25,201,077 dokumen ditemukan
(Menampilkan 901-920 | Halaman 46 dari 1260054)
Urutkan
#
Judul
Penulis
Tahun
Akses
PubMed
PDE4 in the human heart – major player or little helper?
Br J Pharmacol
PDEs restrict the positive inotropic effects of β-adrenoceptor stimulation by degrading cAMP. Hence, PDE inhibitors sensitize the heart to catecholamines and are therefore used as positive inotropes. On the downside, this is accompanied by exaggerat...
PubMed
PDE3, but not PDE4, reduces β(1)- and β(2)-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients
Br J Pharmacol
BACKGROUND AND PURPOSE: PDE3 and/or PDE4 control ventricular effects of catecholamines in several species but their relative effects in failing human ventricle are unknown. We investigated whether the PDE3-selective inhibitor cilostamide (0.3–1 μM...
PubMed
Role and interactions of annexin A1 and oestrogens in the manifestation of sexual dimorphisms in cerebral and systemic inflammation
Br J Pharmacol
BACKGROUND AND PURPOSE: Gender differences in inflammation are well described, with females often showing more robust, oestrogen-associated responses. Here, we investigated the influence of gender, oestrogen and the anti-inflammatory protein annexin ...
PubMed
Rosuvastatin prevents angiotensin II-induced vascular changes by inhibition of NAD(P)H oxidase and COX-1
Br J Pharmacol
BACKGROUND AND PURPOSE: NAD(P)H oxidase and COX-1 participate in vascular damage induced by angiotensin II. We investigated the effect of rosuvastatin on endothelial dysfunction, vascular remodelling, changes in extracellular matrix components and me...
PubMed
In vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model
Br J Pharmacol
BACKGROUND AND PURPOSE: The α7 nicotinic ACh receptor subtype is abundantly expressed in the CNS and in the periphery. Recent evidence suggests that α7 nicotinic ACh receptor (nAChR) subtypes, which can be activated by an endogenous cholinergic ton...
PubMed
Effect of the TRPV1 antagonist SB-705498 on the nasal parasympathetic reflex response in the ovalbumin sensitized guinea pig
Br J Pharmacol
BACKGROUND AND PURPOSE: Nasal sensory nerves play an important role in symptoms associated with rhinitis triggered by environmental stimuli. Here, we propose that TRPV1 is pivotal in nasal sensory nerve activation and assess the potential of SB-70549...
PubMed
Glycogen synthase kinase-3 (GSK-3) regulates TGF-β(1)-induced differentiation of pulmonary fibroblasts
Br J Pharmacol
BACKGROUND: Chronic lung diseases such as asthma, COPD and pulmonary fibrosis are characterized by abnormal extracellular matrix (ECM) turnover. TGF-β is a key mediator stimulating ECM production by recruiting and activating lung fibroblasts and ini...
PubMed
Prostaglandin E(2)-induced intercellular adhesion molecule-1 expression is mediated by cAMP/Epac signalling modules in bEnd.3 brain endothelial cells
Br J Pharmacol
BACKGROUND AND PURPOSE: Prostaglandin E(2) (PGE(2)) has been implicated in the regulation of adhesion molecules, leukocyte adhesion and infiltration into inflamed site. However, the underlying mechanism therein involved remains ill-defined. In this s...
PubMed
Treatment with hydrogen sulfide alleviates streptozotocin-induced diabetic retinopathy in rats
Br J Pharmacol
BACKGROUND AND PURPOSE: Retinopathy, as a common complication of diabetes, is a leading cause of reduced visual acuity and acquired blindness in the adult population. The aim of present study was to investigate the therapeutic effect of hydrogen sulf...
PubMed
Preclinical evaluation of the abuse potential of Pitolisant, a histamine H(3) receptor inverse agonist/antagonist compared with Modafinil
Br J Pharmacol
BACKGROUND AND PURPOSE: Pitolisant, a histamine H(3) receptor inverse agonist/antagonist is currently under Phase III clinical trials for treatment of excessive daytime sleepiness namely in narcoleptic patients. Its drug abuse potential was investiga...
PubMed
Insights into the preclinical treatment of blood-stage malaria by the antibiotic borrelidin
Br J Pharmacol
BACKGROUND AND PURPOSE: Blood-stage Plasmodium parasites cause morbidity and mortality from malaria. Parasite resistance to drugs makes development of new chemotherapies an urgency. Aminoacyl-tRNA synthetases have been validated as antimalarial drug ...
PubMed
Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite
Br J Pharmacol
BACKGROUND AND PURPOSE: Nitrite (NO(2)(−)) has recently been shown to represent a potential source of NO, in particular under hypoxic conditions. The aim of the current study was to compare the haemodynamic effects of NO(2)(−) in healthy voluntee...
PubMed
Systemic bile acid sensing by G protein-coupled bile acid receptor 1 (GPBAR1) promotes PYY and GLP-1 release
Br J Pharmacol
BACKGROUND AND PURPOSE: Nutrient sensing in the gut is believed to be accomplished through activation of GPCRs expressed on enteroendocrine cells. In particular, L-cells located predominantly in distal regions of the gut secrete glucagon-like peptide...
PubMed
Effect of low doses of cannabidiolic acid and ondansetron on LiCl-induced conditioned gaping (a model of nausea-induced behaviour) in rats
Br J Pharmacol
BACKGROUND AND PURPOSE: To determine the minimally effective dose of cannabidiolic acid (CBDA) that effectively reduces lithium chloride (LiCl)-induced conditioned gaping reactions (nausea-induced behaviour) in rats and to determine if these low syst...
PubMed
Arginase inhibition alleviates hypertension in the metabolic syndrome
Br J Pharmacol
BACKGROUND AND PURPOSE: We have previously shown that arginase inhibition alleviates hypertension associated with in a diabetic animal model. Here, we investigated the protective effect of arginase inhibition on hypertension in metabolic syndrome. EX...
PubMed
Effects of the antianginal drug, ranolazine, on the brain sodium channel Na(V)1.2 and its modulation by extracellular protons
Br J Pharmacol
BACKGROUND AND PURPOSE: Ranolazine is an antianginal drug currently approved for treatment of angina pectoris in the United States. Recent studies have focused on its effects on neuronal channels and its possible therapeutic uses in the nervous syste...
PubMed
PubMed
A celebration of mechanics: from nano to macro. The J. Michael T. Thompson Festschrift issue
Philos Trans A Math Phys Eng Sci
This Theme Issue is dedicated to the topic ‘Mechanics: from nano to macro’ and marks the 75th birthday of Dr J. Michael T. Thompson, Fellow of the Royal Society, whose current affiliations are as follows: (i) Honorary Fellow, Department of Applie...
PubMed
The interaction of hydrogen with the {010} surfaces of Mg and Fe olivine as models for interstellar dust grains: a density functional theory study
Philos Trans A Math Phys Eng Sci
There is no consensus as yet to account for the significant presence of water on the terrestrial planets, but suggested sources include direct hydrogen adsorption from the parent molecular cloud after the planets’ formation, and delivery of hydrous...
PubMed