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DOAJ Open Access
Enzyme promiscuity-driven co-production of flavonoid 7-O-glycosides in engineered Saccharomyces cerevisiae
Synthetic and Systems Biotechnology, Vol 13, Iss , Pp 251-260 (2026) | ISSN: 2405-805X
Flavonoid 7-O-glycosides are a key class of bioactive flavonoid derivatives with broad application prospects in functional foods and nutraceuticals. Currently, their production is mainly dependent on unsustainable plant extraction or inefficient chem...
Jurnal Institusi
Penyuluhan Bahaya Narkoba, Gadget, dan Pergaulan Bebas Untuk Siswa SMA Negeri 1 Lhoknga
Dinamisia : Jurnal Pengabdian Kepada Masyarakat; Vol. 5 No. 4 (2021): Dinamisia: Jurnal Pengabdian Kepada Masyarakat
Persuasive counseling can prevent drug use in students. Through counseling, students are expected to understand the dangers of drugs, gadgets, and promiscuity. The community service aims to provide counseling concerning the dangers of drugs, gadgets,...
Jurnal Institusi
Tindak Pidana Pemerkosaan Dengan Kekerasan Yang Dilakukan Secara Bersama-Sama Ditinjau Dari Perspektif Psikologi Kriminal (Studi Putusan Nomor Xx/Pid.B/2022/Pn.Tlk)
Jurnal Hukum Respublica; Vol. 23 No. 01 (2023): Jurnal Hukum Respublica; 57-68
Factors causing the crime of rape with violence committed jointly (study decision Number XX/Pid.B/2022/PN.Tlk? What is the perspective of Criminal Psychology towards the crime of rape with violence committed jointly (study decision Number xx/Pid.B/20...
PubMed
Catalytic vs. Inhibitory Promiscuity in Cytochrome P450s: Implications for Evolution of New Function
Biochemistry
Catalytically promiscuous enzymes are intermediates in the evolution of new function from an existing pool of protein scaffolds. However, promiscuity will only confer an evolutionary advantage if other useful properties are not compromised, or if the...
PubMed
Monitoring drug promiscuity over time
F1000Res
Drug promiscuity and polypharmacology are much discussed topics in pharmaceutical research. Experimentally, promiscuity can be studied by profiling of compounds on arrays of targets. Computationally, promiscuity rates can be estimated by mining of co...
PubMed
Prediction of Promiscuity Cliffs Using Machine Learning
Mol Inform
Compounds with the ability to interact with multiple targets, also called promiscuous compounds, provide the basis for polypharmacological drug discovery. In recent years, a plethora of structural analogs with different promiscuity has been identifie...
PubMed
Female Economic Dependence and the Morality of Promiscuity
Arch Sex Behav
In environments in which female economic dependence on a male mate is higher, male parental investment is more essential. In such environments, therefore, both sexes should value paternity certainty more and thus object more to promiscuity (because p...
PubMed
Determining the Degree of Promiscuity of Extensively Assayed Compounds
PLoS One
In the context of polypharmacology, an emerging concept in drug discovery, promiscuity is rationalized as the ability of compounds to specifically interact with multiple targets. Promiscuity of drugs and bioactive compounds has thus far been analyzed...
PubMed
Promiscuity progression of bioactive compounds over time
F1000Res
In the context of polypharmacology, compound promiscuity is rationalized as the ability of small molecules to specifically interact with multiple targets. To study promiscuity progression of bioactive compounds in detail, nearly 1 million compounds a...
PubMed
Evolution of female promiscuity in Passerides songbirds
BMC Evol Biol
BACKGROUND: Female promiscuity is highly variable among birds, and particularly among songbirds. Comparative work has identified several patterns of covariation with social, sexual, ecological and life history traits. However, it is unclear whether t...
PubMed
Data structures for compound promiscuity analysis: promiscuity cliffs, pathways and promiscuity hubs formed by inhibitors of the human kinome
Future Sci OA
AIM: A large collection of promiscuity cliffs (PCs), PC pathways (PCPs) and promiscuity hubs (PHs) formed by inhibitors of human kinases is made freely available. METHODOLOGY: Inhibitor PCs were systematically identified and organized in network repr...
PubMed
PubChem promiscuity: a web resource for gathering compound promiscuity data from PubChem
Bioinformatics
Summary: Promiscuity counts allow for a better understanding of a compound's assay activity profile and drug potential. Although PubChem contains a vast amount of compound and assay data, it currently does not have a convenient or efficient meth...
PubMed
Quantifying and Predicting the Promiscuity and Isoform Specificity of Small-Molecule Cytochrome P450 Inhibitors
Drug Metab Dispos
Drug promiscuity (i.e., inhibition of multiple enzymes by a single compound) is increasingly recognized as an important pharmacological consideration in the drug development process. However, systematic studies of functional or physicochemical charac...
PubMed
High-resolution view of compound promiscuity
F1000Res
Compound promiscuity is defined as the ability of a small molecule to specifically interact with multiple biological targets. So-defined promiscuity is relevant for drug discovery because it provides the molecular basis of polypharmacology, which is ...
PubMed
High Impact: The Role of Promiscuous Binding Sites in Polypharmacology
Molecules
The literature focuses on drug promiscuity, which is a drug’s ability to bind to several targets, because it plays an essential role in polypharmacology. However, little work has been completed regarding binding site promiscuity, even though its pr...
PubMed
Catalytic site flexibility facilitates the substrate and catalytic promiscuity of Vibrio dual lipase/transferase
Nat Commun
Although enzyme catalysis is typified by high specificity, enzymes can catalyze various substrates (substrate promiscuity) and/or different reaction types (catalytic promiscuity) using a single active site. This interesting phenomenon is widely distr...
PubMed
A Measure of the Promiscuity of Proteins and Characteristics of Residues in the Vicinity of the Catalytic Site That Regulate Promiscuity
PLoS One
Promiscuity, the basis for the evolution of new functions through ‘tinkering’ of residues in the vicinity of the catalytic site, is yet to be quantitatively defined. We present a computational method Promiscuity Indices Estimator (PROMISE) - base...
PubMed
Promiscuity, impersonation and accommodation: evolution of plant specialized metabolism
Curr Opin Struct Biol
Specialized metabolic enzymes and metabolite diversity evolve through a variety of mechanisms including promiscuity, changes in substrate specificity, modifications of gene expression and gene duplication. For example, gene duplication and substrate ...
PubMed
Equivalent T Cell Epitope Promiscuity in Ecologically Diverse Human Pathogens
PLoS One
BACKGROUND: The HLA (human leukocyte antigen) molecules that present pathogen-derived epitopes to T cells are highly diverse. Correspondingly, many pathogens such as HIV evolve epitope variants in order to evade immune recognition. In contrast, anoth...
PubMed
Modulating and evaluating receptor promiscuity through directed evolution and modeling
Protein Eng Des Sel
The promiscuity of G-protein-coupled receptors (GPCRs) has broad implications in disease, pharmacology and biosensing. Promiscuity is a particularly crucial consideration for protein engineering, where the ability to modulate and model promiscuity is...