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Basosquamous Basal Cell Carcinoma with Bone Marrow Metastasis
Curr Oncol
Basal cell carcinoma (BCC) is the most common cancer in Caucasians. It is slow growing and rarely metastasizes. If left untreated over time, invasive growth can occur. We present a patient case with a primary BCC located in the right sub-mammary area...
PubMed
Prognostic value of uPAR expression and angiogenesis in primary and metastatic melanoma
PLoS One
Angiogenesis is important for the progression of cutaneous melanoma. Here, we analyzed the prognostic impact of the angiogenic factor urokinase plasminogen activator resecptor (uPAR), vascular proliferation index (VPI) and tumor necrosis as a measure...
PubMed
Subcellular Phenotyping: Using Proteomics to Quantitatively Link Subcellular Leaf Protein and Organelle Distribution Analyses of Pisum sativum Cultivars
Front Plant Sci
Plant phenotyping to date typically comprises morphological and physiological profiling in a high-throughput manner. A powerful method that allows for subcellular characterization of organelle stoichiometric/functional characteristics is still missin...
PubMed
Expression of β-Catenin, E-Cadherin, and α-Smooth Muscle Actin in Basal Cell Carcinoma Before Photodynamic Therapy in Non-recurrent and Recurrent Tumors: Exploring the Ability of Predicting Photodynamic Therapy Outcome
J Histochem Cytochem
Photodynamic therapy (PDT) is an effective and cosmetically beneficial treatment of low-risk basal cell carcinomas (BCCs). To optimize PDT response, it is important to correctly select tumors. We sought to find markers that could identify such tumors...
PubMed
Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma
BMC Cancer
BACKGROUND: Tumor cell proliferation is a predictor of survival in cutaneous melanoma. The aim of the present study was to evaluate the prognostic impact of mitotic count, Ki-67 expression and novel proliferation markers phosphohistone H3 (PHH3), min...
PubMed
PubMed
Tumor necrosis is associated with increased alpha(v)beta(3 )integrin expression and poor prognosis in nodular cutaneous melanomas
BMC Cancer
BACKGROUND: Tumor necrosis and apoptotic activity are considered important in cancer progression, but these features have not been much studied in melanomas. Our hypothesis was that rapid growth in cutaneous melanomas of the vertical growth phase mig...
PubMed
Two New Cases of Bachmann–Bupp Syndrome Identified through the International Center for Polyamine Disorders
Med Sci (Basel)
Recent identification of four additional polyaminopathies, including Bachmann–Bupp syndrome, have benefited from previous research on Snyder–Robinson syndrome in order to advance from research to treatment more quickly. As a result of the discove...
PubMed
Successful Zero-Fluoroscopy Ablation of an Atypical Clockwise Simple-Loop Biatrial Flutter Involving the Bachmann Bundle Region
JACC Case Rep
A 69-year-old woman presented with an atypical clockwise simple-loop biatrial flutter as a consequence of an anterior mitral line ablation for perimitral atrial flutter. Local activation mapping and entrainment maneuvers helped define the circuit, hi...
PubMed
Dr. Vivian Pinn: a woman pioneer & leader
Womens Midlife Health
The Women’s Health Institute in collaboration with the Journal of Women’s Midlife Health hosted a national roundtable with Dr. Vivian Pinn via Zoom to honor her for her achievements in the areas of women’s health, wellness, and research. The pa...
PubMed
Evaluation of Bachmann Bundle Pacing Versus Right Atrial Pacing in Prevention of Atrial Fibrillation After Coronary Artery Bypass Surgery
Indian Pacing Electrophysiol J
BACKGROUND: In patients undergoing coronary artery bypass surgery (CABGS), occurrence of atrial fibrillation (AF) is common in the postoperative period and is associated with increased morbidity with longer intensive unit care (ICU) and hospital stay...
PubMed
Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer
Proc Natl Acad Sci U S A
The mechanisms underlying tumor dormancy have been elusive and not well characterized. We recently published an experimental model for the study of human tumor dormancy and the role of angiogenesis, and reported that the angiogenic switch was precede...
PubMed
Melanoma prone families with CDK4 germline mutation: phenotypic profile and associations with MC1R variants
J Med Genet
BACKGROUND: CDKN2A and CDK4 are high risk susceptibility genes for cutaneous malignant melanoma. Melanoma families with CDKN2A germline mutations have been extensively characterised, whereas CDK4 families are rare and lack a systematic investigation ...
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