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# Judul Penulis Tahun Akses
Jurnal Institusi

Two Isophalerin Compounds from Ethyl Acetate of Leave and Fruit of Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.) and Its Antibacterial Activity

Indonesian Journal of Chemistry; Vol 15, No 2 (2015); 179-186
Universitas Gadjah Mada, 2015DOI: 10.22146/ijc.21212http://creativecommons.org/licenses/by-nc-nd/4.0
Mahkota dewa plant (Phaleria macrocarpa (Scheff.) Boerl.) which is belong to family of Thymelaeaceae is one of Indonesia's traditional medicines. The aim of this research is to isolate secondary metabolites from ethyl acetate extract of leave an...
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PubMed

Protective Effect of Phaleria macrocarpa Water Extract (Proliverenol) against Carbon Tetrachloride-Induced Liver Fibrosis in Rats: Role of TNF-α and TGF-β1

J Toxicol
Wiley, 2018DOI: 10.1155/2018/2642714https://creativecommons.org/licenses/by/4.0/
Phaleria macrocarpa is one of the Indonesian herbal plants which has been shown to have a hepatoprotective effect. This study was conducted to evaluate the protective effect of water extract of mahkota dewa (Phaleria macrocarpa) in liver fibrosis and...
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PubMed

Phytochemistry and medicinal properties of Phaleria macrocarpa (Scheff.) Boerl. extracts

Pharmacogn Rev
Wolters Kluwer -- Medknow Publications, 2013DOI: 10.4103/0973-7847.112853https://creativecommons.org/licenses/by-nc-sa/3.0/
Phaleria macrocarpa, commonly known as Mahkota dewa is a medicinal plant that is indigenous to Indonesia and Malaysia. Extracts of P. macrocarpa have been used since years in traditional medicine that are evaluated scientifically as well. The extract...
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PubMed

Comparative Study of Antiproliferative Activity in Different Plant Parts of Phaleria macrocarpa and the Underlying Mechanism of Action

ScientificWorldJournal
Wiley, 2022DOI: 10.1155/2022/3992660https://creativecommons.org/licenses/by/4.0/
Phaleria macrocarpa is a medicinal plant widely used in Indonesian folk medicine to treat several diseases, including cancer. However, the comparative evaluation of various plant parts of P. macrocarpa has not been studied for their anticancer proper...
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PubMed

Antioxidant Activities and Tyrosinase Inhibition Effects of Phaleria Macrocarpa Extracts

Afr J Tradit Complement Altern Med
African Traditional Herbal Medicine Supporters Initiative, 2014DOI: 10.4314/ajtcam.v11i3.16Copyright © Afr. J. Traditional Complementary and Alternative Medicines 2014
BACKGROUND: The ethyl acetate and chloroform extracts of stems, leaves and fruits of Phaleria macrocarpa were screened for their antioxidant capacity and tyrosinase inhibition properties. MATERIAL AND METHOD: The total phenolic content (TPC), 1,1-dip...
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PubMed

Antioxidant, Anti-inflammatory and Cytotoxicity of Phaleria macrocarpa (Boerl.) Scheff Fruit

BMC Complement Altern Med
BMC, 2011DOI: 10.1186/1472-6882-11-110https://creativecommons.org/licenses/by/2.0/
BACKGROUND: Phaleria macrocarpa (Scheff.) Boerl (Thymelaceae) originates from Papua Island, Indonesia and grows in tropical areas. The different parts of the fruit of P. macrocarpa were evaluated for antioxidant, anti-inflammatory, and cytotoxic acti...
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PubMed

Phytochemical characteristics from Phaleria macrocarpa and its inhibitory activity on the peritoneal damage of endometriosis

J Ayurveda Integr Med
Elsevier, 2020DOI: 10.1016/j.jaim.2020.06.002https://creativecommons.org/licenses/by-nc-nd/4.0/
BACKGROUND: Endometriois represents a gynecological disease that still becomes an issue in community. Phaleria macrocarpa is a plant native to Indonesia that contains an antioxidant substance, which may serve as apoptotic modulator and useful for ang...
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PubMed

