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Synthesis and Characterization of Chitosan- Alginate for Controlled Release of Isoniazid Drug
Indonesian Journal of Chemistry; Vol 15, No 1 (2015); 16-21
The aim of this research was to synthesize and characterize chitosan-calcium alginate as matrix isoniazid encapsulation to produce controlled release isoniazid drug. The microparticles were evaluated for surface morphology, functional groups, size pa...
PubMed
Effect of prednisolone and rifampin on isoniazid metabolism in slow and rapid inactivators of isoniazid.
Antimicrob Agents Chemother
The effect of prednisolone and rifampin, alone and in combination, on the biodisposition of isoniazid in slow and rapid inactivators of isoniazid was investigated. In one investigation, we made serial determinations of plasma isoniazid concentrations...
PubMed
Effect of efavirenz-based antiretroviral therapy and high-dose rifampicin on the pharmacokinetics of isoniazid and acetyl-isoniazid
J Antimicrob Chemother
OBJECTIVES: To describe the pharmacokinetics of isoniazid and acetyl-isoniazid in TB/HIV-coinfected patients, and assess the effects of efavirenz co-administration and a 50% increase in the dose of rifampicin on the pharmacokinetic parameters of ison...
PubMed
Inhibition of the metabolism of paracetamol by isoniazid.
Br J Clin Pharmacol
1. The effect of isoniazid given daily for 7 days on paracetamol (acetaminophen) kinetics and metabolism was studied in 10 healthy volunteers. Paracetamol, 500 mg, was given before isoniazid, on day 7 of isoniazid administration, and 2 days after the...
PubMed
Global and Regional Burden of Isoniazid-Resistant Tuberculosis
Pediatrics
BACKGROUND: Isoniazid has been the backbone of tuberculosis chemotherapy for 6 decades. Resistance to isoniazid threatens the efficacy of treatment of tuberculosis disease and infection. To inform policies around treatment of tuberculosis disease and...
PubMed
Population Genetics Study of Isoniazid Resistance Mutations and Evolution of Multidrug-Resistant Mycobacterium tuberculosis
Antimicrob Agents Chemother
The molecular basis for isoniazid resistance in Mycobacterium tuberculosis is complex. Putative isoniazid resistance mutations have been identified in katG, ahpC, inhA, kasA, and ndh. However, small sample sizes and related potential biases in sample...
PubMed
Chronic dialysis, NAT2 polymorphisms, and the risk of isoniazid-induced encephalopathy – case report and literature review
BMC Nephrol
BACKGROUND: Isoniazid is the most widely used anti-tuberculosis agent, yet it may lead to life-threatening complications. CASE PRESENTATION: Here we report the case of a chronic hemodialysis patient who developed severe encephalopathy after the start...
PubMed
Association Between the Phenotype and Genotype of Isoniazid Resistance Among Mycobacterium tuberculosis Isolates in Thailand
Infect Drug Resist
PURPOSE: The emergence of isoniazid-resistant tuberculosis (HR-TB) is a global public health problem, causing treatment failure and high mortality rates. This study aimed to determine the minimal inhibitory concentration (MIC) of isoniazid and detect...
PubMed
The emergence of isoniazid-resistant cultures in patients with pulmonary tuberculosis during treatment with isoniazid alone or isoniazid plus PAS
Bull World Health Organ
Previous reports from the Tuberculosis Chemotherapy Centre, Madras, have described a comparison of four regimens (three of isoniazid alone and one of isoniazid plus PAS) in the treatment of pulmonary tuberculosis and an investigation of the serum iso...
PubMed
CYP2E1-dependent elevation of serum cholesterol, triglycerides, and hepatic bile acids by isoniazid
Toxicol Appl Pharmacol
Isoniazid is the first-line medication in the prevention and treatment of tuberculosis. Isoniazid is known to have a biphasic effect on the inhibition–induction of CYP2E1 and is also considered to be involved in isoniazid-induced hepatotoxicity. Ho...
