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# Judul Penulis Tahun Akses
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Quantification of Andrographolide Isolated from Andrographis paniculata Nees Obtained from Traditional Market in Yogyakarta Using Validated HPLC

Indonesian Journal of Chemistry; Vol 16, No 2 (2016); 190-197
Universitas Gadjah Mada, 2018DOI: 10.22146/ijc.21163http://creativecommons.org/licenses/by-nc-nd/4.0
This research was aimed to quantification of andrographolide isolated from A. paniculata Ness found in traditional market in Yogyakarta using validated HPLC to obtain high level content of andrographolide. The extraction of andrographolide from A. pa...
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PubMed

Andrographolide induces apoptotic and non-apoptotic death and enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in gastric cancer cells

Oncol Lett
Spandidos Publications, 2017DOI: 10.3892/ol.2017.5923Copyright © 2017, Spandidos Publications
Andrographolide, a natural compound isolated from Andrographis paniculata, has been reported to possess antitumor activity. In the present study, the effect of andrographolide in human gastric cancer (GC) cells was investigated. Andrographolide induc...
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PubMed

Development of a Bifunctional Andrographolide-Based Chemical Probe for Pharmacological Study

PLoS One
PLOS, 2016DOI: 10.1371/journal.pone.0152770https://creativecommons.org/licenses/by/4.0/
Andrographolide (ANDRO) is a lactone diterpenoid compound present in the medicinal plant Andrographis paniculata which is clinically applied for multiple human diseases in Asia and Europe. The pharmacological activities of andrographolide have been w...
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PubMed

Lipase catalyzed synthesis of antimicrobial andrographolide derivatives

Data Brief
Elsevier, 2018DOI: 10.1016/j.dib.2018.03.103https://creativecommons.org/licenses/by/4.0/
In this data article we describe screening of various lipases for the regioselective acylation of Andrographolide. Each lipase was screened with seven acyl donors. Amano lipase AK from Pseudomonas fluorescens was used for the synthesis of two new acy...
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PubMed

Inhibition of NF-κB Expression and Allergen-induced Airway Inflammation in a Mouse Allergic Asthma Model by Andrographolide

Cell Mol Immunol
Nature Publishing Group, 2009DOI: 10.1038/cmi.2009.49Copyright © 2009 The Chinese Society of Immunology
Andrographolide from traditional Chinese herbal medicines previously showed it possesses a strong anti-inflammatory activity. In present study, we investigated whether Andrographolide could inhibit allergen-induced airway inflammation and airways hyp...
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PubMed

Effect of andrographolide and deep eutectic solvent extracts of Andrographis paniculata on human coronavirus organ culture 43 (HCoV-OC43)

Phytomedicine
2023DOI: 10.1016/j.phymed.2023.154708© 2023 Elsevier GmbH. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
BACKGROUND: Andrographis paniculata (Burm. f.) Nees has demonstrated potential for treating infections caused by coronaviruses. However, no antiviral activity of andrographolide or A. paniculata extracts against human coronavirus organ culture 43 (HC...
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PubMed

Andrographolide suppresses the migratory ability of human glioblastoma multiforme cells by targeting ERK1/2-mediated matrix metalloproteinase-2 expression

Oncotarget
Impact Journals, LLC, 2017DOI: 10.18632/oncotarget.22407https://creativecommons.org/licenses/by/3.0/
Glioblastoma multiforme (GBM) can be a fatal tumor because of difficulties in treating the related metastasis. Andrographolide is the bioactive component of the Andrographis paniculata. Andrographolide possesses the anti-inflammatory activity and inh...
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PubMed

Andrographolide sulfate inhibited NF-κB activation and alleviated pneumonia induced by poly I:C in mice

J Pharmacol Sci
2020DOI: 10.1016/j.jphs.2020.08.005© 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
Pneumonia is a common illness that continues to be the major killer of remaining to be a significant source of morbidity and mortality in the patient population. Many microorganisms cause pneumonia, and now concern is turning to the importance of the...
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PubMed

Andrographis paniculata Extract and Andrographolide Modulate the Hepatic Drug Metabolism System and Plasma Tolbutamide Concentrations in Rats

Evid Based Complement Alternat Med
Wiley, 2013DOI: 10.1155/2013/982689https://creativecommons.org/licenses/by/3.0/
Andrographolide is the most abundant terpenoid of A. paniculata which is used in the treatment of diabetes. In this study, we investigated the effects of A. paniculata extract (APE) and andrographolide on the expression of drug-metabolizing enzymes i...
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PubMed

Andrographolide suppresses the expression of inducible nitric oxide synthase in macrophage and restores the vasoconstriction in rat aorta treated with lipopolysaccharide

Br J Pharmacol
Wiley, 1998DOI: 10.1038/sj.bjp.0702073Copyright 1998, Nature Publishing Group
1. We investigated whether andrographolide, a diterpenoid lactone found at Andrographis paniculata, influences the induction of the inducible nitric oxide synthase (iNOS) in RAW264.7 cells activated by bacterial endotoxin (LPS), as well as in the rat...
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PubMed

