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Chalcone Based Colorimetric Sensor for Anions: Experimental and TD-DFT Study
Indonesian Journal of Chemistry; Vol 16, No 1 (2016); 80-86
The interactions between sensor chalcone of 3-(4-hydroxy-3-methoxyphenyl)-1-phenyl-2-propen-1-one (1) and anions (F–, Cl–, Br–, CN–, CO32–, and SO42–) have been experimentally and TD-DFT theoretically investigated. Sensor (1) showed a nak...
PubMed
Structural Elucidation of Chalcone Reductase and Implications for Deoxychalcone Biosynthesis
J Biol Chem
4,2′,4′,6′-tetrahydroxychalcone (chalcone) and 4,2′,4′-trihydroxychalcone (deoxychalcone) serve as precursors of ecologically important flavonoids and isoflavonoids. Deoxychalcone formation depends on chalcone synthase and chalcone reductas...
PubMed
Trans-chalcone increases p53 activity via DNAJB1/HSP40 induction and CRM1 inhibition
PLoS One
Naturally-occurring chalcones and synthetic chalcone analogues have been demonstrated to have many biological effects, including anti-inflammatory, anti-malarial, anti-fungal, and anti-oxidant/anti-cancerous activities. Compared to other chalcones, t...
PubMed
Trans-chalcone enhances insulin sensitivity through the miR-34a/SIRT1 pathway
Iran J Basic Med Sci
OBJECTIVE(S): Trans-chalcone as the parent member of the chalcone series reduces circulating levels of insulin and glucose. However, the cellular mechanism of these effects is poorly understood. Sirtuin 1 (SIRT1) as a direct target of miR-34a control...
PubMed
Chalcone isomerase family and fold: No longer unique to plants
Protein Sci
Chalcone isomerase, an enzyme in the isoflavonoid pathway in plants, catalyzes the cyclization of chalcone into (2S)-naringenin. Chalcone isomerase sequence family and three-dimensional fold appeared to be unique to plants and has been proposed as a ...
PubMed
Chalcone: A Privileged Structure in Medicinal Chemistry
Chem Rev
Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to...
PubMed
A chalcone inhibits the growth and metastasis of KYSE-4 esophageal cancer cells
J Int Med Res
OBJECTIVE: To investigate the in vitro and in vivo anticancer effects of a chalcone against KYSE-4 esophageal cancer cells. METHODS: A chalcone was synthesized via the molecular hybridization strategy based on the anticancer activity of chalcone and ...
PubMed
In vivo Study of Chalcone Loaded Carbon Dots for Enhancement of Anticancer and Bioimaging Potencies
Nanotheranostics
The fluorescent imaging and drug delivery utilizing carbon dots nanomaterials (CDs) have attracted tremendously due to their unique optical ability and outstanding biocompatibility. Herein, we reported a new design of chalcone-loaded carbon dots (Cha...
PubMed
Synthesis and Evaluation of Chalcone Derivatives as Novel Sunscreen Agent
Molecules
Ultraviolet (UV) irradiation is a serious problem for skin health thus the interest in the research to develop sunscreen agent has been increasing. Chalcone is a promising compound to be developed as its chromophore absorbs in the UV region. Therefor...
PubMed
Chalcone-9: a novel inhibitor of the JAK-STAT pathway with potent anti-cancer effects in triple-negative breast cancer cells
Pharmacol Rep
BACKGROUND: Breast cancer remains the leading cause of cancer incidence and mortality among women worldwide, with triple-negative breast cancer (TNBC) posing significant treatment challenges. The dysregulation of the Janus kinase/signal transducer an...
PubMed
Development and validation of a UV–Vis spectrophotometric method for estimation of total content of chalcone
MethodsX
In this study, a straightforward spectrophotometric method was developed for quantifying the total content of chalcones in a sample. The method exhibits linearity, accuracy, precision, repeatability, and enables the estimation of total chalcone conte...
PubMed
Biochemical, immunological, and immunocytochemical evidence for the association of chalcone synthase with endoplasmic reticulum membranes.
Proc Natl Acad Sci U S A
Chalcone synthase [naringenin-chalcone synthase; malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing), E.C. 2.3.1.74], the key enzyme of flavonoid pathways that was believed to be soluble, has been localized on ribosome-bearing endoplasmic reti...
PubMed
Probing Endothelial Cell Mechanics Through Connexin 43 Disruption
Exp Mech
The endothelium has been established to generate intercellular stresses and suggested to transmit these intercellular stresses through cell-cell junctions, such as VE-Cadherin and ZO-1, for example. Although the previously mentioned molecules reflect...
PubMed
Design and synthesis of chalcone derivatives as potential non-purine xanthine oxidase inhibitors
Springerplus
BACKGROUND: Based on some previous research, the chalcone derivatives exhibited potent xanthine oxidase inhibitory activity, e.g. sappanchalcone (7), with IC(50) value of 3.9 μM, was isolated from Caesalpinia sappan. Therefore, objectives of this r...
PubMed
Privileged Scaffold Chalcone: Synthesis, Characterization and Its Mechanistic Interaction Studies with BSA Employing Spectroscopic and Chemoinformatics Approaches
ACS Omega
[Image: see text] Chalcone, a privileged structure, is considered as an effective template in the field of medicinal chemistry for potent drug discovery. In the present study, a privileged template chalcone was designed, synthesized, and characterize...
PubMed
UV-induction of chalcone synthase mRNA in cell suspension cultures of Petroselinum hortense
Proc Natl Acad Sci U S A
DNAs complementary to poly(A)(+) mRNAs from UV-irradiated cell suspension cultures of parsley (Petroselinum hortense) were inserted into pBR322 and used to transform Escherichia coli strain RR1. A clone containing a DNA complementary to chalcone synt...
PubMed
Chalcone 9X Contributed to Repressing Glioma Cell Growth and Migration and Inducing Cell Apoptosis by Reducing FOXM1 Expression In Vitro and Repressing Tumor Growth In Vivo
Biomed Res Int
OBJECTIVE: Natural and synthetic chalcones played roles in inflammation and cancers. Chalcone 9X was an aromatic ketone that was found to inhibit cell growth of hepatic cancer and lung cancer cells. In this study, we wanted to investigate the functio...
PubMed
Chalcone-Acridine Hybrid Suppresses Melanoma Cell Progression via G2/M Cell Cycle Arrest, DNA Damage, Apoptosis, and Modulation of MAP Kinases Activity
Int J Mol Sci
This study was focused on investigating the antiproliferative effects of chalcone hybrids in melanoma cancer cells. Among seven chalcone hybrids, the chalcone-acridine hybrid 1C was the most potent and was selected for further antiproliferative mecha...
PubMed
Selective in vitro Synergistic Evaluation of Probiotic Tolerant morpholinyl- and 4-ethylpiperazinyl-Imidazole-chalcone Derivatives on Gastrointestinal System Pathogens
Curr Microbiol
Imidazole-chalcone compounds are recognised for their broad-spectrum antimicrobial properties. Probiotic-friendly, selective new-generation antimicrobials prove to be more efficient in combating gastrointestinal system pathogens. The aim of this stud...
PubMed
Structural and Interactional Analysis of the Flavonoid Pathway Proteins: Chalcone Synthase, Chalcone Isomerase and Chalcone Isomerase-like Protein
Int J Mol Sci
Chalcone synthase (CHS) and chalcone isomerase (CHI) catalyze the first two committed steps of the flavonoid pathway that plays a pivotal role in the growth and reproduction of land plants, including UV protection, pigmentation, symbiotic nitrogen fi...
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