PubMed
The pharmacokinetics of lopinavir/ritonavir when given with isoniazid in South African HIV-infected individuals.
Int J Tuberc Lung Dis
Isoniazid preventive therapy is recommended in patients on antiretroviral therapy with latent tuberculosis infection to prevent progression to active tuberculosis disease. Isoniazid inhibits CYP3A4, which metabolizes lopinavir. Administration of ison...
PubMed
Protective effects of salep against isoniazid liver toxicity in wistar rats
J Tradit Complement Med
INTRODUCTION: Isoniazid is a drug for treatment of tuberculosis. One of the main side effects of this drug is hepatotoxicity, which is a major cause of treatment interruption in tuberculosis. This study is about the preventive effect of Salep on this...
PubMed
Barriers in the implementation of isoniazid preventive therapy for people living with HIV in Northern Ethiopia: a mixed quantitative and qualitative study
BMC Public Health
BACKGROUND: Isoniazid preventive therapy is a key public health intervention for the prevention of tuberculosis disease among people living with HIV. Despite the confirmed efficacy of isoniazid preventive therapy and global recommendations existing f...
PubMed
Lansoprazole Ameliorates Isoniazid-Induced Liver Injury
Pharmaceuticals (Basel)
Isoniazid is a first-line drug in antitubercular therapy. Isoniazid is one of the most commonly used drugs that can cause liver injury or acute liver failure, leading to death or emergency liver transplantation. Therapeutic approaches for the prevent...
PubMed
Prevention of isoniazid tumorigenicity by antitoxicants of isoniazid in Swiss mice
J Cancer Res Clin Oncol
Effect of isoniazid on blood ammonia levels and protein biosynthesis in tissues of Swiss mice was studied. Isoniazid treatment resulted in an elevation of the blood ammonia. It inhibited the protein biosynthesis in lung and kidney tissues of Swiss mi...
PubMed
Redox Imbalance and Oxidative DNA Damage During Isoniazid Treatment of HIV-Associated Tuberculosis: A Clinical and Translational Pharmacokinetic Study
Front Pharmacol
BACKGROUND: The potential for hepatotoxicity during isoniazid-based tuberculosis (TB) treatment presents a major challenge for TB control programs worldwide. We sought to determine whether pharmacokinetic exposures of isoniazid and its metabolites we...
PubMed
Rate of inactivation of isoniazid in South Indian patients with pulmonary tuberculosis
Bull World Health Organ
A series of studies on the rate of inactivation of isoniazid in Indian patients with pulmonary tuberculosis in a 1-year comparison of four domiciliary chemotherapeutic regimens—three of isoniazid alone, either in moderate (HI-1 and HI-2 regimens) o...
PubMed
Isoniazid acetylation rates (phenotypes) of patients being treated for tuberculosis
Bull World Health Organ
Isoniazid therapy could be used more rationally if patients' isoniazid acetylation rates were known. To explore the clinical usefulness of a recently described simple method for acetylator phenotyping, acetylated and free isoniazid were measured...
PubMed
The pharmacokinetics of nevirapine when given with isoniazid in South African HIV-infected individuals
Int J Tuberc Lung Dis
Isoniazid preventive therapy is recommended in patients on antiretroviral therapy. Isoniazid inhibits CYP3A4, which metabolizes nevirapine. Administration of isoniazid may cause higher nevirapine concentrations and toxicity. We studied the effect of ...
PubMed
Treatment completion for latent tuberculosis infection: a retrospective cohort study comparing 9 months of isoniazid, 4 months of rifampin and 3 months of isoniazid and rifapentine
BMC Infect Dis
BACKGROUND: The U.S. Centers for Disease Control and Prevention (CDC) recommended a new regimen for treatment of latent tuberculosis (three months of weekly isoniazid and rifapentine) in late 2011. While completion rates of this regimen were reported...
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