Effect of Phaleria macrocarpa on sexual function of rats

Avicenna J Phytomed
Mashhad University of Medical Sciences, 2013http://creativecommons.org/licenses/by/3.0/
Objectives: The purpose of current study was to determine the effect of Phaleria macrocarpa (P. macrocarpa) fruits aqueous extract on reproductive performance of adult male rats by assessing the serum testosterone level and evaluating their libido be...
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PubMed

Effect of Phaleria Macrocarpa (Scheff.) Boerl Leaf Ethanol Extract on Serum IL-6 and TNF-α Levels in Diabetic Rats

Med Arch
The Academy of Medical Sciences of Bosnia and Herzegovina, 2023DOI: 10.5455/medarh.2023.77.254-257https://creativecommons.org/licenses/by-nc/4.0/
BACKGROUND: Hyperglycemia conditions in diabetes mellitus (DM) can turn on pro-inflammatory cytokines like IL-6 and TNF-α. These cytokines play a role in insulin resistance and the development of DM complications. People in Indonesia have used Phale...
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PubMed

Flavonoid Analyses and Antimicrobial Activity of Various Parts of Phaleria macrocarpa (Scheff.) Boerl Fruit

Int J Mol Sci
Multidisciplinary Digital Publishing Institute (MDPI), 2011DOI: 10.3390/ijms12063422http://creativecommons.org/licenses/by/3.0/
Phaleria macrocarpa (Scheff.) Boerl (Thymelaceae) is commonly known as ‘Crown of God’, ‘Mahkota Dewa’, and ‘Pau’. It originates from Papua Island, Indonesia and it grows in tropical areas. Empirically, it is potent in treating the hyperte...
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PubMed

Phaleria macrocarpa (Scheff.) Boerl.: An updated review of pharmacological effects, toxicity studies, and separation techniques

Saudi Pharm J
Springer, 2023DOI: 10.1016/j.jsps.2023.04.006https://creativecommons.org/licenses/by-nc-nd/4.0/
Phaleria macrocarpa (Scheff.) Boerl. is geographically distributed around Papua Island, Indonesia. Traditionally, P. macrocarpa is exercised to reduce pain, stomachache, diarrhea, tumor problems, blood glucose, cholesterol, and blood pressure. A grow...
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PubMed

Antioxidants, Phytochemicals, and Cytotoxicity Studies on Phaleria macrocarpa (Scheff.) Boerl Seeds

Biomed Res Int
Wiley, 2014DOI: 10.1155/2014/410184https://creativecommons.org/licenses/by/3.0/
In recent years, the utilization of certain medicinal plants as therapeutic agents has drastically increased. Phaleria macrocarpa (Scheff.) Boerl is frequently used in traditional medicine. The present investigation was undertaken with the purpose of...
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PubMed

Effect of Phaleria Macrocarpa Flesh Fruits Extract on MDA Level, SGOT and SGPT Activity in Serum of Experimental Rats Contaminated by Cd (II) Ion

Open Access Maced J Med Sci
Scientific Foundation SPIROSKI, 2019DOI: 10.3889/oamjms.2019.786http://creativecommons.org/licenses/CC BY-NC/4.0
BACKGROUND: Cd (II) ion is a heavy metal that has a toxic ability in the human body. P. macrocarpa has been used as anticancer, Diabetes Mellitus and antimicrobe because it consists of flavonoid, steroid, and tannin. AIM: The purpose of this study wa...
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PubMed

Effect of Temperatures on Drying Kinetics, Extraction Yield, Phenolics, Flavonoids, and Antioxidant Activity of Phaleria macrocarpa (Scheff.) Boerl. (Mahkota Dewa) Fruits

