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Jurnal Institusi
Aplikasi ekstrak daun tapak dara (Catharanthus roseus l.) terhadap pertumbuhan dan morfologi tanaman bawang daun (Allium fistulosum l.)
Jurnal Ilmiah Pertanian; Vol. 19 No. 1 (2022): Jurnal Ilmiah Pertanian; 29-37
Welsh onion (Allium fistulosum L.) is one of the horticultural commodity crops with high consumer value in Indonesia, but production remains low. Efforts to increase the production of Welsh onion can be performed by induction of anti-mitotic substanc...
PubMed
Caspase‐3 Activation Is Not Responsible for Vinblastine‐induced Bcl‐2 Phosphorylation and G2/M Arrest in Human Small Cell Lung Carcinoma Ms‐1 Cells
Jpn J Cancer Res
Vinblastine arrests cells in the G2/M phase of the cell cycle and subsequently induces cell death by apoptosis. We found that treatment of cells with vinblastine induced phosphorylation of Bcl‐2, resulting in the dissociation of Bcl‐2 and Bax. Mo...
PubMed
PDCT-05. FINAL RESULTS OF THE VINILO OPEN-LABEL PHASE II RANDOMIZED TRIAL FOR PEDIATRIC LOW-GRADE GLIOMAS (pLGG) COMPARING THE COMBINATION VINBLASTINE-NILOTINIB WITH VINBLASTINE ALONE
Neuro Oncol
Chemotherapy is the mainstay of non-surgical treatment in pLGG but many patients progress again after the end of the first treatment. Apart from the standard carboplatin-vincristine, new regimens with less toxicity are therefore desirable. Single age...
PubMed
RIP1/RIP3/MLKL-mediated necroptosis contributes to vinblastine-induced myocardial damage
Mol Cell Biochem
Vinblastine (VBL) has been considered as a first-line anti-tumor drug for many years. However, vinblastine-caused myocardial damage has been continually reported. The underlying molecular mechanism of the myocardial damage remains unknown. Here, we s...
PubMed
A Nonselective Cyclooxygenase Inhibitor Enhances the Activity of Vinblastine in a Naturally-Occurring Canine Model of Invasive Urothelial Carcinoma
Bladder Cancer
Background: Chemotherapy is expected to remain an important part of invasive urothelial carcinoma (UC) treatment. Strategies to enhance chemotherapy efficacy are needed. Objective: To determine the chemotherapy-enhancing effects of a nonselective cyc...
PubMed
Vinblastine treatment decreases the undifferentiated cell contamination of human iPSC-derived intestinal epithelial-like cells
Mol Ther Methods Clin Dev
Human induced pluripotent stem cell-derived intestinal epithelial cells (hiPSC-IECs) are expected to be utilized in regenerative medicine. To perform a safe transplantation without the risk of tumor formation, residual undifferentiated hiPSCs must be...
PubMed
Reversal of vinblastine transport by chlorpromazine in membrane vesicles from multidrug-resistant human CCRF-CEM leukaemia cells.
Br J Cancer
The mechanism of action of 2-chlorpromazine (2-chloro-10-(3-dimethylaminopropyl)-phenothiazine) as a reversal agent for P-glycoprotein-mediated multidrug resistance was investigated using inside out-orientated membrane vesicles prepared from vinblast...
PubMed
Potent Vinblastine C20′ Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line
ACS Med Chem Lett
[Image: see text] A series of disubstituted C20′-urea derivatives of vinblastine were prepared from 20′-aminovinblastine that was made accessible through a unique Fe(III)/NaBH(4)-mediated alkene functionalization reaction of anhydrovinblastine. T...
PubMed
Effects of vinblastine on noradrenergic axons
Br J Pharmacol
1 The effects of vinblastine and 6-hydroxydopamine (6-OHDA) on various parameters of adrenergic neurone functions in the rat were examined and compared. 2 During the first 12 h after injection of vinblastine, although the concentration of cardiac nor...
PubMed
Proteasomes are a target of the anti-tumour drug vinblastine.