In silico and in vitro studies on the anti-cancer activity of andrographolide targeting survivin in human breast cancer stem cells

PLoS One
PLOS, 2020DOI: 10.1371/journal.pone.0240020https://creativecommons.org/licenses/by/4.0/
Breast cancer stem cells (BCSCs) express high levels of the anti-apoptotic protein, survivin. This study aimed to discover a natural active compound with anti-cancer properties that targeted survivin in human breast cancer stem cells. From the seven ...
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PubMed

Andrographolide protects against cigarette smoke-induced oxidative lung injury via augmentation of Nrf2 activity

Br J Pharmacol
Wiley, 2013DOI: 10.1111/bph.12054British Journal of Pharmacology © 2013 The British Pharmacological Society
BACKGROUND AND PURPOSE: Cigarette smoke is a major cause for chronic obstructive pulmonary disease (COPD). Andrographolide is an active biomolecule isolated from the plant Andrographis paniculata. Andrographolide has been shown to activate nuclear fa...
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PubMed

Andrographolide alleviates Parkinsonism in MPTP‐PD mice via targeting mitochondrial fission mediated by dynamin‐related protein 1

Br J Pharmacol
Wiley, 2019DOI: 10.1111/bph.14823© 2019 The British Pharmacological Society
BACKGROUND AND PURPOSE: Accumulating evidence indicates that mitochondrial dynamics play an important role in the progressive deterioration of dopaminergic neurons. Andrographolide has been found to exert neuroprotective effects in several models of ...
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PubMed

Andrographolide induces DNA damage in prostate cancer cells

Oncotarget
Impact Journals, LLC, 2019DOI: 10.18632/oncotarget.26628https://creativecommons.org/licenses/by/3.0/
Prostate cancer (PCa) is the most common diagnosed cancer and is the third cause of cancer mortality in men in the USA. Andrographolide, a diterpenoid lactone isolated from Andrographis paniculata, has shown to possess anticarcinogenic activity in a ...
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PubMed

Andrographolide Inhibits Cholangiocarcinoma Cell Migration by Down-Regulation of Claudin-1 via the p-38 Signaling Pathway

Front Pharmacol
Frontiers Media SA, 2019DOI: 10.3389/fphar.2019.00827https://creativecommons.org/licenses/by/4.0/
Andrographolide, a bioactive phytochemical from Andrographis paniculata, is emerging as a promising anticancer agent against various cancers. This study aims to investigate anticancer activities of andrographolide against cholangiocarcinoma (CCA) and...
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PubMed

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis

Cell Death Dis
Nature Publishing Group, 2019DOI: 10.1038/s41419-019-2195-8http://creativecommons.org/licenses/by/4.0/
Radiation-induced lung injury (RILI) is one of the most common and fatal complications of thoracic radiotherapy, whereas no effective interventions are available. Andrographolide, an active component extracted from Andrographis paniculate, is prescri...
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PubMed

Andrographolide Inhibits Biofilm and Virulence in Listeria monocytogenes as a Quorum-Sensing Inhibitor

Molecules
Multidisciplinary Digital Publishing Institute (MDPI), 2022DOI: 10.3390/molecules27103234https://creativecommons.org/licenses/by/4.0/
Listeria monocytogenes is a major foodborne pathogen that can cause listeriosis in humans and animals. Andrographolide is known as a natural antibiotic and exhibits good antibacterial activity. We aimed to investigate the effect of andrographolide on...
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PubMed

Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism

Molecules
Multidisciplinary Digital Publishing Institute (MDPI), 2020DOI: 10.3390/molecules26010005http://creativecommons.org/licenses/by/4.0/
Andrographolide is a labdane diterpene and the main active ingredient isolated from the herb Andrographis paniculata. Andrographolide possesses diverse biological effects including anti-inflammatory, antioxidant, and antineoplastic properties. Clinic...
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PubMed

Andrographolide Induces ROS-Mediated Cytotoxicity, Lipid Peroxidation, and Compromised Cell Integrity in Saccharomyces cerevisiae

Antioxidants (Basel)
Multidisciplinary Digital Publishing Institute (MDPI), 2023DOI: 10.3390/antiox12091765https://creativecommons.org/licenses/by/4.0/
Andrographolide, a bioactive compound found in Andrographis paniculata, has gained significant attention for its potential therapeutic properties. Despite its promising benefits, the understanding of its side effects and underlying mechanisms remains...
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PubMed

Andrographolide drives dual apoptosis and ferroptosis via caspase-3 and FACL4 in T-ALL cell lines

Int J Hematol
2025DOI: 10.1007/s12185-025-04044-7https://creativecommons.org/licenses/by/4.0/
This study investigated the anti-tumor effects of andrographolide, a diterpene lactone derived from Andrographis paniculata, on T-cell acute lymphoblastic leukemia (T-ALL) cells. Andrographolide induced dose-dependent cytotoxicity and morphological c...
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