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PubMed
Autophagy During Cardiac Stress: Joys and Frustrations of Autophagy
Annu Rev Physiol
The study of autophagy has been transformed by the cloning of most genes in the pathway and the introduction of GFP-LC3 as a reporter to allow visual assessment of autophagy. The field of cardiac biology is not alone in attempting to understand the i...
PubMed
Selective Class I HDAC Inhibition Suppresses Hypoxia-Induced Cardiopulmonary Remodeling Through an Anti-Proliferative Mechanism
Circ Res
RATIONALE: Histone deacetylase (HDAC) inhibitors are efficacious in models of hypertension-induced left ventricular (LV) heart failure. The consequences of HDAC inhibition in the context of pulmonary hypertension (PH) with associated right ventricula...
PubMed
Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA
Basic Res Cardiol
We have shown that the cellular process of macroautophagy plays a protective role in HL-1 cardiomyocytes subjected to simulated ischemia/reperfusion (sI/R) (Hamacher-Brady et al. in J Biol Chem 281(40):29776–29787). Since the nucleoside adenosine h...
PubMed
Practical Scoring System for the Identification of Patients with Intracerebral Hemorrhage at Highest Risk of Harboring an Underlying Vascular Etiology: The Secondary Intracerebral Hemorrhage Score
AJNR Am J Neuroradiol
BACKGROUND AND PURPOSE: An ICH patient's risk of harboring an underlying vascular etiology varies according to baseline clinical and NCCT characteristics. Our aim was to develop a practical scoring system to stratify patients with ICH according ...
PubMed
What Girls Won’t Do for Love: Human Immunodeficiency Virus/Sexually Transmitted Infections Risk Among Young African-American Women Driven by a Relationship Imperative
J Adolesc Health
PURPOSE: Rates of Human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs) continue to increase among African-American youth. Adolescents who have a stronger identity in relation to others (relational identity) rather than ...
PubMed
The alternative oxidase (AOX) gene in Vibrio fischeri is controlled by NsrR and upregulated in response to nitric oxide
Mol Microbiol
Alternative oxidase (AOX) is a respiratory oxidase found in certain eukaryotes and bacteria; however, its role in bacterial physiology is unclear. Exploiting the genetic tractability of the bacterium Vibrio fischeri, we explore the regulation of aox ...
PubMed
Gene Dosage-Dependent Effects of Cardiac-Specific Overexpression of the A(3) Adenosine Receptor
Circ Res
We used a genetic approach to determine whether increasing the level of A(3) adenosine receptors (A(3)ARs) expressed in the heart confers protection against ischemia without causing cardiac pathology. We generated mice carrying one (A(3)tg.1) or six ...
PubMed
Investigation of self-immolative linkers in the design of hydrogen peroxide activated metalloprotein inhibitors
Chem Commun (Camb)
A series of self-immolative boronic ester protected methyl salicylates and metal-binding groups with various linking strategies have been investigated for their use in the design of matrix metalloproteinase proinhibitors.
PubMed
Increased angiogenic factors during avascular retina prior to neovascularization in ROP model
Arch Ophthalmol
OBJECTIVE: To determine expressions of vascular endothelial growth factor (VEGF), pigment epithelial derived factor (PEDF) and respective receptors in retinas from a model of retinopathy of prematurity (ROP). METHOD: Retinas isolated from the 50/10 o...
PubMed
Review: Oxygen and trophoblast biology — A source of controversy
Placenta
Oxygen is necessary for life yet too much or too little oxygen is toxic to cells. The oxygen tension in the maternal plasma bathing placental villi is <20 mm Hg until 10–12 weeks’ gestation, rising to 40–80 mmHg and remaining in this range t...
PubMed
Heritability of Respiratory Infection with Pseudomonas aeruginosa in Cystic Fibrosis
J Pediatr
OBJECTIVE: To quantify the relative contribution of factors other than cystic fibrosis transmembrane conductance regulator genotype and environment on the acquisition of Pseudomonas aeruginosa (Pa) by patients with cystic fibrosis. STUDY DESIGN: Lung...
PubMed
Placental Dysfunction and Fetal Programming: The Importance of Placental Size, Shape, Histopathology, and Molecular Composition
Semin Reprod Med
Normal function of the placenta is pivotal for optimal fetal growth and development. Fetal programming commonly is associated with placental dysfunction that predisposes to obstetric complications and .suboptimal fetal outcomes. We consider several c...
PubMed
The genetic landscape of high-risk neuroblastoma
Nat Genet
Neuroblastoma is a malignancy of the developing sympathetic nervous system that often presents with widespread metastatic disease, resulting in survival rates of less than 50%(1). To determine the spectrum of somatic mutation in high-risk neuroblasto...
PubMed
Prevalence of alcohol use disorders before and after bariatric surgery
JAMA
CONTEXT: Anecdotal reports suggest bariatric surgery may increase the risk of alcohol use disorders (AUD), but prospective data are lacking. OBJECTIVES: Determine the prevalence of pre- and postoperative AUD, and independent predictors of postoperati...
PubMed
A phase III study of anti-B4-blocked ricin as adjuvant therapy post-autologous bone marrow transplant: CALGB 9254
Leuk Lymphoma
Anti-B4-blocked ricin (anti-B4-bR) is a potent immunotoxin directed against the CD 19 antigen. Previous phase I and II studies suggested a possible role for anti-B4-bR as consolidation after high-dose chemotherapy and autologous stem cell transplant....
PubMed
Supplemental Oxygen can Cause Intravitreous Neovascularization through JAK/STAT Pathways in a Model of Retinopathy of Prematurity
Invest Ophthalmol Vis Sci
PURPOSE: To investigate whether oxygen stresses experienced in retinopathy of prematurity (ROP) would trigger signaling through reactive oxygen species (ROS) and the Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathways to...
PubMed
NOCICEPTIVE AND NEUROPATHIC PAIN IN PATIENTS WITH LUNG CANCER: A COMPARISON OF PAIN QUALITY DESCRIPTORS
J Pain Symptom Manage
Predictive validity of each word from the McGill Pain Questionnaire (MPQ) has not been investigated independent of pain etiology. The purpose of this study was to explore differences in the words used to describe nociceptive and neuropathic pain. Pat...
PubMed
Thyroid Dose Estimates for a Cohort of Belarusian Children Exposed to Radiation from the Chernobyl Accident
Radiat Res
The U.S. National Cancer Institute, in collaboration with the Belarusian Ministry of Health, is conducting a study of thyroid cancer and other thyroid diseases in a cohort of about 12,000 persons who were exposed to fallout from the Chernobyl acciden...
PubMed
The DRD4 Exon III VNTR, Bupropion, and Associations With Prospective Abstinence
Nicotine Tob Res
INTRODUCTION: DRD4 Exon III Variable Number of Tandem Repeat (VNTR) variation was found to interact with bupropion to influence prospective smoking abstinence, in a recently published longitudinal analyses of N = 331 individuals from a randomized dou...
PubMed
Levels of (S)-N′-Nitrosonornicotine in U.S. Tobacco Products
Nicotine Tob Res
INTRODUCTION: N′-nitrosonornicotine (NNN), an esophageal and oral carcinogen present in tobacco products, has a chiral center in its structure. Of its two enantiomers, (S)-NNN exhibits higher tumorigenic potency than (R)-NNN. There is no informatio...