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DOAJ Open Access
Metabolic engineering of endogenous MEP pathway for enhanced lycopene production in Escherichia coli
Synthetic and Systems Biotechnology, Vol 13, Iss , Pp 109-119 (2026) | ISSN: 2405-805X
Microbial cell factories represent the primary approach for heterologous lycopene synthesis, where gene source selection and pathway regulation have been demonstrated to have a significant impact on lycopene titer. In this study, key lycopene biosynt...
Repositori Institusi
Perbandingan Metode Naïve Bayes Dan K-Nearest Neighbor Dalam Klasifikasi Penyakit ISPA (Studi kasus : Klinik Kiki)
Thesis
Infeksi Saluran Pernapasan Akut (ISPA) atau yang kita sering sebut ISPA merupakan penyakit yang umum terjadi pada semua kategori umur, terutama pada anak-anak. Tingkat keparahan penyakit ISPA bervariasi dari faringitas ringan sampai
berat bahkan sa...
Repositori Institusi
Klasifikasi Penyakit Infeksi Saluran Pernapasan Menggunakan Algoritma Naïve Bayes
Thesis
Kemajuan peradaban manusia telah semakin berkembang pesat di segala bidang kehidupan. Ilmu pengetahuan dan teknologi ini menjadi bagian yg tidak terpisahkan dari kehidupan masyarakat modern. Tidak bisa dipungkiri bahwa akibat modernisasi melahirkan i...
Jurnal Institusi
Aplikasi sistem pakar diagnosis penyakit ispa berbasis speech recognition menggunakan metode naive bayes classifier
Digital Zone: Jurnal Teknologi Informasi dan Komunikasi; Vol. 8 No. 1 (2017): Digital Zone: Jurnal Teknologi Informasi dan Komunikasi; 58-70
Abstrak- ISPA (Infeksi Saluran Pernafasan Akut) adalah suatu penyakit gangguan saluran pernapasan yang dapat menimbulkan berbagai spektrum penyakit mulai dari penyakit tanpa gejala, infeksi ringan sampai penyakit yang parah dan mematikan akibat fakto...
Jurnal Institusi
Analisa Komplikasi Penyakit Infeksi Dan Riwayat Berat-Panjang Badan Saat Lahir Pada Kejadian Stunting Balita Di Indonesia
Jurnal Niara; Vol. 16 No. 1 (2023): Mei; 149-166
Stunting merupakan salah satu gangguan pertumbuhan kronis yang berkaitan dengan pertumbuhan Tinggi badan berdasarkan umur. Faktor penyebab stunting secara langsung adalah gangguan nutrisi, disertai dengan penyakit infeksi, dan riwayat kondi...
PubMed
A redundant isoprenoid biosynthetic pathway supports Staphylococcus aureus metabolic versatility
mBio
Isoprenoids are ubiquitous molecules that serve as fundamental building blocks for life. In bacteria, isoprenoids are precursors for carotenoid pigments, respiratory cofactors, and essential sugar carrier lipids, such as lipid II. Isoprenoid synthesi...
PubMed
Control of myeloid-derived suppressor cell dynamics potentiates vaccine protection in multiple mouse models of Trypanosoma cruzi infection
Front Immunol
To date, there is no licensed vaccine against the protozoan parasite Trypanosoma cruzi (T. cruzi), the etiological agent of Chagas Disease. T. cruzi has evolved numerous mechanisms to evade and manipulate the host immune system. Among the subversive ...
PubMed
Mutation to ispA Produces Stable Small-Colony Variants of Pseudomonas aeruginosa That Have Enhanced Aminoglycoside Resistance
Antimicrob Agents Chemother
Pseudomonas aeruginosa is a major pathogen in burn wound infections. We present one of the first reports of small-colony variant (SCV) emergence of P. aeruginosa, taken from a patient under aminoglycosides for a persistent burn wound infection. We co...
PubMed
An Improved Mathematical Scheme for LTE-Advanced Coexistence with FM Broadcasting Service
PLoS One
Power spectral density (PSD) overlapping analysis is considered the surest approach to evaluate feasibility of compatibility between wireless communication systems. In this paper, a new closed-form for the Interference Signal Power Attenuation (ISPA)...