Foods
Multidisciplinary Digital Publishing Institute (MDPI), 2023DOI: 10.3390/foods12152859https://creativecommons.org/licenses/by/4.0/
Phaleria macrocarpa (Scheff.) Boerl. or ‘Mahkota Dewa’ is a popular plant found in Malaysia as it is a valuable source of phytochemicals and therapeutic properties. Drying is an essential step in the storage of P. macrocarpa fruits at an industri...
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PubMed

Phaleria macrocarpa Boerl. (Thymelaeaceae) Leaves Increase SR-BI Expression and Reduce Cholesterol Levels in Rats Fed a High Cholesterol Diet

Molecules
Multidisciplinary Digital Publishing Institute (MDPI), 2015DOI: 10.3390/molecules20034410http://creativecommons.org/licenses/by/4.0/
In vitro and in vivo studies of the activity of Phaleria macrocarpa Boerl (Thymelaeaceae) leaves against the therapeutic target for hypercholesterolemia were done using the HDL receptor (SR-BI) and hypercholesterolemia-induced Sprague Dawley rats. Th...
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PubMed

Wound-healing potential of the fruit extract of Phaleria macrocarpa

Bosn J Basic Med Sci
Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina, 2015DOI: 10.17305/bjbms.2015.39Copyright: © 2015 ABMSFBIH
The wound-healing potential of Phaleria macrocarpa was evaluated by monitoring the levels of inflammatory mediators, collagen, and antioxidant enzymes. Experimentally, two-centimeter-wide full-thickness-deep skin excision wounds were created on the p...
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PubMed

Rapid investigation of α-glucosidase inhibitory activity of Phaleria macrocarpa extracts using FTIR-ATR based fingerprinting

J Food Drug Anal
Food and Drug Administration, Taiwan, 2016DOI: 10.1016/j.jfda.2016.09.007https://creativecommons.org/licenses/by-nc-nd/4.0/
Phaleria macrocarpa, known as “Mahkota Dewa”, is a widely used medicinal plant in Malaysia. This study focused on the characterization of α-glucosidase inhibitory activity of P. macrocarpa extracts using Fourier transform infrared spectroscopy (...
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PubMed

Testicular morphology of male rats exposed to Phaleria macrocarpa (Mahkota dewa) aqueous extract

Iran J Basic Med Sci
Mashhad University of Medical Sciences, 2014https://creativecommons.org/licenses/by-nc-sa/3.0/
OBJECTIVE(S): This study was designed to investigate the effect of Phaleria macrocarpa aqueous extract (PM) on spermatogenesis by observing the histological changes of testes in adult male rats. MATERIALS AND METHODS: PM was prepared by boiling the d...
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PubMed

Development of Phaleria macrocarpa (Scheff.) Boerl Fruits Using Response Surface Methodology Focused on Phenolics, Flavonoids and Antioxidant Properties

Molecules
Multidisciplinary Digital Publishing Institute (MDPI), 2018DOI: 10.3390/molecules23040724http://creativecommons.org/licenses/by/4.0/
In this study, the optimal conditions for the extraction of antioxidants from the Buah Mahkota Dewa fruit (Phaleria macrocarpa) was determined by using Response Surface Methodology (RSM). The optimisation was applied using a Central Composite Design ...
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PubMed

Two-Step Non-Food Valorization of Phaleria macrocarpa Fruit Lignin into Lignin Nanoparticles and Quantum Dots for Antibacterial and Bioimaging Applications

Int J Mol Sci
Multidisciplinary Digital Publishing Institute (MDPI), 2026DOI: 10.3390/ijms27041945https://creativecommons.org/licenses/by/4.0/
Lignin from Phaleria macrocarpa (Mahkota Dewa) fruit, a bioactive-rich cultivated medicinal biomass, was employed as a renewable precursor for lignin quantum dots (LQDs). A simple, aqueous, catalyst-free two-step route (lignin to lignin nanoparticles...
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