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PubMed
Plasma Vitamin D and Biomarkers of Cardiometabolic Disease Risk in Adult Canadians, 2007–2009
Prev Chronic Dis
INTRODUCTION: Vitamin D may modulate cardiometabolic disease risk, although the relationship has not been investigated in the general Canadian population. Understanding this relationship may inform public health strategies to curb the incidence of ca...
PubMed
No Financial Disincentive for Choosing More Healthful Entrées on Children’s Menus in Full-Service Restaurants
Prev Chronic Dis
Children are eating restaurant foods more than ever before, and price is among the top considerations for food choices. We categorized and enumerated entrées on children’s menus from 75 full-service restaurant chains to compare prices of more heal...
PubMed
PubMed
Molecularly targeted approaches herald a new era of non-small-cell lung cancer treatment
Cancer Manag Res
The discovery of activating mutations in the epidermal growth-factor receptor (EGFR) gene in 2004 opened a new era of personalized treatment for non-small-cell lung cancer (NSCLC). EGFR mutations are associated with a high sensitivity to EGFR tyrosin...
PubMed
Inhaled anticholinergic use and all-cause mortality among elderly Medicare beneficiaries with chronic obstructive pulmonary disease
Int J Chron Obstruct Pulmon Dis
BACKGROUND: The purpose of this study was to examine the association between use of inhaled anticholinergics and all-cause mortality among elderly individuals with chronic obstructive pulmonary disease (COPD), after controlling for demographic, socio...
PubMed
Prognostic factors of tumor recurrence in completely resected non-small cell lung cancer
Cancer Manag Res
BACKGROUND: Patients with completely resected non-small cell lung cancer (NSCLC) have an excellent outcome; however tumor recurs in 30%–77% of patients. This study retrospectively analyzed the clinicopathologic features of patients with any operabl...
PubMed
Factors that Affect Integrity of Authorship of Scientific Meeting Abstracts
AJOB Prim Res
BACKGROUND: Strict criteria for manuscript authorship exist to guide decisions on who should be considered an author. Less is known about how authorship for scientific meetings is determined. Our goal was to explore factors that influence decisions a...
PubMed
The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation
Science
Eukaryotic cells can use the autophagy pathway to defend against microbes that gain access to the cytosol or reside in pathogen-modified vacuoles. It remains unclear if pathogens have evolved specific mechanisms to manipulate autophagy. Here we find ...
PubMed
Attitudes and beliefs about anti-retroviral therapy are associated with high risk sexual behaviors among the general population of Kisumu, Kenya
AIDS Care
Attitudes and beliefs about antiretroviral therapy (ART) may affect sexual risk behaviors among the general population in sub-Saharan Africa. We performed a cross-sectional population-based study in Kisumu, Kenya to test this hypothesis in October 20...
PubMed
Solutions for Determining the Significance Region Using the Johnson-Neyman Type Procedure in Generalized Linear (Mixed) Models
J Educ Behav Stat
Researchers often compare the relationship between an outcome and covariate for two or more groups by evaluating whether the fitted regression curves differ significantly. When they do, researchers need to determine the “significance region,” or ...
PubMed
Autophagy During Cardiac Stress: Joys and Frustrations of Autophagy
Annu Rev Physiol
The study of autophagy has been transformed by the cloning of most genes in the pathway and the introduction of GFP-LC3 as a reporter to allow visual assessment of autophagy. The field of cardiac biology is not alone in attempting to understand the i...
PubMed
Selective Class I HDAC Inhibition Suppresses Hypoxia-Induced Cardiopulmonary Remodeling Through an Anti-Proliferative Mechanism
Circ Res
RATIONALE: Histone deacetylase (HDAC) inhibitors are efficacious in models of hypertension-induced left ventricular (LV) heart failure. The consequences of HDAC inhibition in the context of pulmonary hypertension (PH) with associated right ventricula...
PubMed
Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA
Basic Res Cardiol
We have shown that the cellular process of macroautophagy plays a protective role in HL-1 cardiomyocytes subjected to simulated ischemia/reperfusion (sI/R) (Hamacher-Brady et al. in J Biol Chem 281(40):29776–29787). Since the nucleoside adenosine h...
PubMed
Practical Scoring System for the Identification of Patients with Intracerebral Hemorrhage at Highest Risk of Harboring an Underlying Vascular Etiology: The Secondary Intracerebral Hemorrhage Score
AJNR Am J Neuroradiol
BACKGROUND AND PURPOSE: An ICH patient's risk of harboring an underlying vascular etiology varies according to baseline clinical and NCCT characteristics. Our aim was to develop a practical scoring system to stratify patients with ICH according ...
PubMed
What Girls Won’t Do for Love: Human Immunodeficiency Virus/Sexually Transmitted Infections Risk Among Young African-American Women Driven by a Relationship Imperative
J Adolesc Health
PURPOSE: Rates of Human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs) continue to increase among African-American youth. Adolescents who have a stronger identity in relation to others (relational identity) rather than ...
PubMed
The alternative oxidase (AOX) gene in Vibrio fischeri is controlled by NsrR and upregulated in response to nitric oxide
Mol Microbiol
Alternative oxidase (AOX) is a respiratory oxidase found in certain eukaryotes and bacteria; however, its role in bacterial physiology is unclear. Exploiting the genetic tractability of the bacterium Vibrio fischeri, we explore the regulation of aox ...
PubMed
Gene Dosage-Dependent Effects of Cardiac-Specific Overexpression of the A(3) Adenosine Receptor
Circ Res
We used a genetic approach to determine whether increasing the level of A(3) adenosine receptors (A(3)ARs) expressed in the heart confers protection against ischemia without causing cardiac pathology. We generated mice carrying one (A(3)tg.1) or six ...
PubMed
Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors
Chem Commun (Camb)
A series of self-immolative boronic ester protected methyl salicylates and metal-binding groups with various linking strategies have been investigated for their use in the design of matrix metalloproteinase proinhibitors.
PubMed
Increased angiogenic factors during avascular retina prior to neovascularization in ROP model
Arch Ophthalmol
OBJECTIVE: To determine expressions of vascular endothelial growth factor (VEGF), pigment epithelial derived factor (PEDF) and respective receptors in retinas from a model of retinopathy of prematurity (ROP). METHOD: Retinas isolated from the 50/10 o...
PubMed
Review: Oxygen and trophoblast biology — A source of controversy
Placenta
Oxygen is necessary for life yet too much or too little oxygen is toxic to cells. The oxygen tension in the maternal plasma bathing placental villi is <20 mm Hg until 10–12 weeks’ gestation, rising to 40–80 mmHg and remaining in this range t...