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Jurnal Institusi
Copper and Cadmium Toxicity to Marine Phytoplankton, Chaetoceros gracilis and Isochrysis sp.
Indonesian Journal of Chemistry; Vol 15, No 2 (2015); 172-178
In Copper (Cu) based antifouling (AF) paints Cu was largely used as booster biocide after organotin was banned. Cu is micronutrient which is important in photosynthesis process because Cu is an essential metal as component of enzyme and electron tran...
Jurnal Institusi
Properties and Toxicity of Cobalt(II) Complex with 2,4,5-triphenyl-1H-imidazole Ligand
Indonesian Journal of Chemistry; Vol 16, No 3 (2016); 260-267
Binuclear cobalt(II) complex with 2,4,5-triphenyl-1H-imidazole ligand has been synthesized using reflux method. The yellowish green crystals with needle-like shape were obtained. Determination of molecular formula of the complex was carried out using...
Jurnal Institusi
Methylation of Eugenol Using Dimethyl Carbonate and Bentonite as Catalyst
Indonesian Journal of Chemistry; Vol 15, No 3 (2015); 256-262
Eugenol is a compound with a variety of reactive functional groups such as allyl, hydroxy and methoxy. The presence of the functional groups brings eugenol possible to undertake the transformation into various derivative compounds with diverse activi...
PubMed
Analysis of Ammonia Toxicity in Landfill Leachates
ISRN Toxicol
Toxicity identification evaluation (TIE) phase I manipulations and toxicity test with D. magna were conducted on leachates from an industrial waste landfill site in Japan. Physicochemical analysis detected heavy metals at concentrations insufficient ...
PubMed
Systematic identification of molecular targets and pathways related to human organ level toxicity
Chem Res Toxicol
Mechanisms leading to organ level toxicities are poorly understood. In this study we applied an integrated approach to deduce molecular targets and biological pathways involved in chemically-induced toxicity for eight common human organ level toxicit...
PubMed
A novel toxicity scoring system treating toxicity response as a quasi-continuous variable in Phase I clinical trials
Contemp Clin Trials
In almost all current Phase I designs, toxicity response is treated coarsely as a binary indicator of dose limiting toxicity (DLT) and a lot of useful toxicity information is discarded. We are the first to establish a novel toxicity scoring system to...
PubMed
Predictors of Financial Toxicity Trajectories in Patients With Pancreatic Cancer: A Latent Class Growth Analysis
Cancer Med
IMPORTANCE: Pancreatic cancer patients face varying medical expenses at different stages of treatment, resulting in dynamic changes in their financial toxicity. Longitudinal data collection is necessary to characterize the trajectory of these financi...
PubMed
Genetic and Biochemical Analysis of High Iron Toxicity in Yeast
J Biol Chem
Iron storage in yeast requires the activity of the vacuolar iron transporter Ccc1. Yeast with an intact CCC1 are resistant to iron toxicity, but deletion of CCC1 renders yeast susceptible to iron toxicity. We used genetic and biochemical analysis to ...
PubMed
Anti‐retinal Autoantibodies in Hydroxychloroquine Eye Toxicity
ACR Open Rheumatol
OBJECTIVE: Autoimmune retinopathy and hydroxychloroquine (HCQ)‐related retinal toxicity share many similarities, raising the possibility autoimmunity plays a role in HCQ retinopathy. The objective of this study is to determine whether patients diag...
PubMed
A latent profile analysis of financial toxicity and its association with anxiety and depression in patients with hematologic malignancies
Asia Pac J Oncol Nurs
OBJECTIVE: To identify latent subgroups of financial toxicity among patients with hematologic malignancies, examine associated sociodemographic and clinical predictors, and explore the relationship between financial toxicity and anxiety-depression sy...
PubMed
Financial Toxicity in Dementia Caregiving: Sociodemographic Predictors in a U.S. Nationally Representative Survey
Gerontologist
BACKGROUND AND OBJECTIVES: “Financial toxicity” describes the negative effects of medical expenses on financial security and health-related quality of life. Beyond dementia, financial toxicity is used to address the financial and health consequen...
PubMed
Characterizing clinical toxicity in cancer combination therapies
Bioinformatics
MOTIVATION: Predicting synergistic cancer drug combinations through computational methods offers a scalable approach to creating therapies that are more effective and less toxic. However, most algorithms focus solely on synergy without considering to...
PubMed
Development of an Objective Scoring System for Endoscopic Assessment of Radiation-Induced Upper Gastrointestinal Toxicity
Cancers (Basel)
SIMPLE SUMMARY: High-dose radiation therapy techniques have gained increasing interest in pancreatic cancer treatment, but toxicity to the upper gastrointestinal (GI) organs remains a major concern. We aimed to develop an objective toxicity scoring s...
PubMed
Cell toxicity mechanism and biomarker
Clin Transl Med
Cell toxicity may result in organ dysfunction and cause severe health problem. Recent studies revealed many toxicants may induced the over production of Nitric oxide, reactive oxygen species and the subsequent oxidative stress, cause cell toxicity. M...
PubMed
Risk-Group-Specific Dose Finding Based on an Average Toxicity Score
Biometrics
We propose a Bayesian dose-finding design that accounts for two important factors, the severity of toxicity and heterogeneity in patients’ susceptibility to toxicity. We consider toxicity outcomes with various levels of severity and define appropri...
PubMed
RAPID QUANTIFICATION OF MULTI-CRYOPROTECTANT TOXICITY USING AN AUTOMATED LIQUID HANDLING METHOD
Cryobiology
Cryopreservation in a vitrified state has vast potential for long-term storage of tissues and organs that may be damaged by ice formation. However, the toxicity imparted by the high concentration of cryoprotectants (CPAs) required to vitrify these sp...
PubMed
Too much of a good thing: defining antimicrobial therapeutic targets to minimize toxicity
Clin Pharmacol Ther
Antimicrobials are a common cause of drug toxicity. Understanding the relationship between systemic antimicrobial exposure and toxicity is necessary to enable providers to take a proactive approach to prevent undesired drug effects. When an exposure ...
PubMed
TDP-43 Toxicity in Yeast Is Associated with a Reduction in Autophagy, and Deletions of TIP41 and PBP1 Counteract These Effects
Viruses
When human TDP-43 is overexpressed in yeast it is toxic and forms cytoplasmic aggregates. The mechanism of this toxicity is unknown. Genetic screens for TDP-43 toxicity modifiers in the yeast system previously identified proteins, including PBP1, tha...
PubMed
Periodical assessment of genitourinary and gastrointestinal toxicity in patients who underwent prostate low-dose-rate brachytherapy
Radiat Oncol
BACKGROUND: To compare the periodical incidence rates of genitourinary (GU) and gastrointestinal (GI) toxicity in patients who underwent prostate low-dose-rate brachytherapy between the monotherapy group (seed implantation alone) and the boost group ...
PubMed
Exploration of Computational Approaches to Predict the Toxicity of Chemical Mixtures
Toxics
Industrial advances have led to generation of multi-component chemicals, materials and pharmaceuticals which are directly or indirectly affecting the environment. Although toxicity data are available for individual chemicals, generally there is no to...
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