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PubMed
24 Weeks of Valganciclovir Prophylaxis in Children After Renal Transplantation: A 4-Year Experience
Transplantation
BACKGROUND: Cytomegalovirus (CMV) is the most common opportunistic infection after solid-organ transplant. Valganciclovir prophylaxis significantly reduces disease, but limited data are available on its use in children. Recently, an increase in delay...
PubMed
An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity
Medchemcomm
The recent discovery of a small-molecule benzosuberene-based phenol that demonstrates remarkable picomolar cytotoxicity against selected human cancer cell lines and strongly inhibits tubulin polymerization (1–2 µM) inspired the design and synthesi...
PubMed
Cardiac Risk is Not Associated with Hypertension Treatment Intensification
Am J Manag Care
OBJECTIVE: Considering cardiovascular (CV) risk could make clinical care more efficient and individualized, but most practice guidelines focus on single risk factors. We sought to see if hypertension treatment intensification (TI) is more likely in p...
PubMed
The Effects of the Fast Track Preventive Intervention on the Development of Conduct Disorder Across Childhood
Child Dev
The impact of the Fast Track intervention on externalizing disorders across childhood was examined. Eight hundred-ninety-one early-starting children (69% male; 51% African American) were randomly assigned by matched sets of schools to intervention or...
PubMed
Studies of Implicit Prototype Extraction In Patients with Mild Cognitive Impairment and Early Alzheimer’s Disease
J Exp Psychol Learn Mem Cogn
Studies of incidental category learning support the hypothesis of an implicit prototype-extraction system which is distinct from explicit memory (Smith, 2008). In those studies, patients with explicit-memory impairments due to damage to the medial-te...
PubMed
Argatroban Dose Reductions for Suspected Heparin-Induced Thrombocytopenia Complicated by Child-Pugh Class C Liver Disease
Ann Pharmacother
OBJECTIVE: To report our experience of reduced-dose argatroban in a patient with suspected heparin-induced thrombocytopenia (HIT) and Child-Pugh class C liver disease and review the relevant literature to summarize current recommendations on argatrob...
PubMed
The tumorigenic liver fluke Opisthorchis viverrini –multiple pathways to cancer
Trends Parasitol
Liver fluke infection caused by Opisthorchis viverrini is a major public health problem in Thailand and adjacent countries. In addition to infection-associated morbidity, infection with O. viverrini and the related Clonorchis sinensis are unarguable ...
PubMed
Research with rTMS in the treatment of aphasia
Restor Neurol Neurosci
This review of our research with rTMS to treat aphasia contains four parts: Part 1 reviews functional brain imaging studies related to recovery of language in aphasia with emphasis on nonfluent aphasia. Part 2 presents the rationale for using rTMS to...
PubMed
Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers: The Selenium and Vitamin E Cancer Prevention Trial (SELECT)
JAMA
CONTEXT: Secondary analyses of two randomized controlled trials (RCTs) and supportive epidemiologic and preclinical indicated the potential of selenium and vitamin E for preventing prostate cancer. OBJECTIVE: To determine whether selenium or vitamin ...
PubMed
Targeting Phosphodiesterases in Anti-platelet Therapy
Handb Exp Pharmacol
There are two primary modes of platelet inhibition: blockade of membrane receptors or neutralization of intracellular pathways. Both means of inhibition have proven benefits in the prevention and resolution of atherothrombotic events. With regard to ...
PubMed
Drug-Induced Thrombocytopenia for the Hospitalist Physician with a Focus on Heparin-lnduced Thrombocytopenia
Hosp Pract (1995)
Acute thrombocytopenia occurs commonly in hospitalized patients. For most, the etiology of an acutely declining platelet count is obvious and includes sepsis with disseminated intravascular coagulation, large-volume crystalloid infusion, or the admin...
PubMed
PubMed
PubMed
Excorporeal Normothermic Machine Perfusion Resuscitates Pig DCD Livers with Extended Warm Ischemia
J Surg Res
BACKGROUND: The shortage in donor livers has led to increased use of allografts derived from donation after cardiac death (DCD). The compromised viability in these livers leads to inferior post-transplantation allograft function and survival compared...
PubMed
Cellular therapy and bioartificial approaches to liver replacement
Curr Opin Organ Transplant
PURPOSE OF REVIEW: The success of liver transplantation has increased over the past 20 years due to improved immunosuppressive medications, surgical technique and donor-recipient selection. To date, the number of patients waiting for a liver transpla...
PubMed
Development of normative neuropsychological performance in Thailand for the assessment of HIV-associated neurocognitive disorders
J Clin Exp Neuropsychol
International studies of HIV-associated neurocognitive disorder (HAND) are needed to determine the viral and host factors associated with cognitive impairment particularly as more than 80% of HIV+ subjects reside in resource-limited settings. Recent ...
PubMed
Human-Scale Whole-Organ Bioengineering for Liver Transplantation: A Regenerative Medicine Approach
Cell Transplant
At this time, the only definitive treatment of hepatic failure is liver transplantation. However, transplantation has been limited by the severely limited supply of human donor livers. Alternatively, a regenerative medicine approach has been recently...
PubMed
Whole-organ re-engineering: a regenerative medicine approach in digestive surgery for organ replacement
Surg Today
Recovery from end-stage organ failure presents a challenge for the medical community, considering the limitations of extracorporeal assist devices and the shortage of donors when organ replacement is needed. There is a need for new methods to promote...
PubMed
Emerging Therapies in Castrate-Resistant Prostate Cancer
Curr Urol Rep
Prostate cancer is the most common cancer in men in the United States, and despite screening and early treatment, more than 27,000 men are predicted to die of the disease this year, almost all of whom will die of castrate-resistant, metastatic cancer...
PubMed
Identification of Microdeletions in Candidate Genes for Cleft Lip and/or Palate
Birth Defects Res A Clin Mol Teratol
BACKGROUND: Genome-wide association studies are now used routinely to identify genes implicated in complex traits. The panels used for such analyses can detect single nucleotide polymorphisms and copy number variants, both of which may help to identi...