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Vocational education policy white paper vol. 1 nomor 4 tahun 2019 : menyongsong bonus demografi penduduk dengan peningkatan kualitas sumber daya lulusan SMK
Indonesia is predicted to experience population demographic bonuses from 2030 to 2040. In order for
Indonesia to reap the maximum benefits from the demographic bonus, the availability of abundant human resources
in productive age must be balanced w...
PubMed
The Structure, Distribution and Evolution of the Ta1 Retrotransposable Element Family of Arabidopsis Thaliana
Genetics
The Ta1 elements are a low copy number, copia-like retrotransposable element family of Arabidopsis thaliana. Six Ta1 insertions comprise all of the Ta1 element copies found in three geographically diverse A. thaliana races. These six elements occupy ...
PubMed
Brain Histamine Modulates the Antidepressant-Like Effect of the 3-Iodothyroacetic Acid (TA1)
Front Cell Neurosci
3-iodothyroacetic acid (TA1), an end metabolite of thyroid hormone, has been shown to produce behavioral effects in mice that are dependent on brain histamine. We now aim to verify whether pharmacologically administered TA1 has brain bioavailability ...
PubMed
Fitness cost of LINE-1 (L1) activity in humans
Proc Natl Acad Sci U S A
The self-replicating LINE-1 (L1) retrotransposon family is the dominant retrotransposon family in mammals and has generated 30–40% of their genomes. Active L1 families are present in modern mammals but the important question of whether these curren...
PubMed
3-iodothyroacetic acid, a metabolite of thyroid hormone, induces itch and reduces threshold to noxious and to painful heat stimuli in mice
Br J Pharmacol
BACKGROUND AND PURPOSE: Itch is associated with increased sensitization to nociceptive stimuli. We investigated whether 3-iodothyroacetic acid (TA1), by releasing histamine, induces itch and increases sensitization to noxious and painful heat stimuli...
PubMed
Tissue distribution of the T cell activation antigen Ta1. Serological, immunohistochemical and biochemical investigations.
Clin Exp Immunol
The recently described Ta1 antigen is expressed by activated T cells in vitro and in vivo, as observed in patients with certain immune-mediated diseases, such as multiple sclerosis. In this paper we report on the tissue distribution of the Ta1 antige...
PubMed
Redox Properties of 3-Iodothyronamine (T1AM) and 3-Iodothyroacetic Acid (TA1)
Int J Mol Sci
3-iodothyronamine (T1AM) and 3-iodothyroacetic acid (TA1) are thyroid-hormone-related compounds endowed with pharmacological activity through mechanisms that remain elusive. Some evidence suggests that they may have redox features. We assessed the ch...
PubMed
Hot Deformation Behavior of TA1 Prepared by Electron Beam Cold Hearth Melting with a Single Pass
Materials (Basel)
The Gleeble-3800 thermal simulator was used for hot compression simulation to understand the hot deformation performance of TA1 prepared by the single-pass electron beam cold hearth (EB) process. The deformation degree is 50% on a thermal simulator w...
PubMed
Histamine mediates behavioural and metabolic effects of 3-iodothyroacetic acid, an endogenous end product of thyroid hormone metabolism
Br J Pharmacol
BACKGROUND AND PURPOSE: 3-Iodothyroacetic acid (TA1) is an end product of thyroid hormone metabolism. So far, it is not known if TA1 is present in mouse brain and if it has any pharmacological effects. EXPERIMENTAL APPROACH: TA1 levels in mouse brain...
PubMed
Immunopotentiator Thymosin Alpha-1 Promotes Neurogenesis and Cognition in the Developing Mouse via a Systemic Th1 Bias
Neurosci Bull
In early life, the immune system plays an essential role in brain development. In our study, the immunopotentiator thymosin alpha-1 (Ta1) was peripherally administered to neonatal mice to explore whether the peripheral immunopotentiator affects neuro...
PubMed
Trichoderma asperellum Ta1 Alleviates Root Rot Caused by Fusarium solani and Promotes the Growth of Panax notoginseng
J Fungi (Basel)
Panax notoginseng is a traditional medicinal and food-homologous plant in China; however, root rot, primarily caused by Fusarium solani, has become a devastating disease that severely compromises the yield and quality of P. notoginseng. In this study...
PubMed
Construction of a Symbiotically Effective Strain of Rhizobium leguminosarum bv. trifolii with Increased Nodulation Competitiveness
Appl Environ Microbiol
Genes involved in nodulation competitiveness (tfx) were inserted by marker exchange into the genome of the effective strain Rhizobium leguminosarum bv. trifolii TA1. Isogenic strains of TA1 were constructed which differed only in their ability to pro...
PubMed
Mitochondrial H(2)S(n)-Mediated Anti-Inflammatory Theranostics
Nanomicro Lett
The insistent demand for space-controllable delivery, which reduces the side effects of non-steroidal anti-inflammatory drugs (NSAIDs), has led to the development of a new theranostics-based approach for anti-inflammatory therapy. The current anti-in...
PubMed
Improving the binding affinity of an antibody using molecular modeling and site-directed mutagenesis.
Protein Sci
Activated Factor X releases F1.2, a 271-amino acid peptide, from the amino terminus of prothrombin during blood coagulation. A nine-amino acid peptide, C9 (DSDRAIEGR), corresponding to the carboxyl terminus of F1.2 was synthesized and used to produce...
PubMed
Novel Small-Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics
Circ Heart Fail
Current heart failure therapies unload the failing heart without targeting the underlying problem of reduced cardiac contractility. Traditional inotropes (ie, calcitropes) stimulate contractility via energetically costly augmentation of calcium cycli...
PubMed
A Superfamily of Arabidopsis Thaliana Retrotransposons
Genetics
We describe a superfamily of Arabidopsis thaliana retrotransposable elements that consists of at least ten related families designated Ta1-Ta10. The Ta1 family has been described previously. Two genomic clones representing the Ta2 and Ta3 elements we...
PubMed
Peptides disrupting TM4SF3 interaction with AR or AR-V7 block prostate cancer cell proliferation
Endocr Oncol
Androgen receptor (AR) plays a vital role in the development and progression of prostate cancer from the primary stage to the usually lethal stage known as castration-resistant prostate cancer (CRPC). Constitutively active AR splice variants (AR-Vs) ...
PubMed
Efficacy of thymosin α1 and interferon α for the treatment of severe acute pancreatitis in a rat model
Mol Med Rep
The present study aimed to investigate the effects of treatment with thymosin α1 (TA1) or interferon α (IFNα) following the establishment of severe acute pancreatitis (SAP) in rats. A total of 144 Sprague-Dawley rats were randomly divided into fou...
PubMed
A pilot trial of Thymalfasin (Ta1) to prevent covid-19 infection and morbidities in renal dialysis patients: Preliminary report()
Int Immunopharmacol
PURPOSE: Patients with end-stage renal disease (ESRD) on hemodialysis (HD) are considered particularly susceptible to infection with SARS-CoV2 on the basis of the immunodeficiency associated with advanced age, comorbidity burden, medication use, and ...
PubMed
Adaptive Mutations in a Human Immunodeficiency Virus Type 1 Envelope Protein with a Truncated V3 Loop Restore Function by Improving Interactions with CD4
J Virol
We previously reported that a human immunodeficiency virus type 1 (HIV-1) clade B envelope protein with a severely truncated V3 loop regained function after passage in tissue culture. The adapted virus, termed TA1, retained the V3 truncation, was exq...