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PubMed
Genetic variants and the risk of gestational diabetes mellitus: a systematic review
Hum Reprod Update
BACKGROUND: Several studies have examined associations between genetic variants and the risk of gestational diabetes mellitus (GDM). However, inferences from these studies were often hindered by limited statistical power and conflicting results. We a...
PubMed
Management of pain associated with the insertion of intrauterine contraceptives
Hum Reprod Update
BACKGROUND: Most intrauterine contraception (IUC) placements do not require pain relief. However, small proportions of nulliparous (∼17%) and parous (∼11%) women experience substantial pain that needs to be proactively managed. This review critic...
PubMed
On the Use of Adjusted Cross-Sectional Estimators of HIV Incidence
J Acquir Immune Defic Syndr
OBJECTIVE: To elucidate when and how cross-sectional estimators of HIV incidence rates based on a sensitive and less-sensitive diagnostic test should be adjusted. METHODS: Evaluate the statistical properties of unadjusted and adjusted cross-sectional...
PubMed
Molecular mechanisms of pancreatic injury
Curr Opin Gastroenterol
PURPOSE OF REVIEW: The pathogenesis of acute pancreatitis (AP) is still not well understood. This articles reviews recent advances in our understanding of AP with emphasis on literature published during the last year. RECENT FINDINGS: Zymogen activat...
PubMed
Post-retrieval extinction as reconsolidation interference: methodological issues or boundary conditions?
Psychopharmacology (Berl)
Memories that are emotionally arousing generally promote the survival of species; however, the systems that modulate emotional learning can go awry, resulting in pathological conditions such as post-traumatic stress disorders, phobias, and addiction....
PubMed
Healthy Women’s Motivators and Barriers to Participation in a Breast Cancer Cohort Study: A Qualitative Study
Ann Epidemiol
BACKGROUND: This focus group study describes motivators and barriers to participation in the Mayo Mammography Health Study (MMHS), a large-scale longitudinal study examining the causal association of breast density with breast cancer, involving compl...
PubMed
Mixed Incontinence: Comparing Definitions in Non-Surgical Patients
Neurourol Urodyn
PURPOSE: We aimed to explore operational definitions of mixed urinary incontinence (MUI) for use in incontinence outcomes research for non-surgical patient populations. METHODS: A secondary analysis of women with urge incontinence or urge predominant...
PubMed
Changes in Environmental Tobacco Smoke Exposure: The Beaver Dam Experience
WMJ
OBJECTIVES: Environmental tobacco smoke (ETS) exposure has been associated with adverse health outcomes. Our goal was to determine if ETS exposure changed between 1998–2000 and 2003–2005 among participants in the population-based Epidemiology of ...
PubMed
Aerosol transmission is an important mode of influenza A virus spread
Nat Commun
Influenza A viruses are believed to spread between humans through contact, large respiratory droplets and small particle droplet nuclei (aerosols), but the relative importance of each of these modes of transmission is unclear. Volunteer studies sugge...
PubMed
A Psychoeducational Intervention (SWEEP) for Depressed Women with Diabetes
Ann Behav Med
BACKGROUND: Clinically significant depression is present in 25 % of individuals with type 2 diabetes, its risk being doubled in women. PURPOSE: To examine the effectiveness of the Study of Women's Emotions and Evaluation of a Psychoeducational (...
PubMed
Measuring and modeling the kinetics of individual DNA-DNA polymerase complexes on a nanopore
ACS Nano
The assembly of a DNA-DNA polymerase binary complex is the precursory step in genome replication, in which the enzyme binds to the 3 prime junction created when a primer binds to it’s complementary substrate. In this study, we use an active control...
PubMed
TB Research at UT-Houston – A review of cord factor: new approaches to drugs, vaccines and the pathogenesis of tuberculosis
Tuberculosis (Edinb)
Tuberculosis remains a major threat as drug resistance continues to increase. Pulmonary tuberculosis in adults is responsible for 80% of clinical cases and nearly 100% of transmission of infection. Unfortunately, since we have no animal models of adu...
PubMed
Emergency Ultrasound-assisted Examination of Skin and Soft Tissue Infections in the Pediatric Emergency Department
Acad Emerg Med
OBJECTIVES: To evaluate the test characteristics of clinical examination (CE) with the addition of bedside emergency ultrasound (CE+EUS) compared to CE alone in determining skin and soft tissue infections (SSTIs) that require drainage in pediatric pa...
PubMed
Metabolomics: the apogee of the omic triology
Nat Rev Mol Cell Biol
Metabolites, the chemical entities that are transformed during metabolism, provide a functional readout of cellular biochemistry. With emerging technologies in mass spectrometry, thousands of metabolites can now be quantitatively measured from minima...
PubMed
Vascular Endothelial Growth Factor in Eye Disease
Prog Retin Eye Res
Collectively, angiogenic ocular conditions represent the leading cause of irreversible vision loss in developed countries. In the U.S., for example, retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration are the princip...
PubMed
Interleukin-1α signaling initiates the inflammatory response to virulent Legionella pneumophila in vivo
J Immunol
Legionella pneumophila is an intracellular bacterial pathogen that is the cause of a severe pneumonia in humans called Legionnaires’ Disease. A key feature of L. pneumophila pathogenesis is the rapid influx of neutrophils into the lungs, which occu...
PubMed
Risk factors for failure of outpatient parenteral antibiotic therapy (OPAT) in infective endocarditis
J Antimicrob Chemother
OBJECTIVES: To identify risk factors for failure of outpatient antibiotic therapy (OPAT) in infective endocarditis (IE). PATIENTS AND METHODS: We identified IE cases managed at a single centre over 12 years from a prospectively maintained database. â...
PubMed
Efflux in Acinetobacter baumannii can be determined by measuring accumulation of H33342 (bis-benzamide)
J Antimicrob Chemother
OBJECTIVES: Overexpression of efflux pumps in Acinetobacter baumannii is a common mechanism of multidrug resistance in this nosocomial pathogen. Increased efflux pump expression is often assumed from MICs of antibiotics and dyes, without measurement ...
PubMed
Daptomycin use in patients with osteomyelitis: a preliminary report from the EU-CORE(SM) database
J Antimicrob Chemother
BACKGROUND: Osteomyelitis is a complex and heterogeneous group of infections that require surgical and antimicrobial interventions. Because treatment failure or intolerance is common, new treatment options are needed. Daptomycin has broad Gram-positi...
PubMed
Genetic inactivation of acrAB or inhibition of efflux induces expression of ramA
J Antimicrob Chemother
OBJECTIVES: The transcriptional activator RamA regulates production of the multidrug resistance efflux AcrAB–TolC system in several Enterobacteriaceae. This study investigated factors that lead to increased expression of ramA. METHODS: In order to ...