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PubMed
Some Insults are Easier to Detect: The Embodied Insult Detection Effect
Front Psychol
In the present research we examined the effects of bodily experience on processing of insults in a series of semantic categorization tasks we call insult detection tasks (i.e., participants decided whether presented stimuli were insults or not). Two ...
PubMed
Intraoperative Secondary Insults during Orthopedic Surgery in Traumatic Brain Injury
J Neurosurg Anesthesiol
BACKGROUND: Secondary insults worsen outcomes after traumatic brain injury (TBI). However, data on intraoperative secondary insults are sparse. The primary aim of this study was to examine the prevalence of intraoperative secondary insults during ort...
PubMed
Smoking and exposure to racial insults among multiethnic youth in Jujuy, Argentina
Cancer Causes Control
PURPOSE: Exposure to racial insults among youth in Jujuy, Argentina, was examined as a factor associated with smoking behavior. METHODS: Youth sampled from eighth-grade classes in 27 randomly selected middle schools completed annual surveys in the ni...
PubMed
Developmental Programming, a Pathway to Disease
Endocrinology
Accumulating evidence suggests that insults occurring during the perinatal period alter the developmental trajectory of the fetus/offspring leading to long-term detrimental outcomes that often culminate in adult pathologies. These perinatal insults i...
PubMed
Effects of JAK2-STAT3 signaling after cerebral insults
JAKSTAT
The JAK2-STAT3 signaling pathway has been shown to regulate the expression of genes involved in cell survival, cell proliferation, cell-cycle progression, and angiogenesis in development and after cerebral insults. Until recently, little has been kno...
PubMed
Immune Challenges and Seizures: How Do Early Life Insults Influence Epileptogenesis?
Front Pharmacol
The development of epilepsy, a process known as epileptogenesis, often occurs later in life following a prenatal or early postnatal insult such as cerebral ischemia, stroke, brain trauma, or infection. These insults share common pathophysiological pa...
PubMed
Secondary insults prevalence, co-occurrence and relationship with outcome after severe TBI
Brain Spine
INTRODUCTION: Secondary insults due to high intracranial pressure (ICP), low cerebral perfusion pressure (CPP) and impaired cerebral pressure reactivity (PRx) predict outcome after severe traumatic brain injury (TBI). RESEARCH QUESTION: What is the p...
PubMed
Environmental insults: critical triggers for amyotrophic lateral sclerosis
Transl Neurodegener
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by a rapid loss of lower and upper motor neurons. As a complex disease, the ageing process and complicated gene-environment interactions are involved i...
PubMed
Management of hyponatraemia in patients with acute cerebral insults
Arch Dis Child
Hyponatraemia is a common finding in patients with acute cerebral insults. The main differential diagnosis is between syndrome of inappropriate ADH secretion and cerebral salt wasting. Our aim is to review the topic of hyponatraemia in patients with ...
PubMed
Vulnerability of the Hippocampus to Insults: Links to Blood–Brain Barrier Dysfunction
Int J Mol Sci
The hippocampus is a critical brain substrate for learning and memory; events that harm the hippocampus can seriously impair mental and behavioral functioning. Hippocampal pathophysiologies have been identified as potential causes and effects of a re...
PubMed
Perinatal insult dimensions and developmental trajectories of psychotic-like experiences
Schizophrenia (Heidelb)
Perinatal insults (e.g., obstetric complications, substance exposure) are increasing in prevalence and confer risk for psychotic-like experiences in offspring, contributing to a growing public health burden. Perinatal insults often co-occur, creating...
PubMed
Mast cell-derived neurotrophin 4 mediates allergen-induced airway hyperinnervation in early life
Mucosal Immunol
Asthma often progresses from early episodes of insults. How early life events connect to long-term airway dysfunction remains poorly understood. We demonstrated previously that increased neurotrophin 4 (NT4) levels following early life allergen expos...
PubMed
Impact on clinical outcome of secondary brain insults during the neurointensive care of patients with subarachnoid haemorrhage: a pilot study.
J Neurol Neurosurg Psychiatry
OBJECTIVE: To analyse the occurrence and influence on outcome of secondary brain insults during neurointensive care of patients with subarachnoid haemorrhage. METHODS: Sixty one seriously ill patients with subarachnoid haemorrhage with a poor neurolo...
PubMed
The role of peripheral inflammatory insults in Alzheimer’s disease: a review and research roadmap
Mol Neurodegener
Peripheral inflammation, defined as inflammation that occurs outside the central nervous system, is an age-related phenomenon that has been identified as a risk factor for Alzheimer’s disease. While the role of chronic peripheral inflammation has b...
PubMed
Machine Learning Based Prediction of Imminent ICP Insults During Neurocritical Care of Traumatic Brain Injury
Neurocrit Care
BACKGROUND: In neurointensive care, increased intracranial pressure (ICP) is a feared secondary brain insult in traumatic brain injury (TBI). A system that predicts ICP insults before they emerge may facilitate early optimization of the physiology, w...
PubMed
Systemic Prenatal Insults Disrupt Telencephalon Development
Epilepsy Behav
Infants born prematurely are prone to chronic neurologic deficits including cerebral palsy (CP), epilepsy, cognitive delay, behavioral problems, and neurosensory impairments. In affected children, imaging and neuropathological findings demonstrate si...
PubMed
Effect of Secondary Insults upon Aquaporin-4 Water Channels following Experimental Cortical Contusion in Rats
J Neurotrauma
Although secondary insults of hypoxia and hypotension (HH) are generally considered to cause fulminant brain edema in traumatic brain injury (TBI), the combined effect of TBI with HH on brain edema and specifically the expression of aquaporin-4 (AQP4...
PubMed
Adding insult to injury: the prognostic value of early secondary insults for survival after traumatic brain injury
J Neurol Neurosurg Psychiatry
OBJECTIVES—To assess the prognostic value of summary measures of secondary physiological insult in addition to baseline clinical variables for patients with traumatic brain injury.
METHODS—A series of 110 patients with traumatic brain injury ha...
PubMed
Effect of Appreciation for Indigenous Cultures and Exposure to Racial Insults on Alcohol and Drug use Initiation among Multiethnic Argentinean Youth
Prev Med
This study evaluated the effect of factors reflecting appreciation of Indigenous culture and racial insults on alcohol and drug use initiation among multi-ethnic youth in Jujuy, Argentina. Students were surveyed from 27 secondary schools that were ra...
PubMed
Developmental Seizures Induced by Common Early-Life Insults: Short- and Long-Term Effects on Seizure Susceptibility
Ment Retard Dev Disabil Res Rev
The immature brain is highly susceptible to seizures induced by a variety of insults, including hypoxia, fever, and trauma. Unlike early life epilepsy associated with congenital dysplasias or genetic abnormalities, insults induce a hyperexcitable sta...