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PubMed
Insights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin
Br J Pharmacol
BACKGROUND AND PURPOSE: Blood-stage Plasmodium parasites cause morbidity and mortality from malaria. Parasite resistance to drugs makes development of new chemotherapies an urgency. Aminoacyl-tRNA synthetases have been validated as antimalarial drug ...
PubMed
Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite
Br J Pharmacol
BACKGROUND AND PURPOSE: Nitrite (NO(2)(−)) has recently been shown to represent a potential source of NO, in particular under hypoxic conditions. The aim of the current study was to compare the haemodynamic effects of NO(2)(−) in healthy voluntee...
PubMed
Systemic bile acid sensing by G protein-coupled bile acid receptor 1 (GPBAR1) promotes PYY and GLP-1 release
Br J Pharmacol
BACKGROUND AND PURPOSE: Nutrient sensing in the gut is believed to be accomplished through activation of GPCRs expressed on enteroendocrine cells. In particular, L-cells located predominantly in distal regions of the gut secrete glucagon-like peptide...
PubMed
Effect of low doses of cannabidiolic acid and ondansetron on LiCl-induced conditioned gaping (a model of nausea-induced behaviour) in rats
Br J Pharmacol
BACKGROUND AND PURPOSE: To determine the minimally effective dose of cannabidiolic acid (CBDA) that effectively reduces lithium chloride (LiCl)-induced conditioned gaping reactions (nausea-induced behaviour) in rats and to determine if these low syst...
PubMed
Arginase inhibition alleviates hypertension in the metabolic syndrome
Br J Pharmacol
BACKGROUND AND PURPOSE: We have previously shown that arginase inhibition alleviates hypertension associated with in a diabetic animal model. Here, we investigated the protective effect of arginase inhibition on hypertension in metabolic syndrome. EX...
PubMed
Effects of the antianginal drug, ranolazine, on the brain sodium channel Na(V)1.2 and its modulation by extracellular protons
Br J Pharmacol
BACKGROUND AND PURPOSE: Ranolazine is an antianginal drug currently approved for treatment of angina pectoris in the United States. Recent studies have focused on its effects on neuronal channels and its possible therapeutic uses in the nervous syste...
PubMed
PubMed
A celebration of mechanics: from nano to macro. The J. Michael T. Thompson Festschrift issue
Philos Trans A Math Phys Eng Sci
This Theme Issue is dedicated to the topic ‘Mechanics: from nano to macro’ and marks the 75th birthday of Dr J. Michael T. Thompson, Fellow of the Royal Society, whose current affiliations are as follows: (i) Honorary Fellow, Department of Applie...
PubMed
The interaction of hydrogen with the {010} surfaces of Mg and Fe olivine as models for interstellar dust grains: a density functional theory study
Philos Trans A Math Phys Eng Sci
There is no consensus as yet to account for the significant presence of water on the terrestrial planets, but suggested sources include direct hydrogen adsorption from the parent molecular cloud after the planets’ formation, and delivery of hydrous...
PubMed
PubMed
Tipping points in open systems: bifurcation, noise-included and rate-dependent examples in the climate system
Philos Trans A Math Phys Eng Sci
PubMed
Alterations to the remote control of Shh gene expression cause congenital abnormalities
Philos Trans R Soc Lond B Biol Sci
Multi-species conserved non-coding elements occur in the vertebrate genome and are clustered in the vicinity of developmentally regulated genes. Many are known to act as cis-regulators of transcription and may reside at long distances from the genes ...
PubMed
From remote enhancers to gene regulation: charting the genome's regulatory landscapes
Philos Trans R Soc Lond B Biol Sci
Vertebrate genes are characterized by the presence of cis-regulatory elements located at great distances from the genes they control. Alterations of these elements have been implicated in human diseases and evolution, yet little is known about how th...
PubMed
Functional anatomy of distant-acting mammalian enhancers
Philos Trans R Soc Lond B Biol Sci
Transcriptional enhancers are a major class of functional element embedded in the vast non-coding portion of the human genome. Acting over large genomic distances, enhancers play critical roles in the tissue and cell type-specific regulation of genes...
PubMed
Human genetic variation within neural crest enhancers: molecular and phenotypic implications
Philos Trans R Soc Lond B Biol Sci
Developmental gene expression programmes are coordinated by the specialized distal cis-regulatory elements called enhancers, which integrate lineage- and signalling-dependent inputs to guide morphogenesis. In previous work, we characterized the genom...
PubMed
High-resolution analysis of cis-acting regulatory networks at the α-globin locus
Philos Trans R Soc Lond B Biol Sci
We have combined the circular chromosome conformation capture protocol with high-throughput, genome-wide sequence analysis to characterize the cis-acting regulatory network at a single locus. In contrast to methods which identify large interacting re...
PubMed
Expression quantitative trait loci: present and future
Philos Trans R Soc Lond B Biol Sci
The last few years have seen the development of large efforts for the analysis of genome function, especially in the context of genome variation. One of the most prominent directions has been the extensive set of studies on expression quantitative tr...
PubMed
Deconvoluting complex tissues for expression quantitative trait locus-based analyses
Philos Trans R Soc Lond B Biol Sci
Breast cancer genome-wide association studies have pinpointed dozens of variants associated with breast cancer pathogenesis. The majority of risk variants, however, are located outside of known protein-coding regions. Therefore, identifying which gen...
PubMed
Effects of gene regulatory reprogramming on gene expression in human and mouse developing hearts
Philos Trans R Soc Lond B Biol Sci
Lineage-specific regulatory elements underlie adaptation of species and play a role in disease susceptibility. We compared functionally conserved and lineage-specific enhancers by cross-mapping 5042 human and 6564 mouse heart enhancers. Of these, 79 ...
PubMed
Chromatin organization and global regulation of Hox gene clusters
Philos Trans R Soc Lond B Biol Sci
During development, a properly coordinated expression of Hox genes, within their different genomic clusters is critical for patterning the body plans of many animals with a bilateral symmetry. The fascinating correspondence between the topological or...