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PubMed
Undiagnosed Genetic Muscle Disease in the North of England: an in Depth Phenotype Analysis
PLoS Curr
Advances in the molecular characterisation of genetic muscle disease has been rapid, as demonstrated by a recent analysis of these conditions in the north of England by Norwood et al (2009), in which a genetic diagnosis was achieved for 75.7% of pati...
PubMed
Social Factors as Modifiers of Hurricane Irene Evacuation Behavior in Beaufort County, NC
PLoS Curr
Encouraging residents in high-risk areas to evacuate before a hurricane makes landfall is one of the few ways to reduce hurricane-related morbidity and mortality. However, demographic factors associated with evacuation in at-risk groups have not been...
PubMed
Age-Dependent Germline Mosaicism of the Most Common Noonan Syndrome Mutation Shows the Signature of Germline Selection
Am J Hum Genet
Noonan syndrome (NS) is among the most common Mendelian genetic diseases (∼1/2,000 live births). Most cases (50%–84%) are sporadic, and new mutations are virtually always paternally derived. More than 47 different sites of NS de novo missense mut...
PubMed
PubMed
RNA interference targeting cathepsin B of the carcinogenic liver fluke, Opisthorchis viverrini
Parasitol Int
Functional genomics have not been reported for Opisthorchis viverrini or the related fish-borne fluke, Clonorchis sinensis. Here we describe the introduction by square wave electroporation of Cy3-labelled small RNA into adult O. viverrini worms. Adul...
PubMed
Can ‘Humanized’ Mice Improve Drug Development in the 21(st) Century?
Trends Pharmacol Sci
Chimeric mice, which have human hepatocytes engrafted in their liver, have been used to study human drug metabolism and pharmacodynamic responses for nearly 20 years. However, there are very few examples where their use has prospectively impacted the...
PubMed
Neuropsychological Performance and Family History in Children at Age 7 who Develop Adult Schizophrenia or Bipolar Psychosis in the New England Family Studies
Psychol Med
OBJECTIVE: Persons developing schizophrenia (SCZ) manifest various premorbid neuropsychological deficits, studied most often by measures of IQ. Far less is known about premorbid neuropsychological functioning in individuals who later develop bipolar ...
PubMed
DIFFERENCES IN THE DIAGNOSIS AND MANAGEMENT OF TYPE 2 DIABETES IN THREE COUNTRIES (US, UK AND GERMANY): RESULTS FROM A FACTORIAL EXPERIMENT
Med Care
OBJECTIVES: This paper examines the diagnosis and management of type-2 diabetes when exactly the same “patient” is encountered by 192 randomly selected primary care doctors in three different health care systems - the US, UK and Germany. METHODS:...
PubMed
Advanced periductal fibrosis from infection with the carcinogenic human liver fluke Opisthorchis viverrini correlates with elevated levels of IL-6
Hepatology
More than 750 million people are at risk of infection with food-borne liver flukes. Opisthorchis viverrini is considered among the most important of these parasites, due to its strong association with cholangiocarcinoma (CCA). O. viverrini infection ...
PubMed
Influences of organizational features of healthcare settings on clinical decision making: Qualitative results from a cross-national factorial experiment(*)
Health (London)
A proliferating literature documents cross-national variation in medical practice and seeks to explain observed differences in terms of the presence of certain kinds of healthcare systems, economic, and cultural differences between countries. Less is...
PubMed
24 Weeks of Valganciclovir Prophylaxis in Children After Renal Transplantation: A 4-Year Experience
Transplantation
BACKGROUND: Cytomegalovirus (CMV) is the most common opportunistic infection after solid-organ transplant. Valganciclovir prophylaxis significantly reduces disease, but limited data are available on its use in children. Recently, an increase in delay...
PubMed
An Amino-Benzosuberene Analogue That Inhibits Tubulin Assembly and Demonstrates Remarkable Cytotoxicity
Medchemcomm
The recent discovery of a small-molecule benzosuberene-based phenol that demonstrates remarkable picomolar cytotoxicity against selected human cancer cell lines and strongly inhibits tubulin polymerization (1–2 µM) inspired the design and synthesi...
PubMed
Cardiac Risk is Not Associated with Hypertension Treatment Intensification
Am J Manag Care
OBJECTIVE: Considering cardiovascular (CV) risk could make clinical care more efficient and individualized, but most practice guidelines focus on single risk factors. We sought to see if hypertension treatment intensification (TI) is more likely in p...
PubMed
The Effects of the Fast Track Preventive Intervention on the Development of Conduct Disorder Across Childhood
Child Dev
The impact of the Fast Track intervention on externalizing disorders across childhood was examined. Eight hundred-ninety-one early-starting children (69% male; 51% African American) were randomly assigned by matched sets of schools to intervention or...
PubMed
Studies of Implicit Prototype Extraction In Patients with Mild Cognitive Impairment and Early Alzheimer’s Disease
J Exp Psychol Learn Mem Cogn
Studies of incidental category learning support the hypothesis of an implicit prototype-extraction system which is distinct from explicit memory (Smith, 2008). In those studies, patients with explicit-memory impairments due to damage to the medial-te...
PubMed
Argatroban Dose Reductions for Suspected Heparin-Induced Thrombocytopenia Complicated by Child-Pugh Class C Liver Disease
Ann Pharmacother
OBJECTIVE: To report our experience of reduced-dose argatroban in a patient with suspected heparin-induced thrombocytopenia (HIT) and Child-Pugh class C liver disease and review the relevant literature to summarize current recommendations on argatrob...
PubMed
The tumorigenic liver fluke Opisthorchis viverrini –multiple pathways to cancer
Trends Parasitol
Liver fluke infection caused by Opisthorchis viverrini is a major public health problem in Thailand and adjacent countries. In addition to infection-associated morbidity, infection with O. viverrini and the related Clonorchis sinensis are unarguable ...
PubMed
Research with rTMS in the treatment of aphasia
Restor Neurol Neurosci
This review of our research with rTMS to treat aphasia contains four parts: Part 1 reviews functional brain imaging studies related to recovery of language in aphasia with emphasis on nonfluent aphasia. Part 2 presents the rationale for using rTMS to...
PubMed
Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers: The Selenium and Vitamin E Cancer Prevention Trial (SELECT)
JAMA
CONTEXT: Secondary analyses of two randomized controlled trials (RCTs) and supportive epidemiologic and preclinical indicated the potential of selenium and vitamin E for preventing prostate cancer. OBJECTIVE: To determine whether selenium or vitamin ...
PubMed
Targeting Phosphodiesterases in Anti-platelet Therapy
Handb Exp Pharmacol
There are two primary modes of platelet inhibition: blockade of membrane receptors or neutralization of intracellular pathways. Both means of inhibition have proven benefits in the prevention and resolution of atherothrombotic events. With regard to ...