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PubMed
PubMed
Transplantation of Bone Marrow-Derived Very Small Embryonic-Like Stem Cells Attenuates Left Ventricular Dysfunction and Remodeling After Myocardial Infarction
Stem Cells
Adult bone marrow (BM) contains Sca-1+/Lin−/CD45− very small embryonic-like stem cells (VSELs) that express markers of several lineages, including cardiac markers, and differentiate into cardiomyocytes in vitro. We examined whether BM-derived VSE...
PubMed
Moderate versus intensive treatment of hypertension with amlodipine/valsartan for patients uncontrolled on angiotensin receptor blocker monotherapy
J Hypertens
OBJECTIVES: Many angiotensin receptor blocker (ARB) monotherapy patients need at least two agents to control blood pressure (BP). We investigated whether initiating intensive treatment with combination amlodipine/valsartan was superior to moderate tr...
PubMed
Aquaporin 4 Molecular Mimicry and Implications for Neuromyelitis Optica
J Neuroimmunol
Neuromyelitis Optica (NMO) is associated with antibodies to aquaporin 4 (AQP4). We hypothesized that antibodies to AQP4 can be triggered by exposure to environmental proteins. We compared human AQP4 to plant and bacterial proteins to investigate the ...
PubMed
HIV among persons incarcerated in the US: a review of evolving concepts in testing, treatment and linkage to community care
Curr Opin Infect Dis
PURPOSE OF REVIEW: People who are incarcerated have a disproportionately high risk of HIV infection. They also tend to have risk factors associated with under-utilization of antiretroviral therapy such as substance abuse, mental illness, and poor acc...
PubMed
End-of-Life Discussions and Advance Care Planning for Children on Long-Term Assisted Ventilation with Life-Limiting Conditions
J Palliat Care
Families of children with life-limiting conditions who are on long-term assisted ventilation need to undertake end-of-life advance care planning (ACP) in order to align their goals and values with the inevitability of their child's condition and...
PubMed
fMRI hemodynamics accurately reflect neuronal timing in the human brain measured by MEG
Neuroimage
Neuronal activation sequence information is essential for understanding brain functions. Extracting such timing information from blood oxygenation level dependent (BOLD) fMRI is confounded by interregional neurovascular differences and poorly underst...
PubMed
Intermittent versus Continuous Androgen Deprivation in Prostate Cancer
N Engl J Med
BACKGROUND: Castration resistance occurs in most patients with metastatic hormone-sensitive prostate cancer who are receiving androgen-deprivation therapy. Replacing androgens before progression of the disease is hypothesized to prolong androgen depe...
PubMed
NOTCH2 mutations in Alagille syndrome
J Med Genet
BACKGROUND: Alagille syndrome (ALGS) is a dominant, multisystem disorder caused by mutations in the Jagged1 (JAG1) ligand in 94% of patients, and in the NOTCH2 receptor in <1%. There are only two NOTCH2 families reported to date. This study hypoth...
PubMed
Caring for Parents with Neurodegenerative Disease: A Qualitative Description
Clin Nurse Spec
PURPOSE/OBJECTIVE: To explore the positive aspects experienced by adult children in providing care to their parent who either has Parkinson’s or Alzheimer’s disease. DESIGN: A qualitative descriptive approach was used to analyze audio-taped in-de...
PubMed
Use of sodium bicarbonate to promote weight gain, maintain body temperature, normalize renal functions and prevent mortality in rodents receiving the chemotherapeutic agent cisplatin
Neurosci Lett
A simple method to reduce adverse effects of the chemotherapeutic agent cisplatin on animal health is described. Animals receiving normal saline (0.9% NaCl) s.c. prior to once weekly injections of cisplatin (3 mg/kg i.p.×3 or 4 weeks) exhibited fail...
PubMed
Labeling Stem Cells with Superparamagnetic Iron Oxide Nanoparticles: Analysis of the Labeling Efficacy by Microscopy and Magnetic Resonance Imaging
Methods Mol Biol
Stem cell therapy has emerged as a potential therapeutic option for cell death-related heart diseases. Application of non-invasive cell tracking approaches is necessary to determine tissue distribution and lifetime of stem cells following their injec...
PubMed
Role of Neuregulin-1/ErbB Signaling in Stem Cell Therapy for Spinal Cord Injury-Induced Chronic Neuropathic Pain
Stem Cells
Chronic neuropathic pain is a common and debilitating consequence of spinal cord injury (SCI). In a rat contusion injury model, we observed that chronic neuropathic pain is present on day 7 after SCI and persists for the entire 56-day observation per...
PubMed
Uncertainty During the Transition From Cancer Patient to Survivor
Cancer Nurs
This prospective study evaluated the impact that uncertainty has on quality of life as cancer patients end the active phase of their treatment. The transition from patient status to survivor may be a particularly important point in recovery because i...
PubMed
Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1
Genesis
The Notch1 receptor plays a critical role in cell fate decisions during development. Activation of Notch signaling has been implicated in several types of cancer, particularly T-cell acute lymphoblastic leukemia (T-ALL). Consequently, several transge...
PubMed
Determinants of Early Reductions in Drinking Among Older At-Risk Drinkers Participating in the Intervention Arm of a Trial to Reduce At-Risk Drinking in Primary Care
J Am Geriatr Soc
OBJECTIVES: To describe differences between at-risk drinking older adults who reduced drinking and those who did not after an initial intervention, and to determine factors associated with early reductions in drinking. DESIGN: Secondary analyses of d...
PubMed
The antiviral effect of sorafenib in hepatitis c-related hepatocellular carcinoma
Aliment Pharmacol Ther
BACKGROUND AND AIM: Sorafenib is currently the only approved systemic therapy shown to have efficacy in the treatment of advanced hepatocellular carcinoma (HCC). Recent studies suggest that hepatitis C (HCV)-related HCC patients derive more clinical ...
PubMed
Discordant cellular response to pre-surgical letrozole in bilateral synchronous ER+ breast cancers with a KRAS mutation or FGFR1 gene amplification
Mol Cancer Ther
We describe herein a patient presenting with bilateral ER+ breast tumors who was enrolled in a clinical trial exploring molecular aberrations associated with hormone-refractory tumor cell proliferation. Short-term (2-week) hormonal therapy with the a...
PubMed
How to Build an Integrated Biobank: The Washington University Translational Cardiovascular Biobank & Repository Experience
Clin Transl Sci
Translational studies that assess and extend observations made in animal models of human pathology to elucidate relevant and important determinants of human diseases require the availability of viable human tissue samples. However, there are a number...
PubMed
Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis
Hum Reprod Update
BACKGROUND: The recruitment of immune cells by chemokines and the regulation of endometrial cell apoptosis are critical aspects of endometriosis biology. Here, we review the local (paracrine) and systemic hormone (endocrine) modulation of these two s...