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Analytical Method Validation and Determination of Pyridoxine, Nicotinamide, and Caffeine in Energy Drinks Using Thin Layer Chromatography-Densitometry
Indonesian Journal of Chemistry; Vol 15, No 1 (2015); 9-15
Food supplement which contains vitamins and stimulants such as caffeine were classified as energy drink. TLC-densitometry method was chosen to determine the pyridoxine, nicotinamide, and caffeine in the energy drink sample. TLC plates of silica gel 6...
PubMed
Chronic voluntary caffeine intake in male Wistar rats reveals individual differences in addiction-like behavior
Pharmacol Biochem Behav
Caffeine is the most widely consumed psychoactive substance in the world. However, there is controversy about whether becoming addicted to caffeine is possible and a lack of well-established animal models to examine caffeine consumption. The present ...
PubMed
Habitual Caffeine Consumption and Training Status Affect the Ergogenicity of Acute Caffeine Intake on Exercise Performance
Sports Health
BACKGROUND: Acute caffeine ingestion can improve exercise performance. Interplay between caffeine habituation and training status on the performance-enhancing effect of caffeine is unknown. HYPOTHESIS: Habitual caffeine consumption and training statu...
PubMed
Inconsistency in the Ergogenic Effect of Caffeine in Athletes Who Regularly Consume Caffeine: Is It Due to the Disparity in the Criteria That Defines Habitual Caffeine Intake?
Nutrients
Caffeine is the most popular psychoactive substance in the world, and data suggests that it is widely used by athletes before competition to enhance physical and mental performance. The high number of athletes that regularly use caffeine suggests the...
PubMed
Salivary caffeine in Parkinson’s disease
Sci Rep
We aimed to investigate salivary caffeine content, caffeine absorption and metabolism in Parkinson’s disease (PD) and verify whether salivary caffeine can be used as a biomarker of PD. We enrolled 98 PD patients and 92 healthy subjects. Caffeine an...
PubMed
Common questions and misconceptions about caffeine supplementation: what does the scientific evidence really show?
J Int Soc Sports Nutr
Caffeine is a popular ergogenic aid that has a plethora of evidence highlighting its positive effects. A Google Scholar search using the keywords “caffeine” and “exercise” yields over 200,000 results, emphasizing the extensive research on thi...
PubMed
Caffeine Content Labeling: A Missed Opportunity for Promoting Personal and Public Health
J Caffeine Res
Current regulation of caffeine-containing products is incoherent, fails to protect consumers' interests, and should be modified in multiple ways. We make the case for one of the regulatory reforms that are needed: all consumable products contain...
PubMed
Characterization of Individuals Seeking Treatment for Caffeine Dependence
Psychol Addict Behav
Previous investigations have identified individuals who meet criteria for DSM-IV-TR substance dependence as applied to caffeine, but there is little research on treatments for caffeine dependence. This study aimed to thoroughly characterize individua...
PubMed
Effects of chronic caffeine exposure during adolescence and subsequent acute caffeine challenge during adulthood on rat brain serotonergic systems
Neuropharmacology
Caffeine is the most commonly used drug in the world. However, animal studies suggest that chronic consumption of caffeine during adolescence can result in enhanced anxiety-like behavioral responses during adulthood. One mechanism through which chron...
PubMed
Genetics of caffeine consumption and responses to caffeine
Psychopharmacology (Berl)
RATIONALE: Caffeine is widely consumed in foods and beverages and is also used for a variety of medical purposes. Despite its widespread use, relatively little is understood regarding how genetics affects consumption, acute response, or the long-term...
PubMed
Estimate the prevalence of daily caffeine consumption, caffeine use disorder, caffeine withdrawal and perceived harm in Iran: a cross-sectional study
Sci Rep
One of the informal diagnoses in DSM-5 is Caffeine Use Disorder (CUD). CUD and high levels of caffeine consumption could impact mental health conditions. This study aimed to estimate the prevalence of CUD, caffeine consumption, caffeine-related harms...
PubMed
Caffeine induces CYP1A2 expression in rat hepatocytes but not in human hepatocytes
Drug Metab Lett
Caffeine is the active constituent in coffee. Continual consumption of caffeine can lead to an attenuated response also known as tolerance. Results from rat studies have shown that caffeine is an inducer of CYP1A2, the enzyme responsible for caffeine...
PubMed
Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study
Int J Pediatr
Background. Caffeine is widely used to treat apnea of prematurity. Here, we evaluated the efficacy of early caffeine (1-2 DOL) in decreasing the incidence of adverse neonatal outcomes. Methods. A retrospective cohort was used to compare the neonatal ...
PubMed
Effects of caffeine on sleep quality and daytime functioning
Risk Manag Healthc Policy
Caffeine (particularly in the form of coffee) is one of the most widely consumed stimulants in the world, with 90% of American adults consuming caffeine-infused beverages almost daily. While there is substantial evidence that caffeine enhances perfor...
PubMed
Caffeine as an opioid analgesic adjuvant in fibromyalgia
J Pain Res
BACKGROUND: Caffeine’s properties as an analgesic adjuvant with nonsteroidal anti-inflammatory drugs/acetaminophen are well documented. However, little clinical research has explored caffeine’s effects on opioid analgesia. This study assessed the...
PubMed
Effects of Caffeine and Acute Aerobic Exercise on Working Memory and Caffeine Withdrawal
Sci Rep
Studies show that a single bout of exercise confers cognitive benefits. However, many individuals use psychoactive substances such as caffeine to enhance cognitive performance. The effects of acute exercise in comparison to caffeine on cognition rema...
PubMed
The caffeine dilemma: unraveling the intricate relationship between caffeine use disorder, caffeine withdrawal symptoms and mental well-being in adults
Public Health Nutr
OBJECTIVE: This study aimed to explore the relationship between caffeine use disorder (CUD), caffeine withdrawal symptoms and the prevalence of depression, anxiety and stress (DASS) in adults. DESIGN: The study utilised a cross-sectional design to as...
PubMed
Comparing Salivary Caffeine Kinetics of (13)C and (12)C Caffeine for Gastric Emptying of 50 mL Water
Pharmaceutics
Gastric water emptying as a critical parameter for oral drug absorption can be investigated by several imaging techniques or by the interpretation of pharmacokinetics of appropriate substances. Recently introduced salivary caffeine kinetics is a valu...
PubMed
Clinical and Physiological Correlates of Caffeine and Caffeine Metabolites in Primary Insomnia
J Clin Sleep Med
OBJECTIVES: To explore the relationship between plasma concentrations of caffeine and subjective and polysomnographic measures of sleep in both good sleeper controls (GSC) and individuals with primary insomnia (PI), following the consumption of low-m...
PubMed
Caffeine renal clearance and urine caffeine concentrations during steady state dosing. Implications for monitoring caffeine intake during sports events.
Br J Clin Pharmacol
1. Relationships between the plasma and urine concentrations and clearances of caffeine over successive dosage intervals at steady-state were investigated in six healthy volunteers administered caffeine, 150 mg 8 hourly for 6 days. 2. There was marke...
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