Biochem J
Proteasomes, the proteolytic machinery of the ubiquitin/ATP-dependent pathway, have a relevant role in many processes crucial for cell physiology and cell cycle progression. Proteasome inhibitors are used to block cell cycle progression and to induce...
PubMed
The C terminus of β-tubulin regulates vinblastine-induced tubulin polymerization
Proc Natl Acad Sci U S A
Oligoanions such as sodium triphosphate or GTP prevent and/or reverse vinblastine-induced polymerization of tubulin. We now show that the anions of glutamate-rich extreme C termini of tubulin are similarly involved in the regulation of the vinblastin...
PubMed
Regulation of Bax by c-Jun NH(2)-terminal kinase and Bcl-xL in vinblastine-induced apoptosis
Biochem Pharmacol
Microtubule inhibitors, such as vinblastine, are widely used in cancer chemotherapy. Vinblastine exerts its antitumor effect by inducing apoptosis. In KB-3 cells, we have shown previously that vinblastine activates c-Jun NH(2)-terminal protein kinase...
PubMed
Radioimmunoassay of vinblastine and vincristine.
Br J Clin Pharmacol
1 The cytotoxic agent, vinblastine, was conjugated to albumin, using the Mannich reaction. Rabbits immunized with two conjugates, containing differing amounts of hapten, produce antibodies which bound [3H]-vinblastine. 2 Antisera from one rabbit cros...
PubMed
Preparation and Physicochemical Properties of Vinblastine Microparticles by Supercritical Antisolvent Process
Int J Mol Sci
The objective of the study was to prepare vinblastine microparticles by supercritical antisolvent process using N-methyl-2-pyrrolidone as solvent and carbon dioxide as antisolvent and evaluate its physicochemical properties. The effects of four proce...
PubMed
Long‐lasting Accumulation of Vinblastine in Inostamycin‐treated Multidrug‐resistant KB Cells
Jpn J Cancer Res
Inostamycin, a novel polyether compound, reverses multidrug resistance in KB cells. The mechanism of its action was studied by use of radioactively labeled vinblastine. Inostamycin dose‐dependently increased the accumulation of [(3)H] vinblastine i...
PubMed
Vinblastine sensitizes leukemia cells to cyclin-dependent kinase inhibitors, inducing acute cell cycle phase-independent apoptosis
Cancer Biol Ther
The efficacy of many chemotherapeutic agents can be attenuated by expression of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Mcl-1. Flavopiridol and dinaciclib are cyclin-dependent kinase 7 and 9 inhibitors that transcriptionally inhibit expressio...
PubMed
Vinblastine suppresses dynamics of individual microtubules in living interphase cells.
Mol Biol Cell
We have characterized the effects of vinblastine on the dynamic instability behavior of individual microtubules in living BS-C-1 cells microinjected with rhodamine-labeled tubulin and have found that at low concentrations (3-64 nM), vinblastine poten...
PubMed
Microtubules and pancreatic amylase release by mouse pancreas in vitro
J Cell Biol
The effects of vinblastine and colchicine on pancreatic acinar cells were studied by use of in vitro mouse pancreatic fragments. Vinblastine inhibited the release of amylase stimulated by bethanechol, caerulein, or ionophore A23187. Inhibition requir...
PubMed
Vinblastine induces acute, cell cycle phase-independent apoptosis in some leukemias and lymphomas and can induce acute apoptosis in others when Mcl-1 is suppressed
Mol Cancer Ther
Chemotherapeutic agents modify intracellular signaling that culminates in inhibition of Bcl-2 family members and initiates apoptosis. Inhibition of the Extracellular signal-Regulated Kinase by PD98059 dramatically accelerates vinblastine-mediated apo...
PubMed
Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein.
Br J Cancer
P-glycoprotein expression was demonstrated in two human intestinal adenocarcinoma cell-lines (HCT-8, ileocaecal and T84, colonic) by immunoprecipitation of a 170-180 kDa protein with monoclonal antibody JSB-1. Both HCT-8 and T84 formed functional epi...