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PubMed
Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity
Biochem J
Recent work has demonstrated the importance of post-transcriptional gene regulation in toxic responses. In the present study, we used two rat models to investigate mRNA translation in the liver following xenobiotic-induced toxicity. By combining poly...
PubMed
Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies
Biochem J
Missense mutations in LRRK2 (leucine-rich repeat kinase 2) are a major cause of PD (Parkinson's disease). Several antibodies against LRRK2 have been developed, but results using these polyclonal antibodies have varied widely leading to conflicti...
PubMed
Doctors’ and nurses’ views on patient care for type 2 diabetes: an interview study in primary health care in Oman
Prim Health Care Res Dev
AIM: This study aimed at exploring the experiences of primary health-care providers of their encounters with patients with type 2 diabetes, and their preferences and suggestions for future improvement of diabetes care. BACKGROUND: Barriers to good di...
PubMed
Comment on “The Molecular Evolutionary Patterns of the Insulin/FOXO Signaling Pathway”
Evol Bioinform Online
Letter to the Editor on Wang M, Wang Q, Wang Z, Zhang X, Pan Y. The molecular evolutionary patterns of the insulin/FOXO signaling pathway. Evol Bioinform. 2013;9:1–16. doi: 10.4137/EBO.S10539.
PubMed
Nigerian Medical Students’ Opinions About Individuals Who Use and Abuse Psychoactive Substances
Subst Abuse
Substance use disorders are prevalent in Nigeria. The number of available specialist health providers is inadequate to fill the treatment gap. Interventions can be provided by nonspecialist health providers and have been found to be beneficial. Howev...
PubMed
Trace Amine Associated Receptor 1 Modulates Behavioral Effects of Ethanol
Subst Abuse
BACKGROUND: Few treatment options for alcohol use disorders (AUDs) exist and more are critically needed. Here, we assessed whether trace amine associated receptor 1 (TAAR1), a modulator of brain monoamine systems, is involved in the behavioral and re...
PubMed
Immunohaematological reference values for HIV-negative healthy adults in Botswana
Afr J Lab Med
BACKGROUND: Clinical laboratories in Botswana have relied entirely on the reference intervals for normal immunohaematological values provided by manufacturers’ kits and textbooks. OBJECTIVES: The aim of this study was to determine the means, median...
PubMed
The Great East Japan Earthquake Disaster: a Compilation of Published Literature on Health Needs and Relief Activities, March 2011-September 2012
PLoS Curr
Objective To provide an overview of the health needs following the Great East Japan Earthquake Disaster and the lessons identified. Methods The relevant of peer review and grey literature articles in English and Japanese, and books in Japanese, publi...
PubMed
Health Effects of Drought: a Systematic Review of the Evidence
PLoS Curr
Introduction. Climate change projections indicate that droughts will become more intense in the 21 century in some areas of the world. The El Niño Southern Oscillation is associated with drought in some countries, and forecasts can provide advance w...
PubMed
Which Anthropometric Indicators Identify a Pregnant Woman as Acutely Malnourished and Predict Adverse Birth Outcomes in the Humanitarian Context?
PLoS Curr
Currently there is no consensus on how to identify pregnant women as acutely malnourished and when to enroll them in nutritional programmes. Médecins Sans Frontières Switzerland undertook a literature review with the purpose of determining values o...
PubMed
Undiagnosed Genetic Muscle Disease in the North of England: an in Depth Phenotype Analysis
PLoS Curr
Advances in the molecular characterisation of genetic muscle disease has been rapid, as demonstrated by a recent analysis of these conditions in the north of England by Norwood et al (2009), in which a genetic diagnosis was achieved for 75.7% of pati...
PubMed
Social Factors as Modifiers of Hurricane Irene Evacuation Behavior in Beaufort County, NC
PLoS Curr
Encouraging residents in high-risk areas to evacuate before a hurricane makes landfall is one of the few ways to reduce hurricane-related morbidity and mortality. However, demographic factors associated with evacuation in at-risk groups have not been...
PubMed
Age-Dependent Germline Mosaicism of the Most Common Noonan Syndrome Mutation Shows the Signature of Germline Selection
Am J Hum Genet
Noonan syndrome (NS) is among the most common Mendelian genetic diseases (∼1/2,000 live births). Most cases (50%–84%) are sporadic, and new mutations are virtually always paternally derived. More than 47 different sites of NS de novo missense mut...
PubMed
PubMed
RNA interference targeting cathepsin B of the carcinogenic liver fluke, Opisthorchis viverrini
Parasitol Int
Functional genomics have not been reported for Opisthorchis viverrini or the related fish-borne fluke, Clonorchis sinensis. Here we describe the introduction by square wave electroporation of Cy3-labelled small RNA into adult O. viverrini worms. Adul...
PubMed
Can ‘Humanized’ Mice Improve Drug Development in the 21(st) Century?
Trends Pharmacol Sci
Chimeric mice, which have human hepatocytes engrafted in their liver, have been used to study human drug metabolism and pharmacodynamic responses for nearly 20 years. However, there are very few examples where their use has prospectively impacted the...
PubMed
Neuropsychological Performance and Family History in Children at Age 7 who Develop Adult Schizophrenia or Bipolar Psychosis in the New England Family Studies
Psychol Med
OBJECTIVE: Persons developing schizophrenia (SCZ) manifest various premorbid neuropsychological deficits, studied most often by measures of IQ. Far less is known about premorbid neuropsychological functioning in individuals who later develop bipolar ...
PubMed
DIFFERENCES IN THE DIAGNOSIS AND MANAGEMENT OF TYPE 2 DIABETES IN THREE COUNTRIES (US, UK AND GERMANY): RESULTS FROM A FACTORIAL EXPERIMENT
Med Care
OBJECTIVES: This paper examines the diagnosis and management of type-2 diabetes when exactly the same “patient” is encountered by 192 randomly selected primary care doctors in three different health care systems - the US, UK and Germany. METHODS:...
PubMed
Advanced periductal fibrosis from infection with the carcinogenic human liver fluke Opisthorchis viverrini correlates with elevated levels of IL-6
Hepatology
More than 750 million people are at risk of infection with food-borne liver flukes. Opisthorchis viverrini is considered among the most important of these parasites, due to its strong association with cholangiocarcinoma (CCA). O. viverrini infection ...
PubMed
Influences of organizational features of healthcare settings on clinical decision making: Qualitative results from a cross-national factorial experiment(*)
Health (London)
A proliferating literature documents cross-national variation in medical practice and seeks to explain observed differences in terms of the presence of certain kinds of healthcare systems, economic, and cultural differences between countries. Less is...