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PubMed
Measuring and modeling the kinetics of individual DNA-DNA polymerase complexes on a nanopore
ACS Nano
The assembly of a DNA-DNA polymerase binary complex is the precursory step in genome replication, in which the enzyme binds to the 3 prime junction created when a primer binds to it’s complementary substrate. In this study, we use an active control...
PubMed
TB Research at UT-Houston – A review of cord factor: new approaches to drugs, vaccines and the pathogenesis of tuberculosis
Tuberculosis (Edinb)
Tuberculosis remains a major threat as drug resistance continues to increase. Pulmonary tuberculosis in adults is responsible for 80% of clinical cases and nearly 100% of transmission of infection. Unfortunately, since we have no animal models of adu...
PubMed
Emergency Ultrasound-assisted Examination of Skin and Soft Tissue Infections in the Pediatric Emergency Department
Acad Emerg Med
OBJECTIVES: To evaluate the test characteristics of clinical examination (CE) with the addition of bedside emergency ultrasound (CE+EUS) compared to CE alone in determining skin and soft tissue infections (SSTIs) that require drainage in pediatric pa...
PubMed
Metabolomics: the apogee of the omic triology
Nat Rev Mol Cell Biol
Metabolites, the chemical entities that are transformed during metabolism, provide a functional readout of cellular biochemistry. With emerging technologies in mass spectrometry, thousands of metabolites can now be quantitatively measured from minima...
PubMed
Vascular Endothelial Growth Factor in Eye Disease
Prog Retin Eye Res
Collectively, angiogenic ocular conditions represent the leading cause of irreversible vision loss in developed countries. In the U.S., for example, retinopathy of prematurity, diabetic retinopathy and age-related macular degeneration are the princip...
PubMed
Interleukin-1α signaling initiates the inflammatory response to virulent Legionella pneumophila in vivo
J Immunol
Legionella pneumophila is an intracellular bacterial pathogen that is the cause of a severe pneumonia in humans called Legionnaires’ Disease. A key feature of L. pneumophila pathogenesis is the rapid influx of neutrophils into the lungs, which occu...
PubMed
Risk factors for failure of outpatient parenteral antibiotic therapy (OPAT) in infective endocarditis
J Antimicrob Chemother
OBJECTIVES: To identify risk factors for failure of outpatient antibiotic therapy (OPAT) in infective endocarditis (IE). PATIENTS AND METHODS: We identified IE cases managed at a single centre over 12 years from a prospectively maintained database. ...
PubMed
Efflux in Acinetobacter baumannii can be determined by measuring accumulation of H33342 (bis-benzamide)
J Antimicrob Chemother
OBJECTIVES: Overexpression of efflux pumps in Acinetobacter baumannii is a common mechanism of multidrug resistance in this nosocomial pathogen. Increased efflux pump expression is often assumed from MICs of antibiotics and dyes, without measurement ...
PubMed
Daptomycin use in patients with osteomyelitis: a preliminary report from the EU-CORE(SM) database
J Antimicrob Chemother
BACKGROUND: Osteomyelitis is a complex and heterogeneous group of infections that require surgical and antimicrobial interventions. Because treatment failure or intolerance is common, new treatment options are needed. Daptomycin has broad Gram-positi...
PubMed
Genetic inactivation of acrAB or inhibition of efflux induces expression of ramA
J Antimicrob Chemother
OBJECTIVES: The transcriptional activator RamA regulates production of the multidrug resistance efflux AcrAB–TolC system in several Enterobacteriaceae. This study investigated factors that lead to increased expression of ramA. METHODS: In order to ...
PubMed
PubMed
Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator mice
Mitochondrion
The mitochondrial DNA (mtDNA) polymerase γ (POLG) mutator mice provide the first experimental evidence that high levels of somatic mtDNA mutations can be functionally significant. Here we report that older homozygous, but not heterozygous, POLG mice...
PubMed
Low Bone Mass is Associated with Increased Carotid Intima Media Thickness in Men with Type 2 Diabetes Mellitus
Clin Med Insights Endocrinol Diabetes
Osteoporosis and atherosclerosis share common risk factors and the association of low bone mass with increased cardiovascular morbidity and mortality has been demonstrated in some studies. Nevertheless, most studies have been focused on women and onl...
PubMed
Recent Progress in Mouse Models for Tumor Suppressor Genes and its Implications in Human Cancer
Clin Med Insights Oncol
Gain-of-function mutations in oncogenes and loss-of-function mutations in tumor suppressor genes (TSG) lead to cancer. In most human cancers, these mutations occur in somatic tissues. However, hereditary forms of cancer exist for which individuals ar...
PubMed
Levonorgestrel-Releasing Intrauterine System and Iron Overload Syndrome
Clin Med Insights Case Rep
Severe fatigue is a common complaint among patients. This report presents a clinical case of a woman complaining of fatigue associated with diarrhea and myalgia that were first attributed to emotional stress and depression. Initially, the patient was...
PubMed
Corrigendum for “Acute Aortic Valve Rupture From Infective Endocarditis”
Clin Med Insights Case Rep
PubMed
PubMed
ACE2, angiotensin-(1-7) and Mas receptor axis in inflammation and fibrosis
Br J Pharmacol
Recent advances have improved our understanding of the renin-angiotensin system (RAS). These have included the recognition that angiotensin (Ang)-(1-7) is a biologically active product of the RAS cascade. The identification of the ACE homologue ACE2,...
PubMed
HDL and endothelial protection
Br J Pharmacol
High-density lipoproteins (HDLs) represent a family of particles characterized by the presence of apolipoprotein A-I (apoA-I) and by their ability to transport cholesterol from peripheral tissues back to the liver. In addition to this function, HDLs ...
PubMed
VIP and PACAP: neuropeptide modulators of CNS inflammation, injury, and repair
Br J Pharmacol
Inflammatory processes play both regenerative and destructive roles in multiple sclerosis, stroke, CNS trauma, amyotrophic lateral sclerosis and aging-related neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's...