PubMed
A New Cage-Like Particle Adjuvant Enhances Protection of Foot-and-Mouth Disease Vaccine
Front Vet Sci
Foot-and-Mouth Disease (FMD) is an acute viral disease that causes important economy losses. Vaccines with new low-cost adjuvants that stimulate protective immune responses are needed and can be assayed in a mouse model to predict their effectiveness...
PubMed
Fabrication and Encapsulation of Soy Peptide Nanoparticles Using Ultrasound Followed by Spray Drying
Foods
Peptide aggregation inevitably occurs during hydrolysis, and insoluble peptide aggregates (ISPA) are used as feed for animals due to their poor water solubility and unpleasant bitter flavor. Ultrasound was used to fabricate soy peptide nanoparticles ...
PubMed
Protein solution structure determination using distances from two-dimensional nuclear Overhauser effect experiments: effect of approximations on the accuracy of derived structures.
Proc Natl Acad Sci U S A
Solution structures for many proteins have been determined to date utilizing interproton distance constraints estimated from two-dimensional nuclear Overhauser effect (2D NOE) spectra. Although the simple isolated spin pair approximation (ISPA) gener...
PubMed
Targeting Myeloid-Derived Suppressor Cells to Enhance a Trans-Sialidase-Based Vaccine Against Trypanosoma cruzi
Front Cell Infect Microbiol
Trypanosoma cruzi (T. cruzi) is a hemoflagellate protozoan parasite that causes Chagas disease, a neglected tropical disease that affects more than 6 million people around the world, mostly in Latin America. Despite intensive research, there is no va...
PubMed
The ISPA(Int) Injury Prevention Programme for Youth Competitive Alpine Skiers: A Controlled 12-Month Experimental Study in a Real-World Training Setting
Front Physiol
Evidence-based injury prevention programmes for youth competitive alpine skiers are widely absent. The aims of this controlled 12-month experimental study were to introduce a novel injury prevention programme targeted to the injury patterns of youth ...
PubMed
The disruption of prenylation leads to pleiotropic rearrangements in cellular behavior in Staphylococcus aureus
Mol Microbiol
Prenylation is the addition of prenyl groups to peptide chains or metabolites via the condensation of geranyl- or isopentenyl-diphosphate moieties by geranyltranstransferases. Although this process is extensively studied in eukaryotes, little is know...
PubMed
Isolation and characterization of an Escherichia coli mutant having temperature-sensitive farnesyl diphosphate synthase.
J Bacteriol
The screening of a collection of highly mutagenized strains of Escherichia coli for defects in isoprenoid synthesis led to the isolation of a mutant that had temperature-sensitive farnesyl diphosphate synthase. The defective gene, named ispA, was map...
PubMed
Induction of Sustained Immunity Following Vaccination with Live Attenuated Trypanosoma cruzi Parasites Combined with Saponin-Based Adjuvants
Biology (Basel)
Chagas disease, caused by Trypanosoma cruzi, remains a major health concern in Latin America, particularly affecting low-income and rural communities. Among the many vaccine strategies explored, live attenuated parasites have shown the strongest abil...
PubMed
Statistical Experimental Design Guided Optimization of a One-Pot Biphasic Multienzyme Total Synthesis of Amorpha-4,11-diene
PLoS One
In vitro synthesis of chemicals and pharmaceuticals using enzymes is of considerable interest as these biocatalysts facilitate a wide variety of reactions under mild conditions with excellent regio-, chemo- and stereoselectivities. A significant chal...
PubMed
Imipenem-Resistant Pseudomonas aeruginosa: Risk Factors for Nosocomial Infections
J Korean Med Sci
The aim of this study was to determine the risk factors for nosocomial infections of imipenem-resistant Pseudomonas aeruginosa (IRPA). A prospective case-control study was performed at a tertiary care hospital in Ankara from January to December 2004....
PubMed
Inhibition of Coenzyme Qs Accumulation in Engineered Escherichia coli by High Concentration of Farnesyl Diphosphate
Avicenna J Med Biotechnol
BACKGROUND: Coenzyme Q ( 10 ) (CoQ ( 10 ) ) is an isoprenoid component used widely in nutraceutical industries. Farnesyl diphosphate synthase (FPPS) is a responsible enzyme for biosynthesis of farnesyl diphosphate (FPP), a key precursor for CoQs prod...