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PubMed
PubMed
Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator mice
Mitochondrion
The mitochondrial DNA (mtDNA) polymerase γ (POLG) mutator mice provide the first experimental evidence that high levels of somatic mtDNA mutations can be functionally significant. Here we report that older homozygous, but not heterozygous, POLG mice...
PubMed
Low Bone Mass is Associated with Increased Carotid Intima Media Thickness in Men with Type 2 Diabetes Mellitus
Clin Med Insights Endocrinol Diabetes
Osteoporosis and atherosclerosis share common risk factors and the association of low bone mass with increased cardiovascular morbidity and mortality has been demonstrated in some studies. Nevertheless, most studies have been focused on women and onl...
PubMed
Recent Progress in Mouse Models for Tumor Suppressor Genes and its Implications in Human Cancer
Clin Med Insights Oncol
Gain-of-function mutations in oncogenes and loss-of-function mutations in tumor suppressor genes (TSG) lead to cancer. In most human cancers, these mutations occur in somatic tissues. However, hereditary forms of cancer exist for which individuals ar...
PubMed
Levonorgestrel-Releasing Intrauterine System and Iron Overload Syndrome
Clin Med Insights Case Rep
Severe fatigue is a common complaint among patients. This report presents a clinical case of a woman complaining of fatigue associated with diarrhea and myalgia that were first attributed to emotional stress and depression. Initially, the patient was...
PubMed
Corrigendum for “Acute Aortic Valve Rupture From Infective Endocarditis”
Clin Med Insights Case Rep
PubMed
PubMed
ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis
Br J Pharmacol
Recent advances have improved our understanding of the renin-angiotensin system (RAS). These have included the recognition that angiotensin (Ang)-(1-7) is a biologically active product of the RAS cascade. The identification of the ACE homologue ACE2,...
PubMed
HDL and endothelial protection
Br J Pharmacol
High-density lipoproteins (HDLs) represent a family of particles characterized by the presence of apolipoprotein A-I (apoA-I) and by their ability to transport cholesterol from peripheral tissues back to the liver. In addition to this function, HDLs ...
PubMed
VIP and PACAP: neuropeptide modulators of CNS inflammation, injury, and repair
Br J Pharmacol
Inflammatory processes play both regenerative and destructive roles in multiple sclerosis, stroke, CNS trauma, amyotrophic lateral sclerosis and aging-related neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's...
PubMed
PDE4 in the human heart – major player or little helper?
Br J Pharmacol
PDEs restrict the positive inotropic effects of β-adrenoceptor stimulation by degrading cAMP. Hence, PDE inhibitors sensitize the heart to catecholamines and are therefore used as positive inotropes. On the downside, this is accompanied by exaggerat...
PubMed
PDE3, but not PDE4, reduces β(1)- and β(2)-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients
Br J Pharmacol
BACKGROUND AND PURPOSE: PDE3 and/or PDE4 control ventricular effects of catecholamines in several species but their relative effects in failing human ventricle are unknown. We investigated whether the PDE3-selective inhibitor cilostamide (0.3–1 μM...
PubMed
Role and interactions of annexin A1 and oestrogens in the manifestation of sexual dimorphisms in cerebral and systemic inflammation
Br J Pharmacol
BACKGROUND AND PURPOSE: Gender differences in inflammation are well described, with females often showing more robust, oestrogen-associated responses. Here, we investigated the influence of gender, oestrogen and the anti-inflammatory protein annexin ...
PubMed
Rosuvastatin prevents angiotensin II-induced vascular changes by inhibition of NAD(P)H oxidase and COX-1
Br J Pharmacol
BACKGROUND AND PURPOSE: NAD(P)H oxidase and COX-1 participate in vascular damage induced by angiotensin II. We investigated the effect of rosuvastatin on endothelial dysfunction, vascular remodelling, changes in extracellular matrix components and me...
PubMed
In vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model
Br J Pharmacol
BACKGROUND AND PURPOSE: The α7 nicotinic ACh receptor subtype is abundantly expressed in the CNS and in the periphery. Recent evidence suggests that α7 nicotinic ACh receptor (nAChR) subtypes, which can be activated by an endogenous cholinergic ton...
PubMed
Effect of the TRPV1 antagonist SB-705498 on the nasal parasympathetic reflex response in the ovalbumin sensitized guinea pig
Br J Pharmacol
BACKGROUND AND PURPOSE: Nasal sensory nerves play an important role in symptoms associated with rhinitis triggered by environmental stimuli. Here, we propose that TRPV1 is pivotal in nasal sensory nerve activation and assess the potential of SB-70549...
PubMed
Glycogen synthase kinase-3 (GSK-3) regulates TGF-β(1)-induced differentiation of pulmonary fibroblasts
Br J Pharmacol
BACKGROUND: Chronic lung diseases such as asthma, COPD and pulmonary fibrosis are characterized by abnormal extracellular matrix (ECM) turnover. TGF-β is a key mediator stimulating ECM production by recruiting and activating lung fibroblasts and ini...
PubMed
Prostaglandin E(2)-induced intercellular adhesion molecule-1 expression is mediated by cAMP/Epac signalling modules in bEnd.3 brain endothelial cells
Br J Pharmacol
BACKGROUND AND PURPOSE: Prostaglandin E(2) (PGE(2)) has been implicated in the regulation of adhesion molecules, leukocyte adhesion and infiltration into inflamed site. However, the underlying mechanism therein involved remains ill-defined. In this s...
PubMed
Treatment with hydrogen sulfide alleviates streptozotocin-induced diabetic retinopathy in rats
Br J Pharmacol
BACKGROUND AND PURPOSE: Retinopathy, as a common complication of diabetes, is a leading cause of reduced visual acuity and acquired blindness in the adult population. The aim of present study was to investigate the therapeutic effect of hydrogen sulf...
PubMed
Preclinical evaluation of the abuse potential of Pitolisant, a histamine H(3) receptor inverse agonist/antagonist compared with Modafinil
Br J Pharmacol
BACKGROUND AND PURPOSE: Pitolisant, a histamine H(3) receptor inverse agonist/antagonist is currently under Phase III clinical trials for treatment of excessive daytime sleepiness namely in narcoleptic patients. Its drug abuse potential was investiga...