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PubMed
Drug-Induced Thrombocytopenia for the Hospitalist Physician with a Focus on Heparin-lnduced Thrombocytopenia
Hosp Pract (1995)
Acute thrombocytopenia occurs commonly in hospitalized patients. For most, the etiology of an acutely declining platelet count is obvious and includes sepsis with disseminated intravascular coagulation, large-volume crystalloid infusion, or the admin...
PubMed
PubMed
PubMed
Excorporeal Normothermic Machine Perfusion Resuscitates Pig DCD Livers with Extended Warm Ischemia
J Surg Res
BACKGROUND: The shortage in donor livers has led to increased use of allografts derived from donation after cardiac death (DCD). The compromised viability in these livers leads to inferior post-transplantation allograft function and survival compared...
PubMed
Cellular therapy and bioartificial approaches to liver replacement
Curr Opin Organ Transplant
PURPOSE OF REVIEW: The success of liver transplantation has increased over the past 20 years due to improved immunosuppressive medications, surgical technique and donor-recipient selection. To date, the number of patients waiting for a liver transpla...
PubMed
Development of normative neuropsychological performance in Thailand for the assessment of HIV-associated neurocognitive disorders
J Clin Exp Neuropsychol
International studies of HIV-associated neurocognitive disorder (HAND) are needed to determine the viral and host factors associated with cognitive impairment particularly as more than 80% of HIV+ subjects reside in resource-limited settings. Recent ...
PubMed
Human-Scale Whole-Organ Bioengineering for Liver Transplantation: A Regenerative Medicine Approach
Cell Transplant
At this time, the only definitive treatment of hepatic failure is liver transplantation. However, transplantation has been limited by the severely limited supply of human donor livers. Alternatively, a regenerative medicine approach has been recently...
PubMed
Whole-organ re-engineering: a regenerative medicine approach in digestive surgery for organ replacement
Surg Today
Recovery from end-stage organ failure presents a challenge for the medical community, considering the limitations of extracorporeal assist devices and the shortage of donors when organ replacement is needed. There is a need for new methods to promote...
PubMed
Emerging Therapies in Castrate-Resistant Prostate Cancer
Curr Urol Rep
Prostate cancer is the most common cancer in men in the United States, and despite screening and early treatment, more than 27,000 men are predicted to die of the disease this year, almost all of whom will die of castrate-resistant, metastatic cancer...
PubMed
Identification of Microdeletions in Candidate Genes for Cleft Lip and/or Palate
Birth Defects Res A Clin Mol Teratol
BACKGROUND: Genome-wide association studies are now used routinely to identify genes implicated in complex traits. The panels used for such analyses can detect single nucleotide polymorphisms and copy number variants, both of which may help to identi...
PubMed
Zscan4 restores the developmental potency of embryonic stem cells
Nat Commun
The developmental potency of mouse embryonic stem (ES) cells, which is the ability to contribute to a whole embryo is known to deteriorate during long-term cell culture. Previously we have shown that ES cells oscillate between Zscan4(-) and Zscan4(+)...
PubMed
Factors Associated With Recovery from Anorexia Nervosa
J Psychiatr Res
Previous studies of prognostic factors of anorexia nervosa (AN) course and recovery have followed clinical populations after treatment discharge. This retrospective study examined the association between prognostic factors—eating disorder features,...
PubMed
Effects of Alcohol Intoxication on Response Conflict in a Flanker Task
J Addict Res Ther
Events evoke seamlessly integrated stimulus evaluation and response preparation processing streams, guided by regulative functions that change behavior flexibly in accord with the internal goals and contextual demands. The neural basis of the effects...
PubMed
Endocrine Disruptors and the Breast: Early Life Effects and Later Life Disease
J Mammary Gland Biol Neoplasia
Breast cancer risk has both heritable and environment/lifestyle components. The heritable component is a small contribution (5–27 %), leaving the majority of risk to environment (e.g., applied chemicals, food residues, occupational hazards, pharmac...
PubMed
PubMed
EMS runs for suspected opioid overdose: Implications for surveillance and prevention
Prehosp Emerg Care
OBJECTIVE: Opioid (including prescription opiate) abuse and overdose rates in the US have surged in the past decade. The dearth and limitations of opioid abuse and overdose surveillance systems impede the development of interventions to address this ...
PubMed
The Secure Medical Research Workspace: An IT Infrastructure to Enable Secure Research on Clinical Data
Clin Transl Sci
Clinical data have tremendous value for translational research, but only if security and privacy concerns can be addressed satisfactorily. A collaboration of clinical and informatics teams, including RENCI, NC TraCS, UNC's School of Information ...
PubMed
Circumcision preference among women and uncircumcised men prior to scale-up of male circumcision for HIV prevention in Kisumu, Kenya
AIDS Care
Following the endorsement by the World Health Organization (WHO) and the Joint United Nations Programme on HIV/AIDS (UNAIDS) of male circumcision as an additional strategy to HIV prevention, initiatives to introduce safe, voluntary medical male circu...
PubMed
The Use of the Medical Dictionary for Regulatory Activities in the Identification of Mitochondrial Dysfunction in HIV-Infected Children
Case Studies Bus Ind Gov Stat
OBJECTIVE: To demonstrate the utility of a medical terminology-based method for identifying cases of possible mitochondrial dysfunction (MD) in a large cohort of youths with perinatal HIV infection and to describe the scoring algorithms. METHODS: Med...
PubMed
Multi-locus phylogenetic analysis reveals the pattern and tempo of bony fish evolution
PLoS Curr
Over half of all vertebrates are “fishes”, which exhibit enormous diversity in morphology, physiology, behavior, reproductive biology, and ecology. Investigation of fundamental areas of vertebrate biology depend critically on a robust phylogeny o...