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PubMed
Heritability of Respiratory Infection with Pseudomonas aeruginosa in Cystic Fibrosis
J Pediatr
OBJECTIVE: To quantify the relative contribution of factors other than cystic fibrosis transmembrane conductance regulator genotype and environment on the acquisition of Pseudomonas aeruginosa (Pa) by patients with cystic fibrosis. STUDY DESIGN: Lung...
PubMed
Placental Dysfunction and Fetal Programming: The Importance of Placental Size, Shape, Histopathology, and Molecular Composition
Semin Reprod Med
Normal function of the placenta is pivotal for optimal fetal growth and development. Fetal programming commonly is associated with placental dysfunction that predisposes to obstetric complications and .suboptimal fetal outcomes. We consider several c...
PubMed
The genetic landscape of high-risk neuroblastoma
Nat Genet
Neuroblastoma is a malignancy of the developing sympathetic nervous system that often presents with widespread metastatic disease, resulting in survival rates of less than 50%(1). To determine the spectrum of somatic mutation in high-risk neuroblasto...
PubMed
Prevalence of alcohol use disorders before and after bariatric surgery
JAMA
CONTEXT: Anecdotal reports suggest bariatric surgery may increase the risk of alcohol use disorders (AUD), but prospective data are lacking. OBJECTIVES: Determine the prevalence of pre- and postoperative AUD, and independent predictors of postoperati...
PubMed
A phase III study of anti-B4-blocked ricin as adjuvant therapy post-autologous bone marrow transplant: CALGB 9254
Leuk Lymphoma
Anti-B4-blocked ricin (anti-B4-bR) is a potent immunotoxin directed against the CD 19 antigen. Previous phase I and II studies suggested a possible role for anti-B4-bR as consolidation after high-dose chemotherapy and autologous stem cell transplant....
PubMed
Supplemental Oxygen can Cause Intravitreous Neovascularization through JAK/STAT Pathways in a Model of Retinopathy of Prematurity
Invest Ophthalmol Vis Sci
PURPOSE: To investigate whether oxygen stresses experienced in retinopathy of prematurity (ROP) would trigger signaling through reactive oxygen species (ROS) and the Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathways to...
PubMed
NOCICEPTIVE AND NEUROPATHIC PAIN IN PATIENTS WITH LUNG CANCER: A COMPARISON OF PAIN QUALITY DESCRIPTORS
J Pain Symptom Manage
Predictive validity of each word from the McGill Pain Questionnaire (MPQ) has not been investigated independent of pain etiology. The purpose of this study was to explore differences in the words used to describe nociceptive and neuropathic pain. Pat...
PubMed
Thyroid Dose Estimates for a Cohort of Belarusian Children Exposed to Radiation from the Chernobyl Accident
Radiat Res
The U.S. National Cancer Institute, in collaboration with the Belarusian Ministry of Health, is conducting a study of thyroid cancer and other thyroid diseases in a cohort of about 12,000 persons who were exposed to fallout from the Chernobyl acciden...
PubMed
The DRD4 Exon III VNTR, Bupropion, and Associations With Prospective Abstinence
Nicotine Tob Res
INTRODUCTION: DRD4 Exon III Variable Number of Tandem Repeat (VNTR) variation was found to interact with bupropion to influence prospective smoking abstinence, in a recently published longitudinal analyses of N = 331 individuals from a randomized dou...
PubMed
Levels of (S)-N′-Nitrosonornicotine in U.S. Tobacco Products
Nicotine Tob Res
INTRODUCTION: N′-nitrosonornicotine (NNN), an esophageal and oral carcinogen present in tobacco products, has a chiral center in its structure. Of its two enantiomers, (S)-NNN exhibits higher tumorigenic potency than (R)-NNN. There is no informatio...
PubMed
Smoking, Menthol Cigarettes, and Peripheral Artery Disease in U.S. Adults
Nicotine Tob Res
INTRODUCTION: Cigarette flavorings, with the exception of menthol, have been banned in the United States under the Family Smoking Prevention and Tobacco Control Act. Given the large number of menthol cigarette smokers in the United States, we investi...
PubMed
Transitions in Smoking Status Over Time in a Population-Based Panel Study of Smokers
Nicotine Tob Res
INTRODUCTION: Few studies have examined the transitions of smokers in the general population through multiple periods of daily, occasional smoking, or abstinence over time. Transitions from daily to occasional smoking are particularly of interest as ...
PubMed
Nicotine Delivery to Rats via Lung Alveolar Region-Targeted Aerosol Technology Produces Blood Pharmacokinetics Resembling Human Smoking
Nicotine Tob Res
INTRODUCTION: Nicotine is a heavily used addictive drug acquired through smoking tobacco. Nicotine in cigarette smoke is deposited and absorbed in the lungs, which results in a rapidly peaked slowly declining arterial concentration. This pattern play...
PubMed
Subjective Responses to Oral Tobacco Products: Scale Validation
Nicotine Tob Res
INTRODUCTION: Several noncombusted oral tobacco products have been introduced that are primarily marketed to cigarette smokers. An important component of evaluating these products involves assessment of subjective responses to the product. To date, f...
PubMed
A Systematic Review of the Relationships Between Craving and Smoking Cessation
Nicotine Tob Res
INTRODUCTION: Craving is often portrayed as a defining feature of addiction, but the role of craving in the addictive process is controversial. Particularly contentious is the extent to which drug craving predicts subsequent relapse. METHODS: This re...
PubMed
Race, Gender, and Nicotine Metabolism in Adolescent Smokers
Nicotine Tob Res
INTRODUCTION: Differences in the rate of nicotine metabolism between genders and different races have been hypothesized to contribute to disparities in smoking rate, susceptibility to addiction, and ability to quit smoking. The purpose of this study ...
PubMed
A Comparison of Cigarette Smoking Profiles in Opioid-Dependent Pregnant Patients Receiving Methadone or Buprenorphine
Nicotine Tob Res
INTRODUCTION: Little is known about the relationship between cigarette smoking and agonist treatment in opioid-dependent pregnant patients. The objective of this study is to examine the extent to which cigarette smoking profiles differentially change...
PubMed
Pain sensitivity and pericranial tenderness in children with tension-type headache: a controlled study
J Pain Res
PURPOSE: To compare tenderness and pain sensitivity in children (aged 7–17 years) with tension-type headache (TTH) and healthy controls using total tenderness score (TTS), pressure pain threshold (PPT), and pain perceived at suprapressure pain thre...
PubMed
Association of body mass index with some fertility markers among male partners of infertile couples
Int J Gen Med
BACKGROUND: The available evidence on the role of obesity and body mass index (BMI) on male infertility has been controversial or inconclusive to some extent. OBJECTIVES: The aim of this study was to investigate the role of BMI on some male-fertility...
PubMed
Chronic rhinosinusitis and emerging treatment options
Int J Gen Med
This review describes the epidemiology and various treatments in chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Evidence for short-term use of systemic corticosteroids has been shown to be favorable in ...