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PubMed
Zscan4 restores the developmental potency of embryonic stem cells
Nat Commun
The developmental potency of mouse embryonic stem (ES) cells, which is the ability to contribute to a whole embryo is known to deteriorate during long-term cell culture. Previously we have shown that ES cells oscillate between Zscan4(-) and Zscan4(+)...
PubMed
Factors Associated With Recovery from Anorexia Nervosa
J Psychiatr Res
Previous studies of prognostic factors of anorexia nervosa (AN) course and recovery have followed clinical populations after treatment discharge. This retrospective study examined the association between prognostic factors—eating disorder features,...
PubMed
Effects of Alcohol Intoxication on Response Conflict in a Flanker Task
J Addict Res Ther
Events evoke seamlessly integrated stimulus evaluation and response preparation processing streams, guided by regulative functions that change behavior flexibly in accord with the internal goals and contextual demands. The neural basis of the effects...
PubMed
Endocrine Disruptors and the Breast: Early Life Effects and Later Life Disease
J Mammary Gland Biol Neoplasia
Breast cancer risk has both heritable and environment/lifestyle components. The heritable component is a small contribution (5–27 %), leaving the majority of risk to environment (e.g., applied chemicals, food residues, occupational hazards, pharmac...
PubMed
PubMed
EMS runs for suspected opioid overdose: Implications for surveillance and prevention
Prehosp Emerg Care
OBJECTIVE: Opioid (including prescription opiate) abuse and overdose rates in the US have surged in the past decade. The dearth and limitations of opioid abuse and overdose surveillance systems impede the development of interventions to address this ...
PubMed
The Secure Medical Research Workspace: An IT Infrastructure to Enable Secure Research on Clinical Data
Clin Transl Sci
Clinical data have tremendous value for translational research, but only if security and privacy concerns can be addressed satisfactorily. A collaboration of clinical and informatics teams, including RENCI, NC TraCS, UNC's School of Information ...
PubMed
Circumcision preference among women and uncircumcised men prior to scale-up of male circumcision for HIV prevention in Kisumu, Kenya
AIDS Care
Following the endorsement by the World Health Organization (WHO) and the Joint United Nations Programme on HIV/AIDS (UNAIDS) of male circumcision as an additional strategy to HIV prevention, initiatives to introduce safe, voluntary medical male circu...
PubMed
The Use of the Medical Dictionary for Regulatory Activities in the Identification of Mitochondrial Dysfunction in HIV-Infected Children
Case Studies Bus Ind Gov Stat
OBJECTIVE: To demonstrate the utility of a medical terminology-based method for identifying cases of possible mitochondrial dysfunction (MD) in a large cohort of youths with perinatal HIV infection and to describe the scoring algorithms. METHODS: Med...
PubMed
Multi-locus phylogenetic analysis reveals the pattern and tempo of bony fish evolution
PLoS Curr
Over half of all vertebrates are “fishes”, which exhibit enormous diversity in morphology, physiology, behavior, reproductive biology, and ecology. Investigation of fundamental areas of vertebrate biology depend critically on a robust phylogeny o...
PubMed
Dectin-2 Recognition of House Dust Mite Triggers Cysteinyl Leukotriene Generation by Dendritic Cells
J Immunol
House dust mites are a significant source of airborne allergen worldwide, but there is little understanding of how they so potently generate allergic inflammation. We found that extracts from the house dust mites Dermatophagoides farinae (Df) and Der...
PubMed
Collagen VI regulates satellite cell self-renewal and muscle regeneration
Nat Commun
Adult muscle stem cells, or satellite cells play essential roles in homeostasis and regeneration of skeletal muscles. Satellite cells are located within a niche that includes myofibers and extracellular matrix. The function of specific extracellular ...
PubMed
ROC Analysis in Biomarker Combination with Covariate Adjustment
Acad Radiol
RATIONAL AND OBJECTIVES: Receiver operating characteristic analysis (ROC) is often used to find the optimal combination of biomarkers. When the subject level covariates affect the magnitude and/or accuracy of the biomarkers, the combination rule shou...
PubMed
Photo-Fries-based photosensitive polymeric interlayers for patterned organic devices
Appl Phys A Mater Sci Process
This work reports on the investigation of the photosensitive polymer poly(diphenyl bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate) (PPNB), which undergoes the photo-Fries rearrangement upon illumination with UV-light, used as interfacial layers in organi...
PubMed
New approaches for the management of bipolar disorder: role of sublingual asenapine in the treatment of mania
Neuropsychiatr Dis Treat
Bipolar disorder is a prevalent disorder that tends to become progressive without treatment and with inadequate treatment. Second generation (atypical) antipsychotic drugs have increasingly been used as adjunctive treatment or monotherapy for mania, ...
PubMed
The cost of schizophrenia in Japan
Neuropsychiatr Dis Treat
INTRODUCTION: Schizophrenia is a disorder that produces considerable burdens due to its often relapsing/remitting or chronic longitudinal course. This burden is felt not only by patients themselves, but also by their families and health care systems....
PubMed
Effects of pentoxifylline, 7-nitroindazole, and imipramine on tumor necrosis factor-α and indoleamine 2,3-dioxygenase enzyme activity in the hippocampus and frontal cortex of chronic mild-stress-exposed rats
Neuropsychiatr Dis Treat
OBJECTIVES: This study aimed to investigate the role of tumor necrosis factor (TNF)-α and the neuronal nitric oxide synthase enzyme in dysregulation of indoleamine 2,3-dioxygenase (IDO) enzyme, and hence serotonin availability in chronic mild stress...
PubMed
Treatment in hospital for alcohol-dependent patients decreases attentional bias
Neuropsychiatr Dis Treat
BACKGROUND AND OBJECTIVES: Previous studies in alcohol-dependent patients have shown an attentional bias (AB) under related substance cues, which can lead to relapse. This AB can be evaluated by the alcohol Stroop test (AST). The AST is a modified St...
PubMed
A Church-Based Diet and Physical Activity Intervention for Rural, Lower Mississippi Delta African American Adults: Delta Body and Soul Effectiveness Study, 2010–2011
Prev Chronic Dis
INTRODUCTION: Obesity, diabetes, and hypertension have reached epidemic levels in the largely rural Lower Mississippi Delta (LMD) region. We assessed the effectiveness of a 6-month, church-based diet and physical activity intervention, conducted duri...
PubMed
Using Geographic Information Systems to Compare Municipal, County, and Commercial Parks Data
Prev Chronic Dis
INTRODUCTION: Parks are an integral part of a favorable built environment, and several studies have found a positive association between a favorable built environment and physical activity. Parks data are available to researchers from various sources...