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PubMed
Use of sodium bicarbonate to promote weight gain, maintain body temperature, normalize renal functions and prevent mortality in rodents receiving the chemotherapeutic agent cisplatin
Neurosci Lett
A simple method to reduce adverse effects of the chemotherapeutic agent cisplatin on animal health is described. Animals receiving normal saline (0.9% NaCl) s.c. prior to once weekly injections of cisplatin (3 mg/kg i.p.×3 or 4 weeks) exhibited fail...
PubMed
Labeling Stem Cells with Superparamagnetic Iron Oxide Nanoparticles: Analysis of the Labeling Efficacy by Microscopy and Magnetic Resonance Imaging
Methods Mol Biol
Stem cell therapy has emerged as a potential therapeutic option for cell death-related heart diseases. Application of non-invasive cell tracking approaches is necessary to determine tissue distribution and lifetime of stem cells following their injec...
PubMed
Role of Neuregulin-1/ErbB Signaling in Stem Cell Therapy for Spinal Cord Injury-Induced Chronic Neuropathic Pain
Stem Cells
Chronic neuropathic pain is a common and debilitating consequence of spinal cord injury (SCI). In a rat contusion injury model, we observed that chronic neuropathic pain is present on day 7 after SCI and persists for the entire 56-day observation per...
PubMed
Uncertainty During the Transition From Cancer Patient to Survivor
Cancer Nurs
This prospective study evaluated the impact that uncertainty has on quality of life as cancer patients end the active phase of their treatment. The transition from patient status to survivor may be a particularly important point in recovery because i...
PubMed
Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1
Genesis
The Notch1 receptor plays a critical role in cell fate decisions during development. Activation of Notch signaling has been implicated in several types of cancer, particularly T-cell acute lymphoblastic leukemia (T-ALL). Consequently, several transge...
PubMed
Determinants of Early Reductions in Drinking Among Older At-Risk Drinkers Participating in the Intervention Arm of a Trial to Reduce At-Risk Drinking in Primary Care
J Am Geriatr Soc
OBJECTIVES: To describe differences between at-risk drinking older adults who reduced drinking and those who did not after an initial intervention, and to determine factors associated with early reductions in drinking. DESIGN: Secondary analyses of d...
PubMed
The antiviral effect of sorafenib in hepatitis c-related hepatocellular carcinoma
Aliment Pharmacol Ther
BACKGROUND AND AIM: Sorafenib is currently the only approved systemic therapy shown to have efficacy in the treatment of advanced hepatocellular carcinoma (HCC). Recent studies suggest that hepatitis C (HCV)-related HCC patients derive more clinical ...
PubMed
Discordant cellular response to pre-surgical letrozole in bilateral synchronous ER+ breast cancers with a KRAS mutation or FGFR1 gene amplification
Mol Cancer Ther
We describe herein a patient presenting with bilateral ER+ breast tumors who was enrolled in a clinical trial exploring molecular aberrations associated with hormone-refractory tumor cell proliferation. Short-term (2-week) hormonal therapy with the a...
PubMed
How to Build an Integrated Biobank: The Washington University Translational Cardiovascular Biobank & Repository Experience
Clin Transl Sci
Translational studies that assess and extend observations made in animal models of human pathology to elucidate relevant and important determinants of human diseases require the availability of viable human tissue samples. However, there are a number...
PubMed
Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis
Hum Reprod Update
BACKGROUND: The recruitment of immune cells by chemokines and the regulation of endometrial cell apoptosis are critical aspects of endometriosis biology. Here, we review the local (paracrine) and systemic hormone (endocrine) modulation of these two s...
PubMed
Genetic variants and the risk of gestational diabetes mellitus: a systematic review
Hum Reprod Update
BACKGROUND: Several studies have examined associations between genetic variants and the risk of gestational diabetes mellitus (GDM). However, inferences from these studies were often hindered by limited statistical power and conflicting results. We a...
PubMed
Management of pain associated with the insertion of intrauterine contraceptives
Hum Reprod Update
BACKGROUND: Most intrauterine contraception (IUC) placements do not require pain relief. However, small proportions of nulliparous (∼17%) and parous (∼11%) women experience substantial pain that needs to be proactively managed. This review critic...
PubMed
On the Use of Adjusted Cross-Sectional Estimators of HIV Incidence
J Acquir Immune Defic Syndr
OBJECTIVE: To elucidate when and how cross-sectional estimators of HIV incidence rates based on a sensitive and less-sensitive diagnostic test should be adjusted. METHODS: Evaluate the statistical properties of unadjusted and adjusted cross-sectional...
PubMed
Molecular mechanisms of pancreatic injury
Curr Opin Gastroenterol
PURPOSE OF REVIEW: The pathogenesis of acute pancreatitis (AP) is still not well understood. This articles reviews recent advances in our understanding of AP with emphasis on literature published during the last year. RECENT FINDINGS: Zymogen activat...
PubMed
Post-retrieval extinction as reconsolidation interference: methodological issues or boundary conditions?
Psychopharmacology (Berl)
Memories that are emotionally arousing generally promote the survival of species; however, the systems that modulate emotional learning can go awry, resulting in pathological conditions such as post-traumatic stress disorders, phobias, and addiction....
PubMed
Healthy Women’s Motivators and Barriers to Participation in a Breast Cancer Cohort Study: A Qualitative Study
Ann Epidemiol
BACKGROUND: This focus group study describes motivators and barriers to participation in the Mayo Mammography Health Study (MMHS), a large-scale longitudinal study examining the causal association of breast density with breast cancer, involving compl...
PubMed
Mixed Incontinence: Comparing Definitions in Non-Surgical Patients
Neurourol Urodyn
PURPOSE: We aimed to explore operational definitions of mixed urinary incontinence (MUI) for use in incontinence outcomes research for non-surgical patient populations. METHODS: A secondary analysis of women with urge incontinence or urge predominant...
PubMed
Changes in Environmental Tobacco Smoke Exposure: The Beaver Dam Experience
WMJ
OBJECTIVES: Environmental tobacco smoke (ETS) exposure has been associated with adverse health outcomes. Our goal was to determine if ETS exposure changed between 1998–2000 and 2003–2005 among participants in the population-based Epidemiology of ...
PubMed
Aerosol transmission is an important mode of influenza A virus spread
Nat Commun
Influenza A viruses are believed to spread between humans through contact, large respiratory droplets and small particle droplet nuclei (aerosols), but the relative importance of each of these modes of transmission is unclear. Volunteer studies sugge...
PubMed
A Psychoeducational Intervention (SWEEP) for Depressed Women with Diabetes
Ann Behav Med
BACKGROUND: Clinically significant depression is present in 25 % of individuals with type 2 diabetes, its risk being doubled in women. PURPOSE: To examine the effectiveness of the Study of Women's Emotions and Evaluation of a Psychoeducational (...