukocyte cell adhesion molecule (ALCAM/CD166) is expressed by hematopoietic stem cells. However, its role in hematopoietic differentiation has not previously been defined. RESULTS: In this study, we show that ALCAM expression i...
PubMed
Analysis and Multilabel Classification of Quebec Court Decisions in the Domain of Housing Law
Natural Language Processing and Information Systems
The Régie du Logement du Québec (RDL) is a tribunal with exclusive jurisdiction in matters regarding rental leases. Within the framework of the ACT (Autonomy Through Cyberjustice Technologies) project, we processed an original collection of court d...
PubMed
The beauty of the beast: Suggestions to curb the excesses of dog breeding and restore animal welfare – Invited review
Vet Med (Praha)
Dog. Specifically created to save its master’s life. – (The dog is the ideal) Friend of man, (because it is his devoted slave) (source: Gustave Flaubert, Dictionnaire des Idées Reçues). But is man the best friend of the dog? This question is le...
PubMed
Cancer and the tumor microenvironment: a review of an essential relationship
Cancer Chemother Pharmacol
PURPOSE: The role of the microenvironment during the initiation and progression of carcinogenesis is now realized to be of critical importance, both for enhanced understanding of fundamental cancer biology, as well as exploiting this source of relati...
PubMed
Cloning of the human activated leukocyte cell adhesion molecule promoter and identification of its tissue-independent transcriptional activation by Sp1
Cell Mol Biol Lett
Activated leukocyte cell adhesion molecule (ALCAM) belongs to the immunoglobulin cell adhesion molecule super family. ALCAM is implicated in tumor progression, inflammation, and the differentiation of hematopoietic stem cells. Hitherto, the identity ...
PubMed
Water Quality and Anopheles gambiae Larval Tolerance to Pyrethroids in the Cities of Douala and Yaoundé (Cameroon)
J Trop Med
The poor management of the urban environment in sub-Saharan Africa is affecting Anopheles gambiae susceptibility to insecticides. A study was undertaken to assess the influence of breeding sites physicochemical parameters on malaria vectors populatio...
PubMed
Dietary deficiency increases presenilin expression, gamma-secretase activity and Abeta levels: potentiation by ApoE genotype and alleviation by S-adenosyl methionine
J Neurochem
Apolipoprotein E4 (ApoE4) is a risk factor for Alzheimer's disease (AD). Whether this risk arises from a deficient function of E4 or the lack of protection provided by E2 ir E3 is unclear. Previous studies demonstrate that deprivation of folate ...
PubMed
The usefulness of NLP techniques for predicting peaks in firefighter interventions due to rare events
Neural Comput Appl
In some countries such as France, the number of operations assisted by firefighters has shown an almost linear increase over the years, contrary to their resource capacity. For this reason, predicting the number of interventions has become a necessit...
PubMed
Acute Changes in Rat Tissue Gene Expression Following Exposure to Flight Relevant Hypobaria
Sci Data
Aeromedical evacuation (AE) is an invaluable tool for the transport of critically injured patients to care facilities. There is increasing evidence obtained from animal models and human patients that exposure to AE-relevant hypobaria within a few day...
PubMed
Hypobaria-Induced Oxidative Stress Facilitates Homocysteine Transsulfuration and Promotes Glutathione Oxidation in Rats with Mild Traumatic Brain Injury
J Cent Nerv Syst Dis
BACKGROUND: United States service members injured in combat theatre are often aeromedically evacuated within a few days to regional military hospitals. Animal and epidemiological research indicates that early exposure to flight hypobaria may worsen b...
PubMed
Preemptive endoluminal vacuum therapy after pancreaticoduodenectomy: A case report
World J Gastrointest Endosc
BACKGROUND: Pancreaticoduodenectomy is a technically demanding operation, with reported morbidity rates of approximately 40%–50%. A novel idea is to use endoscopic vacuum therapy (EVT) in a preemptive setting to prevent anastomotic leakage and panc...
PubMed
Dynamics of Antibodies to Ebolaviruses in an Eidolon helvum Bat Colony in Cameroon
Viruses
The ecology of ebolaviruses is still poorly understood and the role of bats in outbreaks needs to be further clarified. Straw-colored fruit bats (Eidolon helvum) are the most common fruit bats in Africa and antibodies to ebolaviruses have been docume...
PubMed
Hyperhomocysteinemia-Induced Oxidative Stress Exacerbates Cortical Traumatic Brain Injury Outcomes in Rats
Cell Mol Neurobiol
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality among military service members and civilians in the United States. Despite significant advances in the understanding of TBI pathophysiology, several clinical reports indicate ...
PubMed
Urban Green Spaces and Vector-Borne Disease Risk in Africa: The Case of an Unclean Forested Park in Libreville (Gabon, Central Africa)
Int J Environ Res Public Health
In Africa, vector-borne diseases are a major public health issue, especially in cities. Urban greening is increasingly considered to promote inhabitants’ well-being. However, the impact of urban green spaces on vector risk remains poorly investigat...
PubMed
Standardized Bioassays to Better Understand the Invasion Dynamics of the Global Arbovirus Vector Aedes albopictus
Curr Protoc
The global spread of the arbovirus vector Aedes albopictus has become a major public health concern. In tropical regions, competitive interactions with native species such as Aedes aegypti may have influenced its invasive success. Understanding the b...
PubMed
Rat Model of Brain Injury to Occupants of Vehicles Targeted by Land Mines: Mitigation by Elastomeric Frame Designs
J Neurotrauma
Many victims of blast traumatic brain injury (TBI) are occupants of vehicles targeted by land mines. A rat model of under-vehicle blast TBI was used to test the hypothesis that the ensuing neuropathology and altered behavior are mitigated by vehicle ...
PubMed
The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury
Neuropharmacology
Traumatic brain injury (TBI) is the leading cause of death in young adults in the United States, but there is still no effective agent for treatment. N-arachidonoylethanolamine (anandamide, AEA) is a major endocannabinoid in the brain. Its